Calcium in PDB 9cuk: Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State

The binding sites of Calcium atom in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State (pdb code 9cuk). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 7 binding sites of Calcium where determined in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State, PDB code: 9cuk:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7;

Calcium binding site 1 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca815 b:120.1 occ:1.00 OD1 D:ASP542 2.5 47.1 1.0 OD1 B:ASP542 2.5 45.5 1.0 OD1 C:ASP542 2.6 39.2 1.0 OD1 A:ASP542 2.6 40.5 1.0 CA B:CA815 3.4 118.4 1.0 CG D:ASP542 3.7 47.1 1.0 CG B:ASP542 3.7 45.5 1.0 CG C:ASP542 3.7 39.2 1.0 CG A:ASP542 3.8 40.5 1.0 OD2 B:ASP542 4.2 45.5 1.0 OD2 D:ASP542 4.2 47.1 1.0 OD2 C:ASP542 4.2 39.2 1.0 OD2 A:ASP542 4.3 40.5 1.0 CB D:ASP542 4.9 47.1 1.0 CB B:ASP542 4.9 45.5 1.0 CB C:ASP542 4.9 39.2 1.0 CB A:ASP542 5.0 40.5 1.0 CA D:ASP542 5.0 47.1 1.0

Calcium binding site 2 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca815 b:118.4 occ:1.00 CA A:CA815 3.4 120.1 1.0 O B:THR539 3.6 38.1 1.0 O A:ILE540 3.7 30.7 1.0 O A:THR539 3.7 32.8 1.0 OD1 B:ASP542 4.0 45.5 1.0 O B:ILE541 4.3 37.5 1.0 C A:ILE540 4.4 30.7 1.0 C B:THR539 4.4 38.1 1.0 CA A:ILE540 4.4 30.7 1.0 CB B:THR539 4.7 38.1 1.0 CA B:ASP542 4.7 45.5 1.0 C A:THR539 4.8 32.8 1.0 C B:ILE541 4.8 37.5 1.0 O B:ILE540 4.9 36.6 1.0

Calcium binding site 3 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca816 b:102.6 occ:1.00 OG1 B:THR539 3.8 38.1 1.0 OG1 C:THR539 4.0 30.1 1.0 O B:THR539 4.2 38.1 1.0 CB C:THR539 4.7 30.1 1.0 CB B:THR539 4.8 38.1 1.0 O C:THR539 5.0 30.1 1.0

Calcium binding site 4 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca401 b:143.7 occ:1.00 O E:THR26 2.5 53.2 1.0 OD2 E:ASP22 2.5 52.3 1.0 OE2 E:GLU31 2.6 58.3 1.0 CD E:GLU31 2.8 58.3 1.0 OD1 E:ASP22 2.9 52.3 1.0 OD1 E:ASP20 2.9 50.9 1.0 CG E:ASP22 3.0 52.3 1.0 OE1 E:GLU31 3.0 58.3 1.0 OD1 E:ASP24 3.4 50.9 1.0 OG1 E:THR26 3.5 53.2 1.0 CG E:GLU31 3.7 58.3 1.0 C E:THR26 3.7 53.2 1.0 CG E:ASP20 4.0 50.9 1.0 OG1 E:THR28 4.2 56.1 1.0 CG E:ASP24 4.2 50.9 1.0 OD2 E:ASP24 4.2 50.9 1.0 CB E:ASP22 4.4 52.3 1.0 CB E:THR26 4.5 53.2 1.0 OD2 E:ASP20 4.5 50.9 1.0 N E:THR28 4.5 56.1 1.0 CA E:THR26 4.6 53.2 1.0 CB E:GLU31 4.6 58.3 1.0 N E:ILE27 4.7 54.6 1.0 N E:THR26 4.7 53.2 1.0 CA E:ILE27 4.8 54.6 1.0 CB E:ASP20 4.9 50.9 1.0 CA E:ASP20 5.0 50.9 1.0

