Calcium in PDB 2hck: Src Family Kinase Hck-Quercetin Complex

All present enzymatic activity of Src Family Kinase Hck-Quercetin Complex:
2.7.1.112;

The structure of Src Family Kinase Hck-Quercetin Complex, PDB code: 2hck was solved by F.Sicheri, I.Moarefi, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.00 / 3.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	73.500, 93.300, 176.900, 90.00, 90.00, 90.00
R / Rfree (%)	22.8 / 31.1

The binding sites of Calcium atom in the Src Family Kinase Hck-Quercetin Complex (pdb code 2hck). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Src Family Kinase Hck-Quercetin Complex, PDB code: 2hck:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Src Family Kinase Hck-Quercetin Complex


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Src Family Kinase Hck-Quercetin Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2 b:32.2 occ:1.00 O B:GLU524 2.7 28.9 1.0 OE1 A:GLU490 2.7 30.4 1.0 O B:PTR527 2.8 40.6 1.0 OE2 B:GLU524 3.0 44.9 1.0 OE2 A:GLU490 3.2 28.7 1.0 CD A:GLU490 3.3 29.4 1.0 CG B:GLN529 3.7 64.3 1.0 CD B:GLU524 3.8 41.9 1.0 C B:GLU524 3.8 30.0 1.0 OE1 B:GLN529 3.9 66.1 1.0 CD B:GLN529 3.9 65.7 1.0 CG B:GLU524 4.0 37.1 1.0 C B:PTR527 4.0 38.7 1.0 H B:GLN529 4.1 0.0 1.0 N B:GLN529 4.1 54.4 1.0 H A:GLU489 4.3 0.0 1.0 CB A:PRO488 4.3 35.5 1.0 C B:GLN528 4.4 53.0 1.0 H A:GLU490 4.4 0.0 1.0 H B:PTR527 4.4 0.0 1.0 CB B:GLN529 4.5 59.6 1.0 CA B:GLN529 4.5 56.5 1.0 CA B:GLU524 4.5 28.6 1.0 CG A:GLU490 4.7 27.5 1.0 CB B:GLU524 4.8 30.6 1.0 NE2 B:GLN529 4.8 63.3 1.0 O B:GLN528 4.9 55.5 1.0 CA B:GLN528 4.9 49.4 1.0 N B:GLN528 4.9 43.9 1.0 N B:SER525 4.9 31.6 1.0 OE1 B:GLU524 5.0 44.3 1.0 N A:GLU489 5.0 35.0 1.0

Calcium binding site 2 out of 2 in the Src Family Kinase Hck-Quercetin Complex


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Src Family Kinase Hck-Quercetin Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1 b:40.9 occ:1.00 O A:PTR527 2.6 42.4 1.0 OE1 B:GLU490 2.7 25.4 1.0 OE2 B:GLU490 2.8 26.0 1.0 O A:GLU524 2.8 25.1 1.0 CD B:GLU490 3.1 25.5 1.0 OE1 A:GLN529 3.7 82.1 1.0 C A:PTR527 3.7 41.8 1.0 CG A:GLN529 3.8 78.6 1.0 H A:PTR527 3.8 0.0 1.0 CD A:GLN529 3.9 81.3 1.0 H B:GLU489 3.9 0.0 1.0 OE2 A:GLU524 4.0 36.7 1.0 C A:GLU524 4.0 23.6 1.0 N A:GLN529 4.1 65.8 1.0 H B:GLU490 4.2 0.0 1.0 H A:GLN529 4.2 0.0 1.0 C A:GLN528 4.3 58.6 1.0 CB B:PRO488 4.5 53.6 1.0 CD A:GLU524 4.5 34.4 1.0 N A:PTR527 4.5 34.2 1.0 N A:GLN528 4.5 48.4 1.0 CA A:GLN528 4.6 53.2 1.0 CA A:PTR527 4.6 35.8 1.0 N B:GLU489 4.6 49.7 1.0 CA A:GLN529 4.6 72.7 1.0 O A:GLN528 4.6 58.6 1.0 CB A:PTR527 4.6 31.1 1.0 CG B:GLU490 4.7 26.6 1.0 CB A:GLN529 4.7 74.8 1.0 CG A:GLU524 4.7 28.7 1.0 CA A:GLU524 4.8 22.2 1.0 NE2 A:GLN529 4.9 80.5 1.0 CA A:SER525 4.9 25.8 1.0 CA B:PRO488 5.0 53.5 1.0

F.Sicheri, I.Moarefi, J.Kuriyan. Crystal Structure of the Src Family Tyrosine Kinase Hck. Nature V. 385 602 1997.
ISSN: ISSN 0028-0836
PubMed: 9024658
DOI: 10.1038/385602A0