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Calcium in PDB 2hu6: Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
Enzymatic activity of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
All present enzymatic activity of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor:
3.4.24.65;
3.4.24.65;
Protein crystallography data
The structure of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor, PDB code: 2hu6
was solved by
C.Mannino,
M.Nievo,
F.Machetti,
A.Papakyriakou,
V.Calderone,
M.Fragai,
A.Guarna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.68 / 1.32 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.250, 60.179, 53.974, 90.00, 114.59, 90.00 |
| R / Rfree (%) | 16.1 / 18.2 |
Other elements in 2hu6:
The structure of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
(pdb code 2hu6). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor, PDB code: 2hu6:
Jump to Calcium binding site number: 1; 2; 3;
In total 3 binding sites of Calcium where determined in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor, PDB code: 2hu6:
Jump to Calcium binding site number: 1; 2; 3;
Calcium binding site 1 out of 3 in 2hu6
Go back to
Calcium Binding Sites List in 2hu6
Calcium binding site 1 out
of 3 in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor within 5.0Å range:
|
Calcium binding site 2 out of 3 in 2hu6
Go back to
Calcium Binding Sites List in 2hu6
Calcium binