Calcium in PDB 9b92: Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius

The binding sites of Calcium atom in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius (pdb code 9b92). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius, PDB code: 9b92:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2001 b:120.8 occ:1.00 OE2 A:GLU828 2.1 112.5 1.0 OD1 A:ASN865 2.1 113.6 1.0 OE1 A:GLN831 2.2 113.6 1.0 CD A:GLU828 2.8 112.5 1.0 OE1 A:GLU828 2.8 112.5 1.0 CD A:GLN831 3.2 113.6 1.0 CG A:ASN865 3.4 113.6 1.0 OD2 A:ASP868 3.5 107.3 1.0 NE2 A:GLN831 3.6 113.6 1.0 OE2 A:GLU1068 4.2 104.5 1.0 ND2 A:ASN865 4.2 113.6 1.0 CG A:GLU828 4.3 112.5 1.0 CA A:ASN865 4.3 113.6 1.0 CB A:ASN865 4.4 113.6 1.0 CG A:ASP868 4.5 107.3 1.0 CG A:GLN831 4.6 113.6 1.0 N A:ASN865 4.8 113.6 1.0 CB A:ASP868 4.8 107.3 1.0 CB A:GLN831 4.8 113.6 1.0 CE1 A:TYR859 4.8 118.2 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca2001 b:120.8 occ:1.00 OE2 B:GLU828 2.1 112.5 1.0 OD1 B:ASN865 2.1 113.6 1.0 OE1 B:GLN831 2.2 113.6 1.0 CD B:GLU828 2.8 112.5 1.0 OE1 B:GLU828 2.8 112.5 1.0 CD B:GLN831 3.2 113.6 1.0 CG B:ASN865 3.4 113.6 1.0 OD2 B:ASP868 3.5 107.3 1.0 NE2 B:GLN831 3.6 113.6 1.0 OE2 B:GLU1068 4.2 104.5 1.0 ND2 B:ASN865 4.2 113.6 1.0 CG B:GLU828 4.3 112.5 1.0 CA B:ASN865 4.3 113.6 1.0 CB B:ASN865 4.4 113.6 1.0 CG B:ASP868 4.5 107.3 1.0 CG B:GLN831 4.6 113.6 1.0 N B:ASN865 4.8 113.6 1.0 CB B:ASP868 4.8 107.3 1.0 CB B:GLN831 4.8 113.6 1.0 CE1 B:TYR859 4.8 118.2 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca2001 b:120.8 occ:1.00 OE2 C:GLU828 2.1 112.5 1.0 OD1 C:ASN865 2.1 113.6 1.0 OE1 C:GLN831 2.2 113.6 1.0 CD C:GLU828 2.8 112.5 1.0 OE1 C:GLU828 2.8 112.5 1.0 CD C:GLN831 3.2 113.6 1.0 CG C:ASN865 3.4 113.6 1.0 OD2 C:ASP868 3.5 107.3 1.0 NE2 C:GLN831 3.6 113.6 1.0 OE2 C:GLU1068 4.2 104.5 1.0 ND2 C:ASN865 4.2 113.6 1.0 CG C:GLU828 4.3 112.5 1.0 CA C:ASN865 4.3 113.6 1.0 CB C:ASN865 4.4 113.6 1.0 CG C:ASP868 4.5 107.3 1.0 CG C:GLN831 4.6 113.6 1.0 N C:ASN865 4.8 113.6 1.0 CB C:ASP868 4.8 107.3 1.0 CB C:GLN831 4.8 113.6 1.0 CE1 C:TYR859 4.8 118.2 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the Human TRPM4 in Complex with Calcium at 18 Degrees Celsius within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca2001 b:120.8 occ:1.00 OE2 D:GLU828 2.1 112.5 1.0 OD1 D:ASN865 2.1 113.6 1.0 OE1 D:GLN831 2.2 113.6 1.0 CD D:GLU828 2.8 112.5 1.0 OE1 D:GLU828 2.8 112.5 1.0 CD D:GLN831 3.2 113.6 1.0 CG D:ASN865 3.4 113.6 1.0 OD2 D:ASP868 3.5 107.3 1.0 NE2 D:GLN831 3.6 113.6 1.0 OE2 D:GLU1068 4.2 104.5 1.0 ND2 D:ASN865 4.2 113.6 1.0 CG D:GLU828 4.3 112.5 1.0 CA D:ASN865 4.3 113.6 1.0 CB D:ASN865 4.4 113.6 1.0 CG D:ASP868 4.5 107.3 1.0 CG D:GLN831 4.6 113.6 1.0 N D:ASN865 4.8 113.6 1.0 CB D:ASP868 4.8 107.3 1.0 CB D:GLN831 4.8 113.6 1.0 CE1 D:TYR859 4.8 118.2 1.0

J.Hu, S.J.Park, T.Walter, I.J.Orozco, G.O'dea, X.Ye, J.Du, W.Lu. Physiological Temperature Drives TRPM4 Ligand Recognition and Gating Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07436-7