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Calcium in PDB 8fjm: Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group

Enzymatic activity of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group

All present enzymatic activity of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group:
2.1.1.360;

Protein crystallography data

The structure of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group, PDB code: 8fjm was solved by V.S.Frisbie, H.Hashimoto, E.W.Debler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.81 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 41.934, 81.625, 170.115, 90, 90, 90
R / Rfree (%) 16 / 18.6

Other elements in 8fjm:

The structure of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group (pdb code 8fjm). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group, PDB code: 8fjm:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 8fjm

Go back to Calcium Binding Sites List in 8fjm
Calcium binding site 1 out of 2 in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca303

b:15.7
occ:1.00
 O A:ARG236 2.3 16.0 1.0
OE2 A:GLU207 2.4 18.6 1.0
O A:HOH473 2.4 13.7 1.0
CD A:GLU207 3.2 18.2 1.0
HB3 A:ARG236 3.2 21.6 1.0
C A:ARG236 3.4 16.2 1.0
OE1 A:GLU207 3.6 17.8 1.0
CB A:ARG236 4.0 18.0 1.0
HA A:VAL237 4.1 19.6 1.0
O A:HOH441 4.1 17.4 1.0
HA A:ARG236 4.1 22.2 1.0
CA A:ARG236 4.1 18.4 1.0
HB2 A:ARG236 4.3 21.6 1.0
HG3 A:GLU207 4.3 19.5 1.0
CG A:GLU207 4.3 16.2 1.0
N A:VAL237 4.5 16.6 1.0
O A:GLU203 4.5 16.7 1.0
HG2 A:GLU207 4.5 19.5 1.0
HH12 A:ARG233 4.6 23.6 1.0
CA A:VAL237 4.7 16.3 1.0
OE1 A:GLU203 4.7 18.1 1.0
HD3 A:PRO238 4.8 19.7 1.0
C A:VAL237 4.9 15.7 1.0
HD2 A:ARG236 4.9 26.9 1.0
HG3 A:PRO238 4.9 23.5 1.0
HB3 A:GLU203 4.9 24.9 1.0

Calcium binding site 2 out of 2 in 8fjm

Go back to Calcium Binding Sites List in 8fjm
Calcium binding site 2 out of 2 in the Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase in Complex with Adohcy - P212121 Space Group within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca304

b:14.2
occ:1.00
 O B:ARG236 2.3 15.4 1.0
O B:HOH467 2.4 17.6 1.0
O B:ACT302 2.4 17.8 1.0
O B:HOH533 2.4 14.8 1.0
OE2 B:GLU207 2.4 17.6 1.0
C B:ACT302 3.0 19.2 1.0
OXT B:ACT302 3.0 25.1 1.0
CD B:GLU207 3.2 17.9 1.0
HB3 B:ARG236 3.3 23.9 1.0
C B:ARG236 3.5 18.5 1.0
OE1 B:GLU207 3.6 19.1 1.0
O B:HOH420 4.0 17.1 1.0
HA B:VAL237 4.1 19.0 1.0
CB B:ARG236 4.1 19.9 1.0
CA B:ARG236 4.2 18.6 1.0
HA B:ARG236 4.2 22.4 1.0
HG3 B:GLU207 4.4 24.6 1.0
CG B:GLU207 4.4 20.4 1.0
HB2 B:ARG236 4.4 23.9 1.0
N B:VAL237 4.5 19.5 1.0
CH3 B:ACT302 4.5 17.0 1.0
O B:GLU203 4.5 23.0 1.0
HH12 B:ARG233 4.6 23.5 1.0
HG2 B:GLU207 4.6 24.6 1.0
CA B:VAL237 4.6 15.8 1.0
HD3 B:PRO238 4.7 21.5 1.0
OE1 B:GLU203 4.8 22.9 1.0
H2 B:ACT302 4.8 20.5 1.0
C B:VAL237 4.9 15.9 1.0
HB3 B:GLU203 4.9 26.5 1.0
HG3 B:PRO238 4.9 21.8 1.0
H1 B:ACT302 4.9 20.5 1.0
HD2 B:ARG236 5.0 25.7 1.0

Reference:

V.S.Frisbie, H.Hashimoto, Y.Xie, J.Baeza, T.Nguyen, Z.Yuan, B.A.Garcia, E.W.Debler. Structure and Mechanism of the Atypical Trypanosoma Brucei DOT1A Histone H3K76 Methyltransferase To Be Published.
Page generated: Fri Jul 19 08:55:58 2024

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