Calcium in PDB 7zk3: Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution

The structure of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution (pdb code 7zk3). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 6 binding sites of Calcium where determined in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution, PDB code: 7zk3:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6;

Calcium binding site 1 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1001 b:23.7 occ:1.00 OE1 A:GLU702 2.4 25.3 1.0 OE1 A:GLU705 2.4 20.7 1.0 OE2 A:GLU734 2.5 13.5 1.0 OD1 A:ASP738 3.1 14.4 1.0 OE2 A:GLU654 3.1 25.1 1.0 OE1 A:GLU654 3.2 25.1 1.0 CD A:GLU702 3.3 25.3 1.0 OD2 A:ASP738 3.4 14.4 1.0 CD A:GLU654 3.5 25.1 1.0 CD A:GLU734 3.5 13.5 1.0 CD A:GLU705 3.6 20.7 1.0 CG A:ASP738 3.7 14.4 1.0 OE2 A:GLU702 3.9 25.3 1.0 CA A:GLU702 4.0 25.3 1.0 CG A:GLU734 4.1 13.5 1.0 CB A:GLU702 4.1 25.3 1.0 CA A:CA1002 4.1 24.8 1.0 OE2 A:GLU705 4.1 20.7 1.0 OH A:TYR331 4.2 28.5 1.0 CG A:GLU702 4.3 25.3 1.0 OE1 A:GLU734 4.6 13.5 1.0 NZ A:LYS741 4.6 16.7 1.0 CE A:MET706 4.6 18.8 1.0 CG A:GLU705 4.8 20.7 1.0 CB A:GLU705 4.8 20.7 1.0 O A:GLU702 4.9 25.3 1.0 N A:GLU702 4.9 25.3 1.0 C A:GLU702 5.0 25.3 1.0 CG A:GLU654 5.0 25.1 1.0

Calcium binding site 2 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:24.8 occ:1.00 OD1 A:ASN650 2.4 21.4 1.0 OE1 A:GLU734 2.4 13.5 1.0 OE2 A:GLU654 2.5 25.1 1.0 OE2 A:GLU734 2.5 13.5 1.0 OD1 A:ASN651 2.6 19.9 1.0 CD A:GLU734 2.8 13.5 1.0 CG A:ASN650 3.4 21.4 1.0 CG A:ASN651 3.6 19.9 1.0 CD A:GLU654 3.6 25.1 1.0 OE1 A:GLU705 3.7 20.7 1.0 ND2 A:ASN650 4.1 21.4 1.0 CA A:CA1001 4.1 23.7 1.0 CD A:GLU705 4.2 20.7 1.0 N A:ASN651 4.2 19.9 1.0 CG A:GLU734 4.3 13.5 1.0 CA A:ASN651 4.3 19.9 1.0 ND2 A:ASN651 4.3 19.9 1.0 CB A:ASN650 4.4 21.4 1.0 OE1 A:GLU654 4.4 25.1 1.0 O A:GLN646 4.4 16.3 1.0 C A:ASN650 4.4 21.4 1.0 OE2 A:GLU705 4.4 20.7 1.0 CG A:GLU654 4.5 25.1 1.0 OD1 A:ASN730 4.5 12.3 1.0 CB A:ASN651 4.6 19.9 1.0 O A:ASN650 4.6 21.4 1.0

Calcium binding site 3 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1004 b:31.2 occ:1.00 O A:ASP883 2.5 21.3 1.0 OD1 A:ASP888 2.5 33.6 1.0 O A:ILE886 2.5 20.2 1.0 OD2 A:ASP883 3.0 21.3 1.0 OE1 A:GLU425 3.3 17.6 1.0 CG A:ASP888 3.6 33.6 1.0 C A:ASP883 3.6 21.3 1.0 C A:ILE886 3.7 20.2 1.0 N A:ASP888 3.9 33.6 1.0 C A:PRO887 4.1 25.9 1.0 CA A:PRO887 4.2 25.9 1.0 CG A:ASP883 4.3 21.3 1.0 OD2 A:ASP888 4.3 33.6 1.0 CD A:GLU425 4.4 17.6 1.0 CA A:ASP888 4.4 33.6 1.0 CA A:ASP883 4.5 21.3 1.0 N A:PRO887 4.5 25.9 1.0 N A:TRP884 4.6 24.5 1.0 CB A:ASP888 4.6 33.6 1.0 CA A:TRP884 4.6 24.5 1.0 NZ A:LYS428 4.6 19.0 1.0 O A:TRP884 4.7 24.5 1.0 C A:TRP884 4.8 24.5 1.0 CA A:ILE886 4.8 20.2 1.0 O A:PRO887 4.8 25.9 1.0 N A:ILE886 4.8 20.2 1.0 CB A:ASP883 5.0 21.3 1.0

