Calcium in PDB 8wa8: Human Transketolase in Complex with Phosphite

The structure of Human Transketolase in Complex with Phosphite, PDB code: 8wa8 was solved by Z.Liu, K.Tittmann, S.Dai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.57 / 1.48
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	114.5, 86.4, 73.4, 90, 125.5, 90
R / Rfree (%)	13.3 / 17.8

The binding sites of Calcium atom in the Human Transketolase in Complex with Phosphite (pdb code 8wa8). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Human Transketolase in Complex with Phosphite, PDB code: 8wa8:

Calcium binding site 1 out of 1 in the Human Transketolase in Complex with Phosphite


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Transketolase in Complex with Phosphite within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca701 b:24.0 occ:1.00 O A:LEU187 2.1 23.0 1.0 OD1 A:ASP155 2.1 21.3 1.0 O1A A:TPP702 2.1 21.9 1.0 O3B A:TPP702 2.2 21.7 1.0 OD1 A:ASN185 2.2 21.9 1.0 O A:HOH905 2.3 22.2 1.0 CG A:ASN185 3.2 21.4 1.0 PB A:TPP702 3.3 22.4 1.0 PA A:TPP702 3.3 23.4 1.0 CG A:ASP155 3.3 21.6 1.0 C A:LEU187 3.3 23.3 1.0 O3A A:TPP702 3.4 23.1 1.0 ND2 A:ASN185 3.5 22.5 1.0 O2B A:TPP702 3.7 23.1 1.0 OD2 A:ASP155 3.9 24.3 1.0 N A:ASP155 4.0 20.0 1.0 N A:LEU187 4.0 21.4 1.0 N A:GLY156 4.1 22.3 1.0 O7 A:TPP702 4.1 25.2 1.0 N A:GLY188 4.3 23.3 1.0 CA A:LEU187 4.3 22.5 1.0 NZ A:LYS244 4.3 20.7 1.0 CA A:GLY188 4.4 24.4 1.0 O A:ASP183 4.4 23.1 1.0 O2A A:TPP702 4.5 23.9 1.0 CB A:ASP155 4.5 22.6 1.0 CB A:ASN185 4.5 23.1 1.0 N A:ASN185 4.6 20.6 1.0 O1B A:TPP702 4.6 23.0 1.0 CA A:ASP155 4.6 20.8 1.0 C A:ASN185 4.7 20.0 1.0 N A:ARG186 4.7 21.7 1.0 CD A:LYS244 4.8 22.1 1.0 CA A:ASN185 4.8 20.4 1.0 C A:ASP155 4.9 19.6 1.0 C A:ARG186 4.9 23.2 1.0 C A:GLY154 5.0 21.1 1.0 CE A:LYS244 5.0 21.3 1.0

Z.Liu, C.Xiao, S.Lin, K.Tittmann, S.Dai. Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis Acs Catalysis V. 14 355 2024.
ISSN: ESSN 2155-5435
DOI: 10.1021/ACSCATAL.3C04543