Calcium in PDB 8wpg: Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent

The structure of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent (pdb code 8wpg). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent, PDB code: 8wpg:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca905 b:98.6 occ:1.00 O B:LEU87 2.5 71.7 1.0 O B:SER84 2.8 72.0 1.0 O B:LEU88 2.8 76.4 1.0 O B:ILE81 2.9 62.6 1.0 O B:ASN82 3.4 55.5 1.0 C B:LEU88 3.6 74.1 1.0 C B:LEU87 3.7 68.8 1.0 O B:LEU91 3.8 81.4 1.0 C B:ASN82 3.9 55.3 1.0 C B:SER84 3.9 71.6 1.0 CA B:ASN82 3.9 53.4 1.0 C B:ILE81 4.0 58.0 1.0 CB B:LEU88 4.3 73.8 1.0 CA B:LEU88 4.3 72.6 1.0 N B:PRO89 4.3 84.6 1.0 N B:ASN82 4.4 48.6 1.0 N B:LEU88 4.4 70.8 1.0 CA B:PRO85 4.4 70.8 1.0 CA B:PRO89 4.5 81.6 1.0 N B:PRO85 4.6 74.7 1.0 N B:SER84 4.7 69.3 1.0 CA B:LEU87 4.8 68.7 1.0 N B:LEU87 4.9 74.9 1.0 CG2 B:ILE81 4.9 50.3 1.0 OD1 B:ASN82 4.9 55.3 1.0 CA B:SER84 4.9 72.4 1.0 C B:PRO85 4.9 74.5 1.0 N B:SER83 5.0 62.8 1.0

Calcium binding site 2 out of 4 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca906 b:123.3 occ:1.00 O B:GLY557 2.4 105.8 1.0 C B:GLY557 3.5 100.6 1.0 OD1 A:ASP234 3.7 67.3 1.0 O A:GLU231 4.1 56.7 1.0 CA B:GLY557 4.2 98.6 1.0 OE2 B:GLU558 4.4 91.5 1.0 N B:GLU558 4.5 88.5 1.0 O A:GLU232 4.6 57.8 1.0 CA B:GLU558 4.7 84.5 1.0 CG A:ASP234 4.8 67.3 1.0

Calcium binding site 3 out of 4 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca907 b:98.2 occ:1.00 O A:GLY557 2.6 96.8 1.0 OD1 B:ASP234 2.8 64.7 1.0 CG B:ASP234 3.4 62.1 1.0 OD2 B:ASP234 3.5 59.3 1.0 C A:GLY557 3.6 95.5 1.0 O B:GLU231 4.1 62.6 1.0 CA A:GLY557 4.1 94.3 1.0 N A:GLU558 4.6 90.5 1.0 CB B:ASP234 4.7 55.0 1.0 O B:GLU232 4.8 58.1 1.0 CA B:ASP234 4.9 57.0 1.0 OE2 A:GLU558 4.9 92.2 1.0 N B:ASP234 4.9 51.8 1.0 CA A:GLU558 4.9 89.0 1.0

Calcium binding site 4 out of 4 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca904 b:96.5 occ:1.00 O A:SER84 2.3 72.6 1.0 O A:ILE81 2.9 59.9 1.0 N A:LEU88 2.9 72.0 1.0 O A:LEU88 3.3 82.0 1.0 C A:LEU88 3.4 76.7 1.0 CA A:LEU88 3.5 75.0 1.0 C A:SER84 3.6 71.6 1.0 CB A:LEU88 3.8 74.8 1.0 OG A:SER84 3.9 66.5 1.0 C A:LEU87 3.9 75.0 1.0 N A:LEU87 3.9 73.4 1.0 CB A:LEU87 4.0 68.9 1.0 C A:ILE81 4.0 56.7 1.0 CA A:PRO85 4.1 76.5 1.0 CA A:LEU87 4.1 70.3 1.0 N A:PRO89 4.2 83.3 1.0 N A:PRO85 4.3 78.1 1.0 C A:PRO85 4.3 77.3 1.0 O A:ASN82 4.3 58.7 1.0 CG2 A:ILE81 4.5 50.6 1.0 CA A:ASN82 4.6 53.1 1.0 CA A:SER84 4.6 71.2 1.0 C A:ASN82 4.6 58.8 1.0 N A:ALA86 4.6 81.0 1.0 O A:PRO85 4.7 75.6 1.0 N A:ASN82 4.8 54.1 1.0 CA A:PRO89 4.8 83.1 1.0 N A:SER84 4.8 68.0 1.0 CB A:SER84 4.9 69.0 1.0 O A:LEU91 5.0 73.3 1.0 CA A:ILE81 5.0 54.7 1.0 CG A:LEU88 5.0 70.8 1.0

S.Ling, X.Meng, Y.Zhang, Z.Xia, Y.Zhou, F.Yang, P.Shi, C.Shi, C.Tian. Structural Insights Into Asymmetric Activation of the Calcium-Sensing Receptor-G Q Complex. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37919470
DOI: 10.1038/S41422-023-00892-2