Calcium in PDB 8hlp: Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo)

The binding sites of Calcium atom in the Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo) (pdb code 8hlp). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo), PDB code: 8hlp:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2312 b:61.0 occ:1.00 OE2 A:GLU363 2.4 69.6 1.0 O12 A:3PE2311 3.3 77.3 1.0 CD A:GLU363 3.6 69.6 1.0 OE2 A:GLU1135 4.0 69.3 1.0 O A:GLY705 4.0 68.0 1.0 C11 A:3PE2311 4.1 77.3 1.0 O A:GLY1463 4.1 70.6 1.0 CG A:GLU363 4.4 69.6 1.0 O A:PHE1134 4.4 71.9 1.0 OE1 A:GLU363 4.5 69.6 1.0 O A:THR1462 4.7 68.6 1.0 CB A:PHE1134 4.7 71.9 1.0 P A:3PE2311 4.7 77.3 1.0 O A:THR1133 4.8 69.4 1.0 CD A:GLU1135 4.9 69.3 1.0 O A:THR704 4.9 68.2 1.0 O13 A:3PE2311 4.9 77.3 1.0 CG A:GLU1135 4.9 69.3 1.0 C12 A:3PE2311 5.0 77.3 1.0

Calcium binding site 2 out of 2 in the Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Human High-Voltage Activated L-Type Calcium Channel CAV1.2 (Apo) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2313 b:68.0 occ:1.00 OE1 A:GLU363 2.3 69.6 1.0 OE2 A:GLU1135 2.3 69.3 1.0 OE1 A:GLU1135 2.3 69.3 1.0 CD A:GLU1135 2.7 69.3 1.0 O A:GLU706 3.1 68.2 1.0 CD A:GLU363 3.4 69.6 1.0 OE1 A:GLU1464 3.5 71.2 1.0 OE2 A:GLU363 3.9 69.6 1.0 OE2 A:GLU706 4.0 68.2 1.0 CG A:GLU1135 4.2 69.3 1.0 C A:GLU706 4.2 68.2 1.0 CD A:GLU1464 4.2 71.2 1.0 O A:GLY1463 4.4 70.6 1.0 OE2 A:GLU1464 4.5 71.2 1.0 OD1 A:ASP707 4.5 67.8 1.0 CD A:GLU706 4.5 68.2 1.0 N A:ALA1465 4.5 70.4 1.0 CG A:GLU363 4.7 69.6 1.0 N A:GLY364 4.7 71.9 1.0 CA A:GLU706 4.7 68.2 1.0 CA A:GLU1464 4.7 71.2 1.0 CA A:GLU363 4.8 69.6 1.0 CB A:GLU363 4.9 69.6 1.0 CG A:GLU706 4.9 68.2 1.0 O A:PHE1134 5.0 71.9 1.0 CB A:GLU1135 5.0 69.3 1.0

Y.Wei, Z.Yu, L.Wang, X.Li, N.Li, Q.Bai, Y.Wang, R.Li, Y.Meng, H.Xu, X.Wang, Y.Dong, Z.Huang, X.C.Zhang, Y.Zhao. Structural Bases of Inhibitory Mechanism of Ca V 1.2 Channel Inhibitors. Nat Commun V. 15 2772 2024.
ISSN: ESSN 2041-1723
PubMed: 38555290
DOI: 10.1038/S41467-024-47116-8