Calcium in PDB 1xcx: Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

Enzymatic activity of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

All present enzymatic activity of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts:
3.2.1.1;

Protein crystallography data

The structure of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts, PDB code: 1xcx was solved by C.Li, A.Begum, S.Numao, K.H.Park, S.G.Withers, G.D.Brayer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	10.00 / 1.90
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	53.200, 69.200, 131.900, 90.00, 90.00, 90.00
*R / R_free (%)*	18.3 / 19.8

Other elements in 1xcx:

Chlorine

(Cl)

1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts (pdb code 1xcx). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts, PDB code: 1xcx:

Calcium binding site 1 out of 1 in 1xcx

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Calcium Binding Sites List in 1xcx

Calcium binding site 1 out of 1 in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca497 b:12.7 occ:1.00	OD1	A:ASN100	2.4	15.2	1.0
	O	A:HOH513	2.4	11.9	1.0
	O	A:HIS201	2.5	15.3	1.0
	O	A:ARG158	2.5	15.8	1.0
	OD1	A:ASP167	2.5	14.1	1.0
	OD2	A:ASP167	2.5	17.1	1.0
	O	A:HOH533	2.5	14.5	1.0
	O	A:HOH563	2.7	19.7	1.0
	CG	A:ASP167	2.8	16.0	1.0
	CG	A:ASN100	3.5	16.7	1.0
	C	A:ARG158	3.6	15.8	1.0
	C	A:HIS201	3.6	15.4	1.0
	ND2	A:ASN100	3.9	12.8	1.0
	CA	A:ARG158	4.2	16.7	1.0
	CB	A:HIS201	4.2	14.3	1.0
	CB	A:ASP167	4.3	14.9	1.0
	O	A:ASN100	4.4	16.4	1.0
	CA	A:HIS201	4.5	14.8	1.0
	O	A:HOH542	4.5	13.7	1.0
	ND2	A:ASN137	4.6	18.3	1.0
	O	A:CYS160	4.6	17.5	1.0
	N	A:MET202	4.6	14.8	1.0
	N	A:ASP159	4.6	16.3	1.0
	CA	A:MET202	4.7	14.0	1.0
	O	A:VAL157	4.8	16.7	1.0
	CG	A:MET202	4.8	14.5	1.0
	CB	A:ASN100	4.8	13.3	1.0
	O	A:LEU168	4.8	15.3	1.0
	CA	A:ASP159	4.8	17.2	1.0
	O	A:HOH514	4.9	13.3	1.0

Reference:

C.Li, A.Begum, S.Numao, K.H.Park, S.G.Withers, G.D.Brayer. Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry V. 44 3347 2005.
ISSN: ISSN 0006-2960
PubMed: 15736945
DOI: 10.1021/BI048334E

Page generated: Tue Jul 8 03:25:01 2025

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