Calcium in PDB 9cui: Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State

The binding sites of Calcium atom in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State (pdb code 9cui). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 7 binding sites of Calcium where determined in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State, PDB code: 9cui:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7;

Calcium binding site 1 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca816 b:99.4 occ:1.00 CA A:CA817 2.2 108.7 1.0 OD1 A:ASP542 2.6 28.4 1.0 OD1 C:ASP542 2.6 36.8 1.0 OD1 D:ASP542 2.6 38.4 1.0 OD1 B:ASP542 2.7 40.7 1.0 CG A:ASP542 3.7 28.4 1.0 CG D:ASP542 3.8 38.4 1.0 CG C:ASP542 3.8 36.8 1.0 CG B:ASP542 3.8 40.7 1.0 OD2 A:ASP542 4.3 28.4 1.0 OD2 B:ASP542 4.4 40.7 1.0 OD2 D:ASP542 4.4 38.4 1.0 OD2 C:ASP542 4.4 36.8 1.0 CA C:ASP542 4.8 36.8 1.0 CA D:ASP542 4.8 38.4 1.0 CB D:ASP542 4.8 38.4 1.0 CB C:ASP542 4.8 36.8 1.0 CB A:ASP542 4.9 28.4 1.0 CA A:ASP542 4.9 28.4 1.0 CB B:ASP542 5.0 40.7 1.0

Calcium binding site 2 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca817 b:108.7 occ:1.00 CA A:CA816 2.2 99.4 1.0 OD1 A:ASP542 3.9 28.4 1.0 CA B:CA814 3.9 103.7 1.0 OD1 B:ASP542 4.0 40.7 1.0 O A:THR539 4.0 22.4 1.0 O A:ILE540 4.3 21.5 1.0 OD1 C:ASP542 4.5 36.8 1.0 OD1 D:ASP542 4.6 38.4 1.0 O B:THR539 4.9 31.0 1.0

Calcium binding site 3 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca814 b:103.7 occ:1.00 OG1 C:THR539 3.8 29.1 1.0 CA A:CA817 3.9 108.7 1.0 O B:THR539 4.0 31.0 1.0 OG1 B:THR539 4.2 31.0 1.0 O C:THR539 4.3 29.1 1.0 CB C:THR539 4.4 29.1 1.0 OG1 D:THR539 4.8 33.6 1.0 CB B:THR539 4.9 31.0 1.0

Calcium binding site 4 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca401 b:96.6 occ:1.00 OE1 E:GLU31 2.5 75.0 1.0 O E:THR26 2.6 79.1 1.0 OD2 E:ASP22 2.6 75.0 1.0 CG2 E:THR28 3.0 76.7 1.0 CD E:GLU31 3.2 75.0 1.0 CG E:ASP22 3.3 75.0 1.0 N E:THR28 3.3 76.7 1.0 OD1 E:ASP22 3.3 75.0 1.0 OG1 E:THR28 3.5 76.7 1.0 C E:THR26 3.6 79.1 1.0 OE2 E:GLU31 3.7 75.0 1.0 CB E:THR28 3.7 76.7 1.0 OD1 E:ASP20 3.8 71.2 1.0 OG1 E:THR26 3.9 79.1 1.0 CG E:GLU31 4.0 75.0 1.0 CA E:ILE27 4.1 78.4 1.0 C E:ILE27 4.1 78.4 1.0 CA E:THR28 4.1 76.7 1.0 CB E:GLU31 4.2 75.0 1.0 N E:ILE27 4.3 78.4 1.0 OD1 E:ASP24 4.3 79.2 1.0 CB E:ASP22 4.6 75.0 1.0 CB E:THR26 4.7 79.1 1.0 CA E:THR26 4.8 79.1 1.0 CG E:ASP20 4.9 71.2 1.0

Calcium binding site 5 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca402 b:129.7 occ:1.00 OD2 E:ASP58 2.6 89.0 1.0 O E:THR62 2.6 87.4 1.0 OE1 E:GLU67 2.6 82.0 1.0 OD1 E:ASN60 2.9 89.9 1.0 OD1 E:ASP58 3.0 89.0 1.0 ND2 E:ASN60 3.0 89.9 1.0 CG E:ASP58 3.1 89.0 1.0 OD2 E:ASP64 3.2 82.5 1.0 CG E:ASN60 3.3 89.9 1.0 CD E:GLU67 3.4 82.0 1.0 N E:ASP64 3.4 82.5 1.0 CG E:ASP64 3.5 82.5 1.0 C E:THR62 3.7 87.4 1.0 CB E:ASP64 3.7 82.5 1.0 OE2 E:GLU67 3.9 82.0 1.0 OD1 E:ASP56 4.0 91.4 1.0 OD1 E:ASP64 4.2 82.5 1.0 CA E:ASP64 4.2 82.5 1.0 CA E:ILE63 4.2 83.1 1.0 C E:ILE63 4.2 83.1 1.0 CG E:GLU67 4.3 82.0 1.0 N E:ILE63 4.4 83.1 1.0 OG1 E:THR62 4.5 87.4 1.0 CB E:ASP58 4.5 89.0 1.0 CB E:GLU67 4.6 82.0 1.0 CG E:ASP56 4.8 91.4 1.0 CA E:THR62 4.8 87.4 1.0 CB E:ASN60 4.8 89.9 1.0 N E:THR62 4.9 87.4 1.0 OD2 E:ASP56 5.0 91.4 1.0

