Calcium in PDB 1ggu: Human Factor XIII with Calcium Bound in the Ion Site

All present enzymatic activity of Human Factor XIII with Calcium Bound in the Ion Site:
2.3.2.13;

The structure of Human Factor XIII with Calcium Bound in the Ion Site, PDB code: 1ggu was solved by B.A.Fox, V.C.Yee, L.C.Pederson, I.L.Trong, P.D.Bishop, R.E.Stenkamp, D.C.Teller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	100.172, 70.764, 133.822, 90.00, 106.11, 90.00
R / Rfree (%)	22.7 / 31.3

The binding sites of Calcium atom in the Human Factor XIII with Calcium Bound in the Ion Site (pdb code 1ggu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Factor XIII with Calcium Bound in the Ion Site, PDB code: 1ggu:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Factor XIII with Calcium Bound in the Ion Site


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Factor XIII with Calcium Bound in the Ion Site within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2001 b:58.1 occ:1.00 O A:HOH6438 2.1 39.0 1.0 O A:HOH6155 2.3 54.2 1.0 O A:ALA457 2.8 42.6 1.0 O A:HOH6437 2.9 46.5 1.0 C A:ALA457 3.6 41.5 1.0 O A:HOH6288 3.8 89.3 1.0 OE1 A:GLU485 3.9 75.5 1.0 OD1 A:ASP438 4.0 44.3 1.0 O A:ASN436 4.2 34.6 1.0 CA A:ALA457 4.2 41.5 1.0 O A:HOH6360 4.3 51.0 1.0 O A:SER437 4.3 32.1 1.0 CB A:ALA457 4.4 41.1 1.0 N A:THR458 4.4 41.4 1.0 O A:ILE460 4.5 36.1 1.0 C A:ASN436 4.5 31.1 1.0 O A:HOH6089 4.5 33.0 1.0 NZ A:LYS482 4.6 46.8 1.0 O A:HOH6283 4.6 37.8 1.0 CA A:ASN436 4.6 29.0 1.0 CA A:THR458 4.6 43.7 1.0 OE2 A:GLU490 4.7 54.9 1.0 O A:HOH6076 4.7 40.6 1.0 O A:VAL435 4.9 28.0 1.0 OD1 A:ASN436 4.9 30.9 1.0 C A:SER437 5.0 31.8 1.0

Calcium binding site 2 out of 2 in the Human Factor XIII with Calcium Bound in the Ion Site


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Factor XIII with Calcium Bound in the Ion Site within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca2002 b:45.9 occ:1.00 O B:HOH6135 2.5 30.5 1.0 O B:ALA457 2.5 42.9 1.0 O B:HOH6136 2.7 28.7 1.0 O B:HOH6293 2.8 47.2 1.0 O B:HOH6151 2.9 69.9 1.0 O B:HOH6322 3.7 63.9 1.0 C B:ALA457 3.8 40.0 1.0 NZ B:LYS482 4.1 33.1 1.0 OE2 B:GLU490 4.5 36.8 1.0 CG B:GLU485 4.5 69.5 1.0 CB B:ALA457 4.5 36.0 1.0 CA B:ALA457 4.6 37.2 1.0 OD1 B:ASP438 4.6 31.5 1.0 O B:ILE460 4.6 30.0 1.0 O B:ASN436 4.7 28.5 1.0 O B:HOH6324 4.7 33.2 1.0 N B:THR458 4.7 41.0 1.0 O B:SER437 4.8 26.5 1.0 OD1 B:ASN436 4.8 29.1 1.0 CA B:ASN436 4.9 25.2 1.0 O B:VAL435 4.9 24.4 1.0 CA B:THR458 4.9 39.8 1.0 C B:ASN436 5.0 26.5 1.0 O B:HOH6162 5.0 32.8 1.0

B.A.Fox, V.C.Yee, L.C.Pedersen, I.Le Trong, P.D.Bishop, R.E.Stenkamp, D.C.Teller. Identification of the Calcium Binding Site and A Novel Ytterbium Site in Blood Coagulation Factor XIII By X-Ray Crystallography. J.Biol.Chem. V. 274 4917 1999.
ISSN: ISSN 0021-9258
PubMed: 9988734
DOI: 10.1074/JBC.274.8.4917