Calcium in PDB 1de4: Hemochromatosis Protein Hfe Complexed with Transferrin Receptor

The structure of Hemochromatosis Protein Hfe Complexed with Transferrin Receptor, PDB code: 1de4 was solved by M.J.Bennett, J.A.Lebron, P.J.Bjorkman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	110.400, 144.400, 327.100, 90.00, 93.60, 90.00
R / Rfree (%)	23.1 / 26.5

The binding sites of Calcium atom in the Hemochromatosis Protein Hfe Complexed with Transferrin Receptor (pdb code 1de4). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Hemochromatosis Protein Hfe Complexed with Transferrin Receptor, PDB code: 1de4:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Hemochromatosis Protein Hfe Complexed with Transferrin Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Hemochromatosis Protein Hfe Complexed with Transferrin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca801 b:47.7 occ:1.00 OE1 C:GLU465 2.3 41.8 1.0 OE1 C:GLU468 2.3 45.0 1.0 O C:PHE313 2.4 48.2 1.0 O C:THR310 2.4 59.4 1.0 OE2 C:GLU465 2.7 44.5 1.0 OG1 C:THR310 2.8 44.6 1.0 CD C:GLU465 2.8 56.0 1.0 C C:THR310 3.4 51.3 1.0 CB C:THR310 3.4 38.9 1.0 CD C:GLU468 3.5 54.4 1.0 C C:PHE313 3.5 41.1 1.0 O C:ASP307 3.9 50.0 1.0 CA C:THR310 4.0 49.0 1.0 OE2 C:GLU468 4.0 62.2 1.0 N C:PHE313 4.1 36.4 1.0 OG C:SER315 4.3 31.1 1.0 N C:ASP307 4.3 53.4 1.0 CG C:GLU465 4.3 45.2 1.0 CA C:PRO314 4.3 31.4 1.0 CB C:ASP307 4.3 52.0 1.0 N C:PRO314 4.4 37.6 1.0 N C:PRO311 4.4 52.9 1.0 N C:SER315 4.5 24.1 1.0 CA C:PHE313 4.5 37.6 1.0 N C:GLY312 4.5 44.8 1.0 C C:PRO314 4.6 37.2 1.0 CA C:PRO311 4.7 49.7 1.0 N C:THR310 4.7 46.5 1.0 CG C:GLU468 4.7 54.3 1.0 CA C:ASP307 4.8 50.5 1.0 CG2 C:THR310 4.8 42.2 1.0 C C:ASP307 4.8 49.6 1.0 C C:PRO311 4.9 44.0 1.0 CA C:GLU465 4.9 47.1 1.0 CB C:GLU468 4.9 41.7 1.0

Calcium binding site 2 out of 3 in the Hemochromatosis Protein Hfe Complexed with Transferrin Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Hemochromatosis Protein Hfe Complexed with Transferrin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca802 b:45.0 occ:1.00 OE1 F:GLU465 2.2 39.7 1.0 O F:PHE313 2.4 40.1 1.0 O F:THR310 2.4 51.6 1.0 OE1 F:GLU468 2.5 52.5 1.0 OE2 F:GLU465 2.7 41.5 1.0 OG1 F:THR310 2.7 52.8 1.0 CD F:GLU465 2.7 53.4 1.0 CB F:THR310 3.4 47.4 1.0 C F:THR310 3.4 49.0 1.0 C F:PHE313 3.6 43.0 1.0 CD F:GLU468 3.7 57.9 1.0 O F:ASP307 3.9 47.1 1.0 CA F:THR310 4.0 48.4 1.0 OG F:SER315 4.1 36.4 1.0 N F:PHE313 4.2 42.5 1.0 OE2 F:GLU468 4.2 63.7 1.0 CB F:ASP307 4.2 50.5 1.0 CG F:GLU465 4.2 41.2 1.0 N F:ASP307 4.3 55.8 1.0 CA F:PRO314 4.3 28.9 1.0 N F:PRO314 4.4 44.1 1.0 N F:SER315 4.4 37.6 1.0 N F:PRO311 4.4 48.5 1.0 CA F:PHE313 4.6 44.8 1.0 C F:PRO314 4.6 31.7 1.0 N F:THR310 4.6 48.5 1.0 CA F:ASP307 4.7 50.9 1.0 CG2 F:THR310 4.7 40.2 1.0 N F:GLY312 4.7 47.9 1.0 C F:ASP307 4.7 51.4 1.0 CA F:PRO311 4.7 43.6 1.0 CG F:GLU468 4.8 58.4 1.0 CA F:GLU465 4.9 44.0 1.0 C F:PRO311 5.0 42.5 1.0

Calcium binding site 3 out of 3 in the Hemochromatosis Protein Hfe Complexed with Transferrin Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Hemochromatosis Protein Hfe Complexed with Transferrin Receptor within 5.0Å range: probe atom residue distance (Å) B Occ I:Ca803 b:32.9 occ:1.00 O I:PHE313 2.3 33.0 1.0 OE1 I:GLU465 2.3 21.0 1.0 OE1 I:GLU468 2.4 37.9 1.0 O I:THR310 2.4 46.7 1.0 OE2 I:GLU465 2.7 35.7 1.0 OG1 I:THR310 2.8 36.8 1.0 CD I:GLU465 2.9 34.7 1.0 C I:THR310 3.4 39.9 1.0 CB I:THR310 3.4 32.6 1.0 C I:PHE313 3.5 32.5 1.0 CD I:GLU468 3.5 39.5 1.0 O I:ASP307 4.0 33.9 1.0 CA I:THR310 4.0 37.6 1.0 N I:PHE313 4.0 28.1 1.0 OE2 I:GLU468 4.1 39.3 1.0 OG I:SER315 4.2 27.2 1.0 CA I:PRO314 4.3 20.7 1.0 N I:PRO314 4.3 31.0 1.0 N I:ASP307 4.4 34.7 1.0 CG I:GLU465 4.4 28.9 1.0 N I:PRO311 4.4 36.9 1.0 CB I:ASP307 4.4 32.4 1.0 CA I:PHE313 4.4 30.5 1.0 N I:SER315 4.5 24.1 1.0 N I:GLY312 4.5 32.6 1.0 C I:PRO314 4.6 25.2 1.0 CA I:PRO311 4.7 36.4 1.0 N I:THR310 4.7 38.2 1.0 CG I:GLU468 4.7 43.3 1.0 CG2 I:THR310 4.8 27.5 1.0 CA I:ASP307 4.8 31.2 1.0 C I:ASP307 4.8 32.2 1.0 C I:PRO311 4.8 32.1 1.0 CA I:GLU465 4.9 26.1 1.0 CB I:GLU468 4.9 25.2 1.0

M.J.Bennett, J.A.Lebron, P.J.Bjorkman. Crystal Structure of the Hereditary Haemochromatosis Protein Hfe Complexed with Transferrin Receptor. Nature V. 403 46 2000.
ISSN: ISSN 0028-0836
PubMed: 10638746
DOI: 10.1038/47417