Calcium in PDB 8we8: Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution

The structure of Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution (pdb code 8we8). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution, PDB code: 8we8:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2301 b:49.8 occ:1.00 OE2 A:GLU363 2.4 39.6 1.0 OE1 A:GLU706 2.4 38.9 1.0 OE1 A:GLU363 2.8 49.2 1.0 OE2 A:GLU1135 2.9 42.0 1.0 CD A:GLU363 3.0 44.8 1.0 OE1 A:GLU1135 3.1 36.3 1.0 CD A:GLU1135 3.4 37.0 1.0 CD A:GLU706 3.6 39.0 1.0 O A:GLY1463 3.7 46.6 1.0 O A:GLU1464 4.0 47.5 1.0 O A:PHE1134 4.1 37.1 1.0 OE2 A:GLU706 4.2 42.0 1.0 CG A:GLU363 4.5 36.9 1.0 CA A:GLU706 4.5 31.6 1.0 CA A:GLU1464 4.7 36.6 1.0 OE2 A:GLU1464 4.7 45.0 1.0 CB A:GLU706 4.7 28.5 1.0 CG A:GLU706 4.8 32.6 1.0 C A:GLU1464 4.8 40.4 1.0 C A:GLY1463 4.8 34.1 1.0 N A:ASP707 4.8 35.5 1.0 CG A:GLU1135 4.9 28.2 1.0 O A:GLY705 5.0 34.9 1.0

Calcium binding site 2 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine, Amlodipine and Pinaverium at 2.9 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:53.4 occ:1.00 OG D:SER263 2.3 31.0 1.0 OG D:SER261 2.4 21.9 1.0 OD2 A:ASP151 2.4 38.2 1.0 CB D:SER261 3.3 17.0 1.0 CG2 D:THR331 3.4 48.5 1.0 CB D:THR331 3.4 45.8 1.0 CG A:ASP151 3.5 30.2 1.0 CB D:SER263 3.5 18.6 1.0 OD1 A:ASP151 3.8 39.3 1.0 OD2 D:ASP259 4.0 26.0 1.0 OG1 D:THR331 4.2 42.0 1.0 N D:SER263 4.2 14.2 1.0 CA D:SER263 4.4 10.6 1.0 N D:THR331 4.5 44.9 1.0 OD1 D:ASP363 4.5 31.6 1.0 CA D:THR331 4.5 46.2 1.0 OD2 D:ASP363 4.6 28.9 1.0 OD1 D:ASP259 4.7 36.1 1.0 CA D:SER261 4.7 12.3 1.0 CB A:ASP151 4.8 22.4 1.0 CG D:ASP259 4.8 29.6 1.0 C D:SER261 4.9 26.9 1.0 N D:GLY262 4.9 30.9 1.0

S.Gao, X.Yao, J.Chen, G.Huang, X.Fan, L.Xue, Z.Li, T.Wu, Y.Zheng, J.Huang, X.Jin, Y.Wang, Z.Wang, Y.Yu, L.Liu, X.Pan, C.Song, N.Yan. Structural Basis For Human Ca V 1.2 Inhibition By Multiple Drugs and the Neurotoxin Calciseptine. Cell V. 186 5363 2023.
ISSN: ISSN 1097-4172
PubMed: 37972591
DOI: 10.1016/J.CELL.2023.10.007