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Calcium in PDB 7z3j: Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate

Enzymatic activity of Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate

All present enzymatic activity of Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate:
3.1.4.11;

Protein crystallography data

The structure of Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate, PDB code: 7z3j was solved by N.Pinotsis, T.D.Bunney, M.Katan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.29 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 72.76, 82.44, 230.11, 90, 90, 90
R / Rfree (%) 22.4 / 25.6

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate (pdb code 7z3j). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate, PDB code: 7z3j:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 7z3j

Go back to Calcium Binding Sites List in 7z3j
Calcium binding site 1 out of 2 in the Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1301

b:50.9
occ:1.00
O2 A:I3P1303 2.4 58.4 0.8
OE1 A:GLU414 2.4 53.5 1.0
OE2 A:GLU365 2.4 44.8 1.0
OD1 A:ASN336 2.4 48.1 1.0
OD1 A:ASP367 2.4 41.6 1.0
OD2 A:ASP367 2.4 47.7 1.0
O12 A:I3P1303 2.5 56.5 0.8
CG A:ASP367 2.8 45.1 1.0
CD A:GLU365 3.4 46.6 1.0
CG A:ASN336 3.4 45.0 1.0
CD A:GLU414 3.5 55.2 1.0
P1 A:I3P1303 3.7 67.6 0.8
C2 A:I3P1303 3.7 63.2 0.8
ND2 A:ASN336 3.7 41.3 1.0
O1 A:I3P1303 3.9 67.4 0.8
CG A:GLU365 4.1 45.0 1.0
CB A:GLU414 4.2 49.6 1.0
OE2 A:GLU414 4.2 48.5 1.0
O11 A:I3P1303 4.2 67.6 0.8
C1 A:I3P1303 4.2 63.3 0.8
O3 A:I3P1303 4.3 50.5 0.8
C3 A:I3P1303 4.3 62.3 0.8
OE1 A:GLU365 4.3 44.9 1.0
CB A:ASP367 4.3 45.3 1.0
C4 A:I3P1303 4.3 62.4 0.8
C6 A:I3P1303 4.4 69.6 0.8
CG A:GLU414 4.4 53.0 1.0
OH A:TYR338 4.5 40.5 1.0
CB A:ASN336 4.8 41.1 1.0
O A:HOH1524 4.8 43.7 1.0
NE2 A:HIS335 4.8 49.2 1.0
O13 A:I3P1303 4.9 63.8 0.8
C5 A:I3P1303 5.0 65.7 0.8

Calcium binding site 2 out of 2 in 7z3j

Go back to Calcium Binding Sites List in 7z3j
Calcium binding site 2 out of 2 in the Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Crystallisable Rat Phospholipase C Gamma 1 in Complex with Inositol 1,4,5-Trisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1302

b:77.8
occ:0.80
O A:HOH1623 2.3 57.8 1.0
O A:HOH1584 2.7 62.9 1.0
OE1 A:GLU351 2.7 52.8 1.0
O A:GLU351 2.8 46.5 1.0
C A:GLU351 3.6 46.8 1.0
CB A:GLU351 3.6 47.2 1.0
CA A:GLU351 3.7 48.0 1.0
CD A:GLU351 3.8 52.3 1.0
N A:ARG355 3.9 45.3 1.0
CB A:ARG355 4.0 47.6 1.0
CB A:ALA354 4.0 45.5 1.0
CD2 A:LEU110 4.1 63.0 1.0
CD1 A:LEU117 4.1 56.6 1.0
O A:HOH1619 4.1 53.2 1.0
CA A:ARG355 4.2 42.2 1.0
CG A:GLU351 4.3 50.1 1.0
NH2 A:ARG82 4.3 61.0 1.0
O A:HOH1560 4.3 60.5 1.0
CD A:ARG355 4.4 48.3 1.0
C A:ALA354 4.5 44.0 1.0
O A:HOH1636 4.5 58.8 1.0
CG A:LEU117 4.7 52.9 1.0
CA A:ALA354 4.8 50.1 1.0
CG A:ARG355 4.8 44.9 1.0
N A:ALA352 4.8 42.5 1.0
OE2 A:GLU351 4.9 63.6 1.0
CB A:LEU117 5.0 51.8 1.0

Reference:

K.I.P.Le Huray, T.D.Bunney, N.Pinotsis, A.C.Kalli, M.Katan. Characterization of the Membrane Interactions of Phospholipase C Gamma Reveals Key Features of the Active Enzyme. Sci Adv V. 8 P9688 2022.
ISSN: ESSN 2375-2548
PubMed: 35749497
DOI: 10.1126/SCIADV.ABP9688
Page generated: Fri Jul 19 06:26:36 2024

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