Calcium binding site 4 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1001 b:22.6 occ:1.00 OE1 B:GLU702 2.4 21.6 1.0 OE1 B:GLU705 2.4 19.1 1.0 OE2 B:GLU734 2.5 13.9 1.0 OD1 B:ASP738 3.1 14.7 1.0 OE2 B:GLU654 3.1 24.9 1.0 OE1 B:GLU654 3.2 24.9 1.0 CD B:GLU702 3.3 21.6 1.0 OD2 B:ASP738 3.4 14.7 1.0 CD B:GLU654 3.5 24.9 1.0 CD B:GLU734 3.5 13.9 1.0 CD B:GLU705 3.6 19.1 1.0 CG B:ASP738 3.7 14.7 1.0 OE2 B:GLU702 3.9 21.6 1.0 CA B:GLU702 4.0 21.6 1.0 CG B:GLU734 4.1 13.9 1.0 CB B:GLU702 4.1 21.6 1.0 CA B:CA1002 4.1 25.7 1.0 OE2 B:GLU705 4.1 19.1 1.0 OH B:TYR331 4.2 28.5 1.0 CG B:GLU702 4.3 21.6 1.0 OE1 B:GLU734 4.6 13.9 1.0 NZ B:LYS741 4.6 16.9 1.0 CE B:MET706 4.6 17.4 1.0 CG B:GLU705 4.8 19.1 1.0 CB B:GLU705 4.8 19.1 1.0 O B:GLU702 4.9 21.6 1.0 N B:GLU702 4.9 21.6 1.0 C B:GLU702 5.0 21.6 1.0 CG B:GLU654 5.0 24.9 1.0

Calcium binding site 5 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:25.7 occ:1.00 OD1 B:ASN650 2.4 21.9 1.0 OE1 B:GLU734 2.4 13.9 1.0 OE2 B:GLU654 2.5 24.9 1.0 OE2 B:GLU734 2.5 13.9 1.0 OD1 B:ASN651 2.6 20.2 1.0 CD B:GLU734 2.8 13.9 1.0 CG B:ASN650 3.4 21.9 1.0 CG B:ASN651 3.6 20.2 1.0 CD B:GLU654 3.6 24.9 1.0 OE1 B:GLU705 3.7 19.1 1.0 CA B:CA1001 4.1 22.6 1.0 ND2 B:ASN650 4.1 21.9 1.0 CD B:GLU705 4.2 19.1 1.0 N B:ASN651 4.3 20.2 1.0 CG B:GLU734 4.3 13.9 1.0 CA B:ASN651 4.3 20.2 1.0 ND2 B:ASN651 4.3 20.2 1.0 CB B:ASN650 4.4 21.9 1.0 OE1 B:GLU654 4.4 24.9 1.0 O B:GLN646 4.4 16.5 1.0 C B:ASN650 4.4 21.9 1.0 OE2 B:GLU705 4.5 19.1 1.0 CG B:GLU654 4.5 24.9 1.0 OD1 B:ASN730 4.5 12.2 1.0 CB B:ASN651 4.6 20.2 1.0 O B:ASN650 4.6 21.9 1.0

Calcium binding site 6 out of 6 in the Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of 1PBC- and Calcium-Bound MTMEM16A(Ac) Chloride Channel at 2.85 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1004 b:31.5 occ:1.00 O B:ASP883 2.5 20.5 1.0 OD1 B:ASP888 2.5 35.0 1.0 O B:ILE886 2.5 20.5 1.0 OD2 B:ASP883 3.0 20.5 1.0 OE1 B:GLU425 3.3 15.5 1.0 CG B:ASP888 3.6 35.0 1.0 C B:ASP883 3.6 20.5 1.0 C B:ILE886 3.7 20.5 1.0 N B:ASP888 3.9 35.0 1.0 C B:PRO887 4.1 26.5 1.0 CA B:PRO887 4.2 26.5 1.0 CG B:ASP883 4.3 20.5 1.0 OD2 B:ASP888 4.3 35.0 1.0 CD B:GLU425 4.4 15.5 1.0 CA B:ASP888 4.4 35.0 1.0 CA B:ASP883 4.5 20.5 1.0 N B:PRO887 4.5 26.5 1.0 N B:TRP884 4.6 24.1 1.0 CB B:ASP888 4.6 35.0 1.0 CA B:TRP884 4.6 24.1 1.0 NZ B:LYS428 4.6 18.7 1.0 O B:TRP884 4.7 24.1 1.0 C B:TRP884 4.8 24.1 1.0 CA B:ILE886 4.8 20.5 1.0 O B:PRO887 4.8 26.5 1.0 N B:ILE886 4.8 20.5 1.0 CB B:ASP883 5.0 20.5 1.0

A.K.M.Lam, S.Rutz, R.Dutzler. Inhibition Mechanism of the Chloride Channel TMEM16A By the Pore Blocker 1PBC. Nat Commun V. 13 2798 2022.
ISSN: ESSN 2041-1723
PubMed: 35589730
DOI: 10.1038/S41467-022-30479-1