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Calcium in PDB 8se2: Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride

Enzymatic activity of Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride

All present enzymatic activity of Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride:
2.7.11.13;

Protein crystallography data

The structure of Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride, PDB code: 8se2 was solved by A.T.Q.Cong, T.L.Witter, E.S.Bruinsma, S.Jayaraman, J.R.Hawse, M.P.Goetz, M.J.Schellenberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.70 / 2.95
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 162.745, 157.927, 85.144, 90, 112.23, 90
R / Rfree (%) 19.4 / 25.2

Other elements in 8se2:

The structure of Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride also contains other interesting chemical elements:

Zinc (Zn) 8 atoms
Manganese (Mn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride (pdb code 8se2). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride, PDB code: 8se2:

Calcium binding site 1 out of 1 in 8se2

Go back to Calcium Binding Sites List in 8se2
Calcium binding site 1 out of 1 in the Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Full-Length Human Protein Kinase C Beta 1 (Pkcbi) in the Active and Inactive Conformation Soaked in Manganese Chloride within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca708

b:119.0
occ:1.00
 O B:TRP247 2.4 102.3 1.0
OD1 B:ASP187 2.4 138.8 1.0
OD1 B:ASP193 2.4 102.3 1.0
OD1 B:ASP246 2.4 93.0 1.0
OD2 B:ASP187 2.4 135.1 1.0
CG B:ASP187 2.7 130.2 1.0
CG B:ASP246 3.2 103.4 1.0
OD2 B:ASP246 3.2 111.9 1.0
C B:TRP247 3.5 111.9 1.0
CG B:ASP193 3.6 100.2 1.0
CB B:ASP248 4.1 142.9 1.0
OD1 B:ASP248 4.1 145.9 1.0
CB B:ASP187 4.2 115.4 1.0
CA B:ASP248 4.2 140.1 1.0
N B:ASP248 4.2 129.0 1.0
CB B:ASP193 4.3 101.2 1.0
N B:TRP247 4.3 121.2 1.0
N B:ASP193 4.4 87.9 1.0
CA B:TRP247 4.5 118.1 1.0
C B:ASP246 4.5 112.5 1.0
OD2 B:ASP193 4.5 105.1 1.0
CB B:ASP246 4.6 102.1 1.0
CG B:ASP248 4.6 145.2 1.0
O B:ASP246 4.8 110.2 1.0

Reference:

A.T.Q.Cong, T.L.Witter, E.S.Bruinsma, S.S.Bhattacharya, S.Jayaraman, M.B.Dugan, J.Paluncic, M.J.Kuffel, J.Farmakes, J.Alvey, X.Wu, A.P.Fields, A.Pandey, J.R.Hawse, M.P.Goetz, M.J.Schellenberg. Molecular Basis of Allosteric Regulation and Pharmaceutical Targeting of Protein Kinase C B To Be Published.
Page generated: Tue Aug 26 19:36:09 2025

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