Calcium binding site 6 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca403 b:82.4 occ:1.00 O E:TYR99 2.5 64.5 1.0 OD1 E:ASP95 2.6 62.9 1.0 OD1 E:ASN97 2.6 63.4 1.0 OE1 E:GLU104 2.6 54.9 1.0 OE2 E:GLU104 2.7 54.9 1.0 OD1 E:ASP93 3.0 65.4 1.0 CD E:GLU104 3.0 54.9 1.0 ND2 E:ASN97 3.3 63.4 1.0 CG E:ASN97 3.3 63.4 1.0 C E:TYR99 3.6 64.5 1.0 CG E:ASP95 3.6 62.9 1.0 OG E:SER101 3.8 58.4 1.0 OD2 E:ASP95 4.0 62.9 1.0 CG E:ASP93 4.1 65.4 1.0 CA E:TYR99 4.5 64.5 1.0 CA E:ILE100 4.5 60.2 1.0 CG E:GLU104 4.5 54.9 1.0 N E:ILE100 4.5 60.2 1.0 N E:TYR99 4.5 64.5 1.0 CB E:TYR99 4.5 64.5 1.0 OD2 E:ASP93 4.7 65.4 1.0 N E:ASP95 4.7 62.9 1.0 C E:ILE100 4.7 60.2 1.0 N E:SER101 4.8 58.4 1.0 CB E:ASN97 4.8 63.4 1.0 CB E:SER101 4.9 58.4 1.0 CB E:ASP95 5.0 62.9 1.0

Calcium binding site 7 out of 7 in the Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Human Full-Length Ancestral TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca404 b:86.4 occ:1.00 OE2 E:GLU140 2.6 72.1 1.0 OD1 E:ASP133 2.6 64.8 1.0 O E:GLN135 2.6 62.3 1.0 OD1 E:ASP131 2.6 66.0 1.0 OD1 E:ASN137 2.6 67.3 1.0 OE1 E:GLU140 2.7 72.1 1.0 CD E:GLU140 2.9 72.1 1.0 OD1 E:ASP129 2.9 64.5 1.0 OD2 E:ASP133 3.1 64.8 1.0 CG E:ASP133 3.1 64.8 1.0 CG E:ASP131 3.5 66.0 1.0 CG E:ASN137 3.5 67.3 1.0 OD2 E:ASP131 3.7 66.0 1.0 C E:GLN135 3.7 62.3 1.0 CG E:ASP129 3.9 64.5 1.0 N E:ASN137 4.0 67.3 1.0 ND2 E:ASN137 4.2 67.3 1.0 CG E:GLU140 4.2 72.1 1.0 NH2 C:ARG643 4.3 132.4 1.0 CA E:VAL136 4.4 61.8 1.0 OD2 E:ASP129 4.4 64.5 1.0 CB E:ASN137 4.5 67.3 1.0 N E:VAL136 4.5 61.8 1.0 C E:VAL136 4.5 61.8 1.0 CB E:ASP133 4.5 64.8 1.0 N E:GLN135 4.7 62.3 1.0 N E:ILE130 4.7 63.5 1.0 N E:ASP131 4.7 66.0 1.0 CA E:GLN135 4.7 62.3 1.0 N E:ASP133 4.7 64.8 1.0 CA E:ASP129 4.8 64.5 1.0 CA E:ASN137 4.8 67.3 1.0 CB E:ASP129 4.9 64.5 1.0 CB E:ASP131 4.9 66.0 1.0 N E:GLY132 5.0 66.6 1.0

A.Neuberger, K.D.Nadezhdin, A.I.Sobolevsky. Structure-Function Analyses of Human Oncochannel TRPV6 Variants Associated with A Racial Divergence in Susceptibility to Cancer Structure 2024.
ISSN: ISSN 0969-2126
DOI: 10.1016/J.STR.2024.10.018