Calcium in PDB 8tpo: NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+

The binding sites of Calcium atom in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+ (pdb code 8tpo). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+, PDB code: 8tpo:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca801 b:77.1 occ:1.00 OE2 B:GLU535 2.3 71.3 1.0 OD1 B:ASP503 2.3 72.2 1.0 OE1 B:GLU506 2.3 70.2 1.0 OE2 B:GLU452 2.4 85.5 1.0 OD1 B:ASP539 3.2 70.5 1.0 CD B:GLU452 3.2 85.5 1.0 OD2 B:ASP539 3.2 70.5 1.0 OE1 B:GLU452 3.3 85.5 1.0 CD B:GLU506 3.4 70.2 1.0 CD B:GLU535 3.5 71.3 1.0 CG B:ASP503 3.5 72.2 1.0 CG B:ASP539 3.6 70.5 1.0 OE2 B:GLU506 4.0 70.2 1.0 CA B:CA802 4.0 86.0 1.0 CG B:GLU535 4.2 71.3 1.0 CA B:ASP503 4.3 72.2 1.0 OD2 B:ASP503 4.4 72.2 1.0 CB B:ASP503 4.4 72.2 1.0 OE1 B:GLU535 4.4 71.3 1.0 CB B:GLU506 4.5 70.2 1.0 CG B:GLU506 4.5 70.2 1.0 CG B:GLU452 4.6 85.5 1.0 OH B:TYR188 4.6 66.0 1.0 NZ B:LYS542 4.8 73.2 1.0 CE B:MET507 4.9 66.0 1.0

Calcium binding site 2 out of 4 in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca802 b:86.0 occ:1.00 OE1 B:GLU535 2.3 71.3 1.0 OD1 B:ASN448 2.3 85.1 1.0 OE1 B:GLU452 2.6 85.5 1.0 OE2 B:GLU535 2.6 71.3 1.0 CD B:GLU535 2.8 71.3 1.0 CG B:ASN448 3.5 85.1 1.0 CD B:GLU452 3.6 85.5 1.0 OE1 B:GLU506 3.8 70.2 1.0 CA B:CA801 4.0 77.1 1.0 OE2 B:GLU452 4.1 85.5 1.0 ND2 B:ASN448 4.1 85.1 1.0 CG B:GLU535 4.3 71.3 1.0 N B:PHE449 4.6 87.4 1.0 CD B:GLU506 4.6 70.2 1.0 CA B:PHE449 4.6 87.4 1.0 CB B:ASN448 4.6 85.1 1.0 C B:ASN448 4.6 85.1 1.0 O B:ASN448 4.7 85.1 1.0 CB B:GLU452 4.7 85.5 1.0 CG B:GLU452 4.7 85.5 1.0 OE2 B:GLU506 5.0 70.2 1.0

Calcium binding site 3 out of 4 in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca902 b:77.1 occ:1.00 OE2 A:GLU535 2.3 71.3 1.0 OD1 A:ASP503 2.3 72.2 1.0 OE1 A:GLU506 2.3 70.2 1.0 OE2 A:GLU452 2.4 85.5 1.0 OD1 A:ASP539 3.2 70.5 1.0 CD A:GLU452 3.2 85.5 1.0 OD2 A:ASP539 3.2 70.5 1.0 OE1 A:GLU452 3.3 85.5 1.0 CD A:GLU506 3.4 70.2 1.0 CD A:GLU535 3.5 71.3 1.0 CG A:ASP503 3.5 72.2 1.0 CG A:ASP539 3.6 70.5 1.0 OE2 A:GLU506 4.0 70.2 1.0 CA A:CA903 4.0 86.0 1.0 CG A:GLU535 4.2 71.3 1.0 CA A:ASP503 4.3 72.2 1.0 OD2 A:ASP503 4.4 72.2 1.0 CB A:ASP503 4.4 72.2 1.0 OE1 A:GLU535 4.4 71.3 1.0 CB A:GLU506 4.5 70.2 1.0 CG A:GLU506 4.5 70.2 1.0 CG A:GLU452 4.6 85.5 1.0 OH A:TYR188 4.6 66.0 1.0 NZ A:LYS542 4.8 73.2 1.0 CE A:MET507 4.9 66.0 1.0

Calcium binding site 4 out of 4 in the NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of NHTMEM16 R432A Mutant in Lipid Nanodiscs with MSP1E3 Scaffold Protein in the Presence of CA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca903 b:86.0 occ:1.00 OE1 A:GLU535 2.3 71.3 1.0 OD1 A:ASN448 2.3 85.1 1.0 OE1 A:GLU452 2.6 85.5 1.0 OE2 A:GLU535 2.6 71.3 1.0 CD A:GLU535 2.8 71.3 1.0 CG A:ASN448 3.5 85.1 1.0 CD A:GLU452 3.6 85.5 1.0 OE1 A:GLU506 3.8 70.2 1.0 CA A:CA902 4.0 77.1 1.0 OE2 A:GLU452 4.1 85.5 1.0 ND2 A:ASN448 4.1 85.1 1.0 CG A:GLU535 4.3 71.3 1.0 N A:PHE449 4.6 87.4 1.0 CD A:GLU506 4.6 70.2 1.0 CA A:PHE449 4.6 87.4 1.0 CB A:ASN448 4.6 85.1 1.0 C A:ASN448 4.6 85.1 1.0 O A:ASN448 4.7 85.1 1.0 CB A:GLU452 4.7 85.5 1.0 CG A:GLU452 4.7 85.5 1.0 OE2 A:GLU506 5.0 70.2 1.0

Z.Feng, O.E.Alvarenga, A.Accardi. Structural Basis of Closed Groove Scrambling By A TMEM16 Protein. Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
PubMed: 38684930
DOI: 10.1038/S41594-024-01284-9