Calcium in PDB 9asq: Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1

All present enzymatic activity of Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1:
3.1.26.3;

The structure of Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1 also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Calcium atom in the Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1 (pdb code 9asq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1, PDB code: 9asq:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1403 b:30.0 occ:1.00 OE2 A:GLU1147 2.4 141.8 1.0 OP1 E:U31 2.5 159.9 1.0 OE2 A:GLU1222 3.3 141.2 1.0 OD1 A:ASP1219 3.3 148.2 1.0 OE1 A:GLU1222 3.4 141.2 1.0 CD A:GLU1147 3.5 141.8 1.0 CD A:GLU1222 3.7 141.2 1.0 P E:U31 3.8 159.9 1.0 CG A:GLU1147 4.0 141.8 1.0 O E:HOH202 4.0 30.0 1.0 C5' E:U31 4.1 159.9 1.0 O5' E:U31 4.2 159.9 1.0 CG A:ASP1219 4.4 148.2 1.0 OE1 A:GLU1147 4.5 141.8 1.0 OP2 E:U31 4.8 159.9 1.0 O3' E:G30 4.8 153.4 1.0 OD2 A:ASP1219 5.0 148.2 1.0

Calcium binding site 2 out of 2 in the Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Drosha, DGCR8 and SRSF3 in Complex with Pri-Let-7F1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1404 b:30.0 occ:1.00 OE2 A:GLU969 2.6 30.0 1.0 OE1 A:GLU1045 3.1 124.2 1.0 OD1 A:ASN1042 3.2 127.5 1.0 CD A:GLU969 3.6 30.0 1.0 OE2 A:GLU1045 3.7 124.2 1.0 CD A:GLU1045 3.8 124.2 1.0 CG A:GLU969 4.0 30.0 1.0 CG A:ASN1042 4.2 127.5 1.0 OE1 A:GLU969 4.6 30.0 1.0 OD1 A:ASN1006 4.7 129.7 1.0 ND2 A:ASN1042 4.9 127.5 1.0 OD2 A:ASP973 4.9 123.9 1.0

A.Garg, L.Joshua-Tor. RNAI_PROTEIN_F1_SR To Be Published.