Calcium in PDB 8fq1: GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150)

The binding sites of Calcium atom in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150) (pdb code 8fq1). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150), PDB code: 8fq1:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca901 b:109.6 occ:1.00 O A:HOH1001 2.4 37.1 1.0 O C:HOH901 2.4 37.2 1.0 O A:HOH1019 2.4 52.5 1.0 O D:HOH927 2.4 54.4 1.0 O D:HOH930 2.4 42.1 1.0 O B:HOH1028 2.4 42.8 1.0 O B:HOH1004 2.4 44.3 1.0 O D:HOH903 2.4 44.2 1.0 O A:HOH1027 4.0 58.9 1.0 O A:GLN586 4.2 49.6 1.0 O C:GLN586 4.2 45.8 1.0 O B:GLN586 4.4 40.4 1.0 O D:GLN586 4.4 42.3 1.0 O B:GLN587 4.7 56.4 1.0 O D:GLN587 4.7 55.8 1.0 C A:GLN586 4.8 41.8 1.0 C C:GLN586 4.8 37.7 1.0

Calcium binding site 2 out of 2 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L-Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca901 b:65.2 occ:1.00 O B:HOH1024 2.4 44.4 1.0 O D:HOH924 2.4 42.6 1.0 O C:HOH920 2.4 36.5 1.0 O A:HOH1021 2.4 38.1 1.0 O B:HOH1032 2.4 33.3 1.0 O C:HOH924 2.4 41.0 1.0 O A:HOH1025 2.4 41.0 1.0 O D:HOH902 4.0 25.0 1.0 O B:HOH1003 4.0 26.6 1.0 O B:HOH1022 4.2 47.9 1.0 O D:HOH922 4.2 44.4 1.0 O D:ALA618 4.9 35.8 1.0 O B:ALA618 4.9 36.5 1.0 CB C:ALA621 5.0 26.2 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3