Calcium in PDB 8x91: P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic

The binding sites of Calcium atom in the P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic (pdb code 8x91). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic, PDB code: 8x91:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1202 b:30.0 occ:1.00 OG B:SER263 2.5 82.2 1.0 OD2 A:ASP125 2.5 89.8 1.0 OG B:SER261 2.8 82.7 1.0 OG1 B:THR331 2.9 84.8 1.0 CB B:SER261 3.4 82.7 1.0 CB B:SER263 3.6 82.2 1.0 CG A:ASP125 3.6 89.8 1.0 CB B:THR331 3.9 84.8 1.0 OD1 A:ASP125 4.0 89.8 1.0 N B:SER263 4.3 82.2 1.0 OD1 B:ASP363 4.5 83.2 1.0 CA B:SER263 4.6 82.2 1.0 OD2 B:ASP259 4.6 71.2 1.0 N B:THR331 4.7 84.8 1.0 OD2 B:ASP363 4.7 83.2 1.0 O B:GLY364 4.8 85.6 1.0 CA B:SER261 4.8 82.7 1.0 CG2 B:THR331 4.9 84.8 1.0 CB A:ASP125 4.9 89.8 1.0 CA B:THR331 5.0 84.8 1.0

Calcium binding site 2 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2603 b:96.4 occ:1.00 OE2 A:GLU318 2.0 73.6 1.0 CD A:GLU318 2.8 73.6 1.0 OE1 A:GLU667 3.0 75.1 1.0 OE1 A:GLU1459 3.1 72.8 1.0 OE1 A:GLU318 3.2 73.6 1.0 O A:GLY1754 3.8 72.0 1.0 OE2 A:GLU1755 3.8 73.4 1.0 OE2 A:GLU1459 3.9 72.8 1.0 CD A:GLU1459 3.9 72.8 1.0 CD A:GLU667 3.9 75.1 1.0 CG A:GLU318 4.1 73.6 1.0 OE2 A:GLU667 4.2 75.1 1.0 CD A:GLU1755 4.4 73.4 1.0 O A:MET317 4.7 73.8 1.0 CA A:GLU318 4.7 73.6 1.0 CA A:CA2614 4.8 117.7 1.0 CA A:GLU1755 4.9 73.4 1.0 CB A:GLU318 4.9 73.6 1.0 N A:ASP668 4.9 79.3 1.0 C A:GLY1754 5.0 72.0 1.0 OE1 A:GLU1755 5.0 73.4 1.0

Calcium binding site 3 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of P/Q Type Calcium Channel in Complex with Omega-Conotoxin Mviic within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2614 b:117.7 occ:1.00 OE2 A:GLU1459 3.9 72.8 1.0 C11 A:CLR2601 4.2 20.0 1.0 OE2 A:GLU318 4.3 73.6 1.0 C12 A:CLR2601 4.7 20.0 1.0 O A:GLY1754 4.8 72.0 1.0 CA A:CA2603 4.8 96.4 1.0 O A:THR1457 4.8 65.4 1.0 O A:THR665 4.8 68.7 1.0 OE1 A:GLU667 4.9 75.1 1.0 O A:GLY666 4.9 75.0 1.0 O A:THR1753 5.0 67.4 1.0

Z.Li, Y.Cong, T.Wu, T.Wang, X.Lou, X.Yang, N.Yan. Structural Basis For Different Omega-Agatoxin Iva Sensitivities of the P-Type and Q-Type Ca V 2.1 Channels. Cell Res. 2024.
ISSN: ISSN 1001-0602
PubMed: 38443561
DOI: 10.1038/S41422-024-00940-5