Calcium in PDB 8fqb: GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10)

The structure of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10) also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Calcium atom in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10) (pdb code 8fqb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10), PDB code: 8fqb:

Calcium binding site 1 out of 1 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 10MM CACL2, 140MM Nmdg, 330UM Ctz, and 100MM L- Glutamate (Open-CA10) within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca901 b:66.7 occ:1.00 O C:HOH1016 2.4 39.3 1.0 O A:HOH918 2.4 38.4 1.0 O D:HOH923 2.4 32.4 1.0 O B:HOH924 2.4 35.5 1.0 O B:HOH931 2.8 30.6 1.0 O D:HOH907 4.1 36.4 1.0 O B:HOH907 4.2 34.5 1.0 CB C:ALA621 4.8 17.7 1.0 O C:THR617 4.9 12.8 1.0 O D:THR617 5.0 33.1 1.0 O D:ALA618 5.0 35.4 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3