Calcium in PDB 8fob: Cryo-Em Structure of Human TRPV6 in the Open State

The binding sites of Calcium atom in the Cryo-Em Structure of Human TRPV6 in the Open State (pdb code 8fob). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Cryo-Em Structure of Human TRPV6 in the Open State, PDB code: 8fob:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Cryo-Em Structure of Human TRPV6 in the Open State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Human TRPV6 in the Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca812 b:45.4 occ:1.00 CA A:CA813 2.1 45.7 1.0 OD1 A:ASP542 2.4 24.9 1.0 OD1 C:ASP542 2.4 27.1 1.0 OD1 B:ASP542 2.5 24.9 1.0 OD1 D:ASP542 2.5 24.4 1.0 OD2 D:ASP542 2.5 24.4 1.0 OD2 A:ASP542 2.5 24.9 1.0 OD2 C:ASP542 2.5 27.1 1.0 OD2 B:ASP542 2.5 24.9 1.0 CG A:ASP542 2.8 24.9 1.0 CG C:ASP542 2.8 27.1 1.0 CG D:ASP542 2.8 24.4 1.0 CG B:ASP542 2.8 24.9 1.0 CB A:ASP542 4.2 24.9 1.0 CB D:ASP542 4.3 24.4 1.0 CB C:ASP542 4.3 27.1 1.0 CB B:ASP542 4.3 24.9 1.0 CA D:ASP542 4.9 24.4 1.0 CA A:ASP542 4.9 24.9 1.0 CA C:ASP542 4.9 27.1 1.0 CA B:ASP542 4.9 24.9 1.0

Calcium binding site 2 out of 2 in the Cryo-Em Structure of Human TRPV6 in the Open State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Human TRPV6 in the Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca813 b:45.7 occ:1.00 CA A:CA812 2.1 45.4 1.0 OD1 A:ASP542 2.6 24.9 1.0 OD1 C:ASP542 2.6 27.1 1.0 OD1 B:ASP542 2.6 24.9 1.0 OD1 D:ASP542 2.6 24.4 1.0 CG A:ASP542 3.6 24.9 1.0 CG D:ASP542 3.6 24.4 1.0 CG B:ASP542 3.6 24.9 1.0 CG C:ASP542 3.6 27.1 1.0 O B:HOH912 3.7 2.8 1.0 O C:HOH912 3.7 0.0 1.0 O A:HOH912 3.7 2.1 1.0 O D:HOH912 3.7 24.1 1.0 OD2 D:ASP542 4.0 24.4 1.0 OD2 A:ASP542 4.0 24.9 1.0 OD2 B:ASP542 4.0 24.9 1.0 OD2 C:ASP542 4.0 27.1 1.0 CB A:ASP542 4.8 24.9 1.0 CB D:ASP542 4.8 24.4 1.0 CB B:ASP542 4.9 24.9 1.0 CB C:ASP542 4.9 27.1 1.0 CA D:ASP542 4.9 24.4 1.0 CA A:ASP542 4.9 24.9 1.0 CA B:ASP542 4.9 24.9 1.0 CA C:ASP542 4.9 27.1 1.0 N D:ASP542 5.0 24.4 1.0

A.Neuberger, Y.A.Trofimov, M.V.Yelshanskaya, K.D.Nadezhdin, N.A.Krylov, R.G.Efremov, A.I.Sobolevsky. Structural Mechanism of Human Oncochannel TRPV6 Inhibition By the Natural Phytoestrogen Genistein. Nat Commun V. 14 2659 2023.
ISSN: ESSN 2041-1723
PubMed: 37160865
DOI: 10.1038/S41467-023-38352-5