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Calcium in PDB 1rx9: Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form)

Enzymatic activity of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form)

All present enzymatic activity of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form):
1.5.1.3;

Protein crystallography data

The structure of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form), PDB code: 1rx9 was solved by M.R.Sawaya, J.Kraut, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 34.409, 45.512, 99.199, 90.00, 90.00, 90.00
R / Rfree (%) 18.4 / n/a

Calcium Binding Sites:

The binding sites of Calcium atom in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form) (pdb code 1rx9). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form), PDB code: 1rx9:

Calcium binding site 1 out of 1 in 1rx9

Go back to Calcium Binding Sites List in 1rx9
Calcium binding site 1 out of 1 in the Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Dihydrofolate Reductase (E.C.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (Oxidized Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca300

b:24.4
occ:1.00
 OXT A:ARG159 2.4 14.2 1.0
O A:HOH390 2.4 38.8 1.0
O A:HOH370 2.5 13.3 1.0
O A:HOH391 2.6 46.5 1.0
C A:ARG159 3.5 11.6 1.0
CA A:ARG159 4.1 11.2 1.0
O A:ARG159 4.5 8.9 1.0
O A:ARG158 4.7 20.5 1.0
CB A:ARG159 4.9 25.4 1.0
O A:HOH399 5.0 47.7 1.0

Reference:

M.R.Sawaya, J.Kraut. Loop and Subdomain Movements in the Mechanism of Escherichia Coli Dihydrofolate Reductase: Crystallographic Evidence. Biochemistry V. 36 586 1997.
ISSN: ISSN 0006-2960
PubMed: 9012674
DOI: 10.1021/BI962337C
Page generated: Tue Jul 8 01:43:11 2025

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