Calcium in PDB 8x93: P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva

The binding sites of Calcium atom in the P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva (pdb code 8x93). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva, PDB code: 8x93:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:62.5 occ:1.00 OG B:SER263 2.5 59.1 1.0 OG B:SER261 2.6 56.7 1.0 OD2 A:ASP125 2.6 66.6 1.0 OG1 B:THR331 2.8 64.2 1.0 CB B:SER263 3.5 59.1 1.0 CB B:SER261 3.5 56.7 1.0 CG A:ASP125 3.6 66.6 1.0 OD1 A:ASP125 3.8 66.6 1.0 CB B:THR331 4.0 64.2 1.0 N B:SER263 4.2 59.1 1.0 N B:THR331 4.4 64.2 1.0 CA B:SER263 4.5 59.1 1.0 OD2 B:ASP259 4.5 53.7 1.0 CA B:THR331 4.8 64.2 1.0 CA B:SER261 4.8 56.7 1.0 N B:GLY262 4.9 58.5 1.0 CB A:ASP125 5.0 66.6 1.0 C B:SER261 5.0 56.7 1.0 OD1 B:ASP363 5.0 59.6 1.0

Calcium binding site 2 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2603 b:96.4 occ:1.00 CA A:CA2613 3.9 58.0 1.0 OE1 A:GLU1459 4.0 47.7 1.0 OE1 A:GLU318 4.1 51.9 1.0 O A:THR1457 4.5 41.9 1.0 C12 A:CLR2601 4.5 20.0 1.0 OE1 A:GLU667 4.6 51.8 1.0 C11 A:CLR2601 4.6 20.0 1.0 O A:GLY666 4.7 49.8 1.0 O A:THR1753 4.8 46.8 1.0

Calcium binding site 3 out of 3 in the P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of P/Q Type Calcium Channel in Complex with Omega-Agatoxin Iva within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2613 b:58.0 occ:1.00 OE2 A:GLU1459 2.4 47.7 1.0 OE1 A:GLU1459 2.5 47.7 1.0 OE2 A:GLU318 2.5 51.9 1.0 CD A:GLU1459 2.8 47.7 1.0 OE1 A:GLU318 2.8 51.9 1.0 CD A:GLU318 2.9 51.9 1.0 OE1 A:GLU667 3.2 51.8 1.0 CA A:CA2603 3.9 96.4 1.0 CD A:GLU667 4.1 51.8 1.0 O A:GLY1754 4.2 48.1 1.0 CG A:GLU318 4.2 51.9 1.0 O A:MET317 4.3 50.3 1.0 OE2 A:GLU667 4.3 51.8 1.0 CG A:GLU1459 4.3 47.7 1.0 CA A:GLU318 4.7 51.9 1.0 C A:GLY1754 4.7 48.1 1.0 CB A:GLU318 4.8 51.9 1.0 OE2 A:GLU1755 4.9 50.8 1.0 CA A:GLU1755 4.9 50.8 1.0 O A:GLY666 5.0 49.8 1.0

Z.Li, Y.Cong, T.Wu, T.Wang, X.Lou, X.Yang, N.Yan. Structural Basis For Different Omega-Agatoxin Iva Sensitivities of the P-Type and Q-Type Ca V 2.1 Channels. Cell Res. 2024.
ISSN: ISSN 1001-0602
PubMed: 38443561
DOI: 10.1038/S41422-024-00940-5