Calcium in PDB 8s0l: Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07

All present enzymatic activity of Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07:
3.4.21.122;

The structure of Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07, PDB code: 8s0l was solved by S.Duquerroy, I.Fernandez, F.Rey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.82 / 1.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	182.665, 53.808, 65.477, 90, 100.74, 90
R / Rfree (%)	17.7 / 21.5

The binding sites of Calcium atom in the Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07 (pdb code 8s0l). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07, PDB code: 8s0l:

Calcium binding site 1 out of 1 in the Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the TMPRSS2 Zymogen in Complex with the Nanobody A07 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca602 b:70.0 occ:1.00 O A:VAL136 2.3 91.0 1.0 O A:ASN131 2.3 93.6 1.0 OE2 A:GLU145 2.4 75.0 1.0 OD2 A:ASP144 2.5 73.6 1.0 OD1 A:ASP134 2.5 91.1 1.0 ND1 A:HIS138 2.9 92.7 1.0 CD A:GLU145 3.4 76.8 1.0 C A:ASN131 3.4 94.5 1.0 C A:VAL136 3.5 90.2 1.0 CG A:ASP134 3.5 93.7 1.0 CG A:ASP144 3.5 77.5 1.0 CE1 A:HIS138 3.7 92.2 1.0 CG A:GLU145 3.9 71.2 1.0 CG A:HIS138 4.0 93.3 1.0 N A:ASP134 4.0 91.1 1.0 N A:HIS138 4.0 92.5 1.0 OD2 A:ASP134 4.1 92.6 1.0 N A:VAL136 4.1 89.2 1.0 CB A:ASP144 4.1 73.6 1.0 CA A:ASN131 4.2 94.4 1.0 CA A:VAL136 4.3 92.8 1.0 CB A:HIS138 4.3 93.9 1.0 N A:CYS133 4.3 93.0 1.0 CB A:ASN131 4.4 95.2 1.0 N A:TRP132 4.4 95.7 1.0 OE1 A:GLU145 4.4 69.9 1.0 OD1 A:ASP144 4.4 74.4 1.0 N A:SER137 4.5 94.5 1.0 CB A:ASP134 4.5 91.1 1.0 CA A:TRP132 4.6 94.6 1.0 CA A:SER137 4.6 91.2 1.0 CA A:ASP134 4.6 90.5 1.0 CB A:VAL136 4.6 89.7 1.0 O A:ASP144 4.6 64.7 1.0 N A:GLY135 4.7 89.3 1.0 C A:TRP132 4.7 93.7 1.0 C A:ASP134 4.8 89.6 1.0 C A:SER137 4.8 91.8 1.0 CA A:HIS138 4.8 93.4 1.0 C A:ASP144 4.9 73.5 1.0 NE2 A:HIS138 4.9 92.5 1.0

I.Fernandez, N.Saunders, S.Duquerroy, W.H.Boland, A.Arbabian, E.Baquero, P.Lafaye, A.Haouz, J.Buchrieser, O.Schwartz, F.Rey. Structural Insights Into TMPRSS2 Maturation and HKU1 Binding To Be Published.