Calcium in PDB 8sik: KCNQ1 with Voltage Sensor in the Up Conformation

The binding sites of Calcium atom in the KCNQ1 with Voltage Sensor in the Up Conformation (pdb code 8sik). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the KCNQ1 with Voltage Sensor in the Up Conformation, PDB code: 8sik:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca201 b:53.3 occ:1.00 OE2 B:GLU32 2.4 53.0 1.0 O B:THR27 2.5 48.1 1.0 OD1 B:ASP21 3.1 56.1 1.0 CD B:GLU32 3.3 50.0 1.0 CB B:ASP25 3.5 54.8 1.0 OE1 B:GLU32 3.6 54.3 1.0 C B:THR27 3.6 50.8 1.0 OD2 B:ASP25 3.6 58.3 1.0 OG1 B:THR27 3.8 50.9 1.0 CG B:ASP25 3.8 57.3 1.0 CG2 B:THR29 4.1 45.1 1.0 CB B:ASP23 4.2 61.5 1.0 N B:THR27 4.2 46.1 1.0 OD2 B:ASP23 4.2 68.4 1.0 CG B:ASP21 4.2 56.6 1.0 CA B:THR27 4.3 44.8 1.0 CB B:THR27 4.5 46.7 1.0 N B:ILE28 4.6 45.7 1.0 OD2 B:ASP21 4.6 62.1 1.0 CG B:ASP23 4.7 66.1 1.0 CG B:GLU32 4.7 48.6 1.0 CA B:ASP25 4.7 56.2 1.0 OD1 B:ASP25 4.7 55.5 1.0 CA B:ILE28 4.8 39.0 1.0 N B:ASP25 4.9 58.1 1.0 N B:GLY26 5.0 51.0 1.0 N B:THR29 5.0 42.8 1.0

Calcium binding site 2 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca202 b:40.0 occ:0.46 OE2 B:GLU105 4.0 44.1 1.0 CD2 B:HIS108 4.1 36.2 1.0 CG B:HIS108 4.2 37.4 1.0 OE1 B:GLU105 4.2 45.1 1.0 NE2 B:HIS108 4.2 37.0 1.0 ND1 B:HIS108 4.3 39.6 1.0 CE1 B:HIS108 4.4 38.2 1.0 CD B:GLU105 4.4 43.6 1.0 CB B:HIS108 4.7 31.5 1.0 CG D:PRO67 5.0 60.5 1.0

Calcium binding site 3 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca201 b:60.0 occ:1.00 OD2 D:ASP23 4.9 75.4 1.0

Calcium binding site 4 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range:

Calcium binding site 5 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca201 b:37.8 occ:0.45 ND2 F:ASN61 2.4 45.2 1.0 OG1 F:THR63 2.7 54.2 1.0 CG F:ASN61 3.2 47.1 1.0 OD1 F:ASN61 3.3 47.0 1.0 OE1 F:GLU68 3.4 49.0 1.0 CG2 F:THR27 3.4 53.0 1.0 N F:ASP65 3.7 52.7 1.0 CB F:ASP65 3.8 48.8 1.0 C F:THR63 4.0 46.5 1.0 O F:THR63 4.0 53.8 1.0 CB F:THR63 4.0 47.2 1.0 C F:ILE64 4.1 45.8 1.0 N F:ILE64 4.2 40.1 1.0 CA F:ASP65 4.2 49.2 1.0 CA F:THR63 4.4 40.3 1.0 CA F:ILE64 4.5 43.8 1.0 CD F:GLU68 4.6 46.2 1.0 CB F:ASN61 4.6 43.5 1.0 CB F:THR27 4.7 52.1 1.0 N F:THR63 4.7 48.7 1.0 O F:ILE64 4.7 46.1 1.0

Calcium binding site 6 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca201 b:32.9 occ:0.51 NE2 H:HIS108 3.8 44.0 1.0 ND2 B:ASN61 3.8 45.2 1.0 CE1 H:HIS108 3.9 46.9 1.0 CB B:ASP65 3.9 46.6 1.0 CB H:ASN112 4.5 35.0 1.0 ND2 H:ASN112 4.5 41.4 1.0 CG2 B:THR27 4.8 47.8 1.0

Calcium binding site 7 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca202 b:58.1 occ:1.00 CE H:LYS31 3.2 60.8 1.0 NZ H:LYS31 3.6 60.0 1.0 CD H:LYS31 4.5 57.5 1.0 OG1 H:THR29 4.6 41.0 1.0 CG H:LYS31 4.8 57.6 1.0 CB H:LYS31 4.9 55.9 1.0

Calcium binding site 8 out of 8 in the KCNQ1 with Voltage Sensor in the Up Conformation


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of KCNQ1 with Voltage Sensor in the Up Conformation within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca203 b:38.2 occ:0.49 OE1 H:GLU68 2.2 50.7 1.0 OD1 H:ASN61 2.2 49.3 1.0 ND2 H:ASN61 2.8 48.3 1.0 CG H:ASN61 2.9 49.8 1.0 OD1 H:ASP57 3.1 43.9 1.0 O H:THR63 3.2 55.6 1.0 CD H:GLU68 3.3 47.9 1.0 OE2 H:GLU68 3.8 50.1 1.0 C H:THR63 3.8 47.8 1.0 OG1 H:THR63 3.8 55.0 1.0 CB H:ASP59 4.0 44.9 1.0 N H:ASP65 4.2 55.3 1.0 CG H:ASP57 4.3 48.9 1.0 CB H:ASN61 4.3 46.1 1.0 N H:THR63 4.4 51.1 1.0 CG H:GLU68 4.4 44.5 1.0 N H:ILE64 4.4 41.7 1.0 CA H:ILE64 4.5 45.6 1.0 CA H:THR63 4.6 42.4 1.0 N H:ASN61 4.6 43.8 1.0 CB H:ASP65 4.7 50.9 1.0 N H:ASP59 4.7 57.1 1.0 C H:ILE64 4.7 46.9 1.0 CB H:THR63 4.8 49.3 1.0 N H:GLY60 4.9 47.4 1.0 CA H:ASP59 4.9 48.2 1.0 CB H:ASP57 4.9 44.6 1.0 CA H:ASN61 5.0 42.8 1.0

V.S.Mandala, R.Mackinnon. The Membrane Electric Field Regulates the Pip 2 -Binding Site to Gate the KCNQ1 Channel. Proc.Natl.Acad.Sci.Usa V. 120 85120 2023.
ISSN: ESSN 1091-6490
PubMed: 37192161
DOI: 10.1073/PNAS.2301985120