Calcium in PDB 8e4m: The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2

The binding sites of Calcium atom in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2 (pdb code 8e4m). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2, PDB code: 8e4m:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1203 b:102.4 occ:1.00 HE21 A:GLN785 2.0 143.8 1.0 OE1 A:GLN785 2.5 139.8 1.0 NE2 A:GLN785 2.6 142.0 1.0 CD A:GLN785 2.8 142.1 1.0 HE22 A:GLN785 3.3 143.8 1.0 OD2 A:ASP802 3.5 149.7 1.0 OD1 A:ASN799 3.6 153.4 1.0 OE2 A:GLU1004 4.1 103.4 1.0 CG A:ASN799 4.2 154.5 1.0 HD21 A:ASN799 4.2 155.3 1.0 HA A:ASN799 4.2 154.5 1.0 OE2 A:GLU782 4.2 150.8 1.0 CG A:GLN785 4.3 144.2 1.0 CG A:ASP802 4.3 149.6 1.0 OE1 A:GLU1004 4.4 98.8 1.0 ND2 A:ASN799 4.4 155.4 1.0 CD A:GLU1004 4.4 100.5 1.0 HH22 A:ARG842 4.5 127.7 1.0 HB3 A:GLN785 4.6 144.3 1.0 HG2 A:GLN785 4.6 143.9 1.0 OD1 A:ASP802 4.7 149.7 1.0 HG3 A:GLN785 4.9 144.0 1.0 CB A:GLN785 4.9 145.4 1.0 CA A:ASN799 5.0 154.2 1.0 HB2 A:GLN785 5.0 144.2 1.0

Calcium binding site 2 out of 4 in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1203 b:102.4 occ:1.00 HE21 B:GLN785 2.0 143.8 1.0 OE1 B:GLN785 2.5 139.8 1.0 NE2 B:GLN785 2.6 142.0 1.0 CD B:GLN785 2.8 142.1 1.0 HE22 B:GLN785 3.3 143.8 1.0 OD2 B:ASP802 3.5 149.7 1.0 OD1 B:ASN799 3.6 153.4 1.0 OE2 B:GLU1004 4.1 103.4 1.0 CG B:ASN799 4.2 154.5 1.0 HD21 B:ASN799 4.2 155.3 1.0 HA B:ASN799 4.2 154.5 1.0 OE2 B:GLU782 4.2 150.8 1.0 CG B:GLN785 4.3 144.2 1.0 CG B:ASP802 4.3 149.6 1.0 OE1 B:GLU1004 4.4 98.8 1.0 ND2 B:ASN799 4.4 155.4 1.0 CD B:GLU1004 4.4 100.5 1.0 HH22 B:ARG842 4.5 127.7 1.0 HB3 B:GLN785 4.6 144.3 1.0 HG2 B:GLN785 4.6 143.9 1.0 OD1 B:ASP802 4.7 149.7 1.0 HG3 B:GLN785 4.9 144.0 1.0 CB B:GLN785 4.9 145.4 1.0 CA B:ASN799 5.0 154.2 1.0 HB2 B:GLN785 5.0 144.2 1.0

Calcium binding site 3 out of 4 in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1203 b:102.4 occ:1.00 HE21 C:GLN785 2.0 143.8 1.0 OE1 C:GLN785 2.5 139.8 1.0 NE2 C:GLN785 2.6 142.0 1.0 CD C:GLN785 2.8 142.1 1.0 HE22 C:GLN785 3.3 143.8 1.0 OD2 C:ASP802 3.5 149.7 1.0 OD1 C:ASN799 3.6 153.4 1.0 OE2 C:GLU1004 4.1 103.4 1.0 CG C:ASN799 4.2 154.5 1.0 HD21 C:ASN799 4.2 155.3 1.0 HA C:ASN799 4.2 154.5 1.0 OE2 C:GLU782 4.2 150.8 1.0 CG C:GLN785 4.3 144.2 1.0 CG C:ASP802 4.3 149.6 1.0 OE1 C:GLU1004 4.4 98.8 1.0 ND2 C:ASN799 4.4 155.4 1.0 CD C:GLU1004 4.4 100.5 1.0 HH22 C:ARG842 4.5 127.7 1.0 HB3 C:GLN785 4.6 144.3 1.0 HG2 C:GLN785 4.6 143.9 1.0 OD1 C:ASP802 4.7 149.7 1.0 HG3 C:GLN785 4.9 144.0 1.0 CB C:GLN785 4.9 145.4 1.0 CA C:ASN799 5.0 154.2 1.0 HB2 C:GLN785 5.0 144.2 1.0

Calcium binding site 4 out of 4 in the The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of The Intermediate C2-State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3 and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1203 b:102.4 occ:1.00 HE21 D:GLN785 2.0 143.8 1.0 OE1 D:GLN785 2.5 139.8 1.0 NE2 D:GLN785 2.6 142.0 1.0 CD D:GLN785 2.8 142.1 1.0 HE22 D:GLN785 3.3 143.8 1.0 OD2 D:ASP802 3.5 149.7 1.0 OD1 D:ASN799 3.6 153.4 1.0 OE2 D:GLU1004 4.1 103.4 1.0 CG D:ASN799 4.2 154.5 1.0 HD21 D:ASN799 4.2 155.3 1.0 HA D:ASN799 4.2 154.5 1.0 OE2 D:GLU782 4.2 150.8 1.0 CG D:GLN785 4.3 144.2 1.0 CG D:ASP802 4.3 149.6 1.0 OE1 D:GLU1004 4.4 98.8 1.0 ND2 D:ASN799 4.4 155.4 1.0 CD D:GLU1004 4.4 100.5 1.0 HH22 D:ARG842 4.5 127.7 1.0 HB3 D:GLN785 4.6 144.3 1.0 HG2 D:GLN785 4.6 143.9 1.0 OD1 D:ASP802 4.7 149.7 1.0 HG3 D:GLN785 4.9 144.0 1.0 CB D:GLN785 4.9 145.4 1.0 CA D:ASN799 5.0 154.2 1.0 HB2 D:GLN785 5.0 144.2 1.0

Y.Yin, F.Zhang, S.Feng, K.J.Butay, M.J.Borgnia, W.Im, S.Y.Lee. Activation Mechanism of the Mouse Cold-Sensing TRPM8 Channel By Cooling Agonist and Pip 2. Science V. 378 D1268 2022.
ISSN: ESSN 1095-9203
PubMed: 36227998
DOI: 10.1126/SCIENCE.ADD1268