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Calcium in PDB 2h2u: Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion

Enzymatic activity of Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion

All present enzymatic activity of Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion:
3.6.1.6;

Protein crystallography data

The structure of Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion, PDB code: 2h2u was solved by M.Yang, K.Horii, A.B.Herr, T.L.Kirley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.04 / 2.40
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 42.891, 52.412, 77.806, 100.94, 106.51, 99.32
R / Rfree (%) 21.6 / 28.5

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion (pdb code 2h2u). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion, PDB code: 2h2u:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 2h2u

Go back to Calcium Binding Sites List in 2h2u
Calcium binding site 1 out of 2 in the Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1000

b:47.4
occ:1.00
O A:SER275 2.3 29.8 1.0
O A:SER98 2.3 41.4 1.0
O A:GLU214 2.4 37.7 1.0
OD2 A:ASP99 2.7 44.2 1.0
O A:GLU145 2.8 36.0 1.0
O A:GLU326 2.9 43.4 1.0
CG A:ASP99 3.4 42.4 1.0
C A:SER98 3.5 40.6 1.0
C A:SER275 3.5 29.9 1.0
CB A:ASP99 3.6 39.6 1.0
C A:GLU214 3.7 38.1 1.0
C A:GLU145 4.0 36.3 1.0
CA A:ASP99 4.0 39.3 1.0
C A:GLU326 4.1 43.0 1.0
N A:ASP99 4.2 39.8 1.0
CB A:GLU214 4.4 37.6 1.0
OD1 A:ASP99 4.4 46.1 1.0
N A:SER276 4.5 29.1 1.0
CA A:SER276 4.5 29.4 1.0
CA A:SER275 4.5 29.4 1.0
CA A:GLU214 4.5 37.9 1.0
CB A:SER276 4.5 29.6 1.0
CB A:SER215 4.5 39.5 1.0
OG A:SER276 4.6 29.7 1.0
N A:SER215 4.6 39.1 1.0
CA A:SER98 4.6 41.0 1.0
CA A:TRP146 4.7 32.1 1.0
CA A:SER215 4.7 40.0 1.0
CB A:SER98 4.8 41.0 1.0
N A:TRP146 4.8 34.2 1.0
CB A:SER275 4.8 29.1 1.0
CA A:GLU326 4.9 43.6 1.0
OE1 A:GLU326 4.9 46.5 1.0
CB A:GLU326 4.9 43.7 1.0

Calcium binding site 2 out of 2 in 2h2u

Go back to Calcium Binding Sites List in 2h2u
Calcium binding site 2 out of 2 in the Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the E130Y Mutant of Human Soluble Calcium- Activated Nucleotidase (Scan) with Calcium Ion within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1001

b:57.3
occ:1.00
O B:SER275 2.4 36.1 1.0
O B:GLU214 2.7 41.2 1.0
O B:SER98 2.7 44.1 1.0
O B:GLU145 2.9 44.1 1.0
O B:GLU326 2.9 45.1 1.0
C B:SER275 3.6 36.7 1.0
CG B:ASP99 3.8 44.1 1.0
C B:SER98 3.9 43.8 1.0
C B:GLU214 3.9 41.1 1.0
OD2 B:ASP99 3.9 48.5 1.0
CB B:ASP99 4.0 41.2 1.0
OD1 B:ASP99 4.1 46.8 1.0
C B:GLU326 4.1 45.2 1.0
C B:GLU145 4.1 43.9 1.0
CG B:GLU326 4.3 49.2 1.0
CA B:ASP99 4.3 41.1 1.0
OG B:SER276 4.3 40.2 1.0
CB B:SER276 4.4 36.9 1.0
N B:SER276 4.5 36.3 1.0
CA B:SER276 4.5 36.0 1.0
CA B:SER275 4.6 37.0 1.0
N B:ASP99 4.6 42.3 1.0
CB B:SER215 4.7 41.9 1.0
CA B:TRP146 4.7 41.3 1.0
CB B:GLU214 4.7 40.6 1.0
CA B:SER215 4.8 42.1 1.0
CA B:GLU326 4.8 46.1 1.0
N B:SER215 4.8 41.4 1.0
CB B:GLU326 4.8 46.3 1.0
CA B:GLU214 4.8 40.4 1.0
N B:TRP146 4.9 42.7 1.0
CA B:SER98 4.9 44.7 1.0
CB B:SER275 5.0 37.0 1.0
CB B:TRP146 5.0 40.1 1.0

Reference:

M.Yang, K.Horii, A.B.Herr, T.L.Kirley. Calcium-Dependent Dimerization of Human Soluble Calcium Activated Nucleotidase: Characterization of the Dimer Interface. J.Biol.Chem. V. 281 28307 2006.
ISSN: ISSN 0021-9258
PubMed: 16835225
DOI: 10.1074/JBC.M604413200
Page generated: Tue Jul 8 05:55:04 2025

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