Calcium binding site 5 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca402 b:123.4 occ:1.00 OE1 E:GLU67 2.5 55.8 1.0 OD2 E:ASP58 2.5 65.2 1.0 OD1 E:ASP58 2.6 65.2 1.0 O E:THR62 2.7 57.7 1.0 CG E:ASP58 2.8 65.2 1.0 CD E:GLU67 2.9 55.8 1.0 OE2 E:GLU67 2.9 55.8 1.0 OD1 E:ASP56 2.9 66.4 1.0 OD1 E:ASN60 2.9 62.4 1.0 OD1 E:ASP64 3.3 52.5 1.0 ND2 E:ASN60 3.3 62.4 1.0 CG E:ASN60 3.5 62.4 1.0 CG E:ASP64 3.7 52.5 1.0 CG E:ASP56 3.8 66.4 1.0 C E:THR62 3.9 57.7 1.0 N E:ASP64 4.0 52.5 1.0 OD2 E:ASP64 4.1 52.5 1.0 CG E:GLU67 4.1 55.8 1.0 CB E:ASP58 4.3 65.2 1.0 OD2 E:ASP56 4.3 66.4 1.0 CA E:ILE63 4.3 56.2 1.0 CB E:ASP64 4.5 52.5 1.0 N E:ILE63 4.6 56.2 1.0 C E:ILE63 4.6 56.2 1.0 CB E:GLU67 4.7 55.8 1.0 N E:ASP58 4.8 65.2 1.0 N E:THR62 4.8 57.7 1.0 OG1 E:THR62 4.9 57.7 1.0 CA E:ASP64 4.9 52.5 1.0 CB E:ASN60 4.9 62.4 1.0 CB E:ASP56 4.9 66.4 1.0 CA E:ASP56 5.0 66.4 1.0 CA E:THR62 5.0 57.7 1.0

Calcium binding site 6 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca403 b:117.9 occ:1.00 O E:TYR99 2.5 48.7 1.0 OD1 E:ASP95 2.5 49.5 1.0 OE2 E:GLU104 2.6 49.0 1.0 OE1 E:GLU104 2.6 49.0 1.0 OD1 E:ASN97 2.6 46.9 1.0 OD1 E:ASP93 2.8 53.5 1.0 CD E:GLU104 2.9 49.0 1.0 ND2 E:ASN97 3.2 46.9 1.0 CG E:ASN97 3.3 46.9 1.0 CG E:ASP95 3.4 49.5 1.0 OD2 E:ASP95 3.6 49.5 1.0 C E:TYR99 3.7 48.7 1.0 CG E:ASP93 3.9 53.5 1.0 OG E:SER101 3.9 51.2 1.0 CG E:GLU104 4.3 49.0 1.0 OD2 E:ASP93 4.5 53.5 1.0 N E:ASP95 4.6 49.5 1.0 CA E:ILE100 4.6 49.6 1.0 N E:ILE100 4.6 49.6 1.0 N E:LYS94 4.6 51.3 1.0 CA E:TYR99 4.6 48.7 1.0 CB E:ASN97 4.7 46.9 1.0 N E:TYR99 4.7 48.7 1.0 CB E:ASP95 4.8 49.5 1.0 CB E:TYR99 4.8 48.7 1.0 N E:ASN97 4.8 46.9 1.0 N E:SER101 4.8 51.2 1.0 CB E:SER101 4.9 51.2 1.0 CA E:ASP93 4.9 53.5 1.0 C E:ILE100 4.9 49.6 1.0 CB E:ASP93 4.9 53.5 1.0

Calcium binding site 7 out of 7 in the Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Human Full-Length Derived TRPV6 Channel in Calmodulin- Bound State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca404 b:121.6 occ:1.00 O E:GLN135 2.5 57.1 1.0 OD1 E:ASP131 2.6 63.1 1.0 OD1 E:ASP133 2.8 60.6 1.0 OE2 E:GLU140 3.1 61.2 1.0 OE1 E:GLU140 3.2 61.2 1.0 OD1 E:ASP129 3.2 56.5 1.0 OD1 E:ASN137 3.4 59.5 1.0 CD E:GLU140 3.5 61.2 1.0 ND2 E:ASN137 3.5 59.5 1.0 CG E:ASP131 3.5 63.1 1.0 C E:GLN135 3.7 57.1 1.0 CG E:ASP133 3.7 60.6 1.0 CG E:ASN137 3.7 59.5 1.0 OD2 E:ASP131 3.8 63.1 1.0 OD2 E:ASP133 4.0 60.6 1.0 N E:GLY132 4.3 59.7 1.0 N E:ASN137 4.3 59.5 1.0 N E:ASP133 4.3 60.6 1.0 CA E:VAL136 4.4 54.3 1.0 CG E:ASP129 4.4 56.5 1.0 N E:VAL136 4.4 54.3 1.0 CA E:GLN135 4.6 57.1 1.0 C E:VAL136 4.6 54.3 1.0 N E:GLN135 4.6 57.1 1.0 C E:GLY132 4.7 59.7 1.0 CG E:GLU140 4.8 61.2 1.0 CA E:GLY132 4.8 59.7 1.0 CB E:ASN137 4.8 59.5 1.0 CB E:ASP133 4.9 60.6 1.0 CB E:GLN135 4.9 57.1 1.0 N E:ASP131 4.9 63.1 1.0 CB E:ASP131 4.9 63.1 1.0

A.Neuberger, K.D.Nadezhdin, A.I.Sobolevsky. Structure-Function Analyses of Human Oncochannel TRPV6 Variants Associated with A Racial Divergence in Susceptibility to Cancer Structure 2024.
ISSN: ISSN 0969-2126
DOI: 10.1016/J.STR.2024.10.018