Calcium in PDB 8c47: Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin

The structure of Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin, PDB code: 8c47 was solved by K.Kogan, T.Kotila, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.16 / 2.20
Space group	I 41
Cell size a, b, c (Å), α, β, γ (°)	171.297, 171.297, 43.694, 90, 90, 90
R / Rfree (%)	19.3 / 22.6

The binding sites of Calcium atom in the Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin (pdb code 8c47). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin, PDB code: 8c47:

Calcium binding site 1 out of 1 in the Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Leishmania Atp-Actin Monomer in Complex with Leishmania Profilin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca403 b:45.0 occ:1.00 O A:HOH549 2.3 43.8 1.0 O1G A:ATP402 2.3 46.4 1.0 O A:HOH510 2.4 40.9 1.0 O A:HOH523 2.4 41.2 1.0 O A:HOH551 2.4 50.0 1.0 O1B A:ATP402 2.5 46.8 1.0 O A:HOH546 2.5 44.3 1.0 PG A:ATP402 3.3 44.5 1.0 PB A:ATP402 3.5 44.3 1.0 O3B A:ATP402 3.6 44.8 1.0 O3G A:ATP402 3.7 39.8 1.0 CA A:GLY13 4.1 51.2 1.0 O A:HOH517 4.1 39.8 1.0 O A:HOH528 4.2 52.4 1.0 O A:HOH505 4.2 59.2 1.0 O3A A:ATP402 4.3 39.7 1.0 OE1 A:GLN137 4.3 58.5 1.0 O1A A:ATP402 4.4 42.4 1.0 NZ A:LYS18 4.4 50.3 1.0 OD2 A:ASP154 4.5 59.0 1.0 CD A:GLN137 4.5 50.1 1.0 OD2 A:ASP11 4.5 43.9 1.0 OD1 A:ASP11 4.7 45.1 1.0 O2G A:ATP402 4.7 39.3 1.0 O2B A:ATP402 4.9 44.5 1.0 NE2 A:GLN137 4.9 40.5 1.0 PA A:ATP402 4.9 47.1 1.0 N A:GLY13 4.9 52.2 1.0

A.Vizcaino-Castillo, T.Kotila, K.Kogan, R.Yanase, J.Como, L.Antenucci, A.Michelot, J.D.Sunter, P.Lappalainen. Leishmania Profilin Interacts with Actin Through An Unusual Structural Mechanism to Control Cytoskeletal Dynamics in Parasites. J.Biol.Chem. V. 300 05740 2024.
ISSN: ESSN 1083-351X
PubMed: 38340794
DOI: 10.1016/J.JBC.2024.105740