Calcium in PDB 2auh: Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase

All present enzymatic activity of Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase:
2.7.1.112;

The structure of Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase, PDB code: 2auh was solved by R.S.Depetris, J.Hu, I.Gimpelevich, L.J.Holt, R.J.Daly, S.R.Hubbard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.27 / 3.20
Space group	P 62
Cell size a, b, c (Å), α, β, γ (°)	127.182, 127.182, 65.925, 90.00, 90.00, 120.00
R / Rfree (%)	22.3 / 25.4

The binding sites of Calcium atom in the Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase (pdb code 2auh). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase, PDB code: 2auh:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1 b:55.9 occ:1.00 OD2 A:ASP1150 2.3 35.1 1.0 OD1 A:ASP1150 2.7 34.0 1.0 CA A:CA2 2.8 50.1 1.0 CG A:ASP1150 2.8 34.2 1.0 CB A:ASP1150 4.2 33.2 1.0 OD1 A:ASN1137 4.2 24.3 1.0 OE1 A:GLU1047 4.6 55.8 1.0 OE2 A:GLU1040 4.8 64.9 1.0 OD2 A:ASP1132 4.9 27.2 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the GRB14 Bps Region in Complex with the Insulin Receptor Tyrosine Kinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2 b:50.1 occ:1.00 CA A:CA1 2.8 55.9 1.0 OE1 A:GLU1047 2.9 55.8 1.0 OD2 A:ASP1150 3.3 35.1 1.0 OD1 A:ASP1150 3.5 34.0 1.0 CG A:ASP1150 3.7 34.2 1.0 CA A:GLY1152 3.9 34.4 1.0 OE2 A:GLU1040 3.9 64.9 1.0 O A:GLU1043 4.0 51.4 1.0 N A:GLY1152 4.0 32.9 1.0 CD A:GLU1047 4.0 55.6 1.0 CE1 A:PHE1007 4.6 86.1 1.0 C A:GLU1043 4.6 51.8 1.0 CB A:GLU1047 4.7 52.4 1.0 OE2 A:GLU1047 4.7 57.4 1.0 OE2 A:GLU1043 4.8 53.9 1.0 NZ A:LYS1030 4.9 64.5 1.0 CG A:GLU1047 4.9 54.8 1.0 CA A:PHE1044 4.9 51.1 1.0 CB A:GLU1043 5.0 53.2 1.0 CD1 A:PHE1007 5.0 85.5 1.0

R.S.Depetris, J.Hu, I.Gimpelevich, L.J.Holt, R.J.Daly, S.R.Hubbard. Structural Basis For Inhibition of the Insulin Receptor By the Adaptor Protein GRB14. Mol.Cell V. 20 325 2005.
ISSN: ISSN 1097-2765
PubMed: 16246733
DOI: 10.1016/J.MOLCEL.2005.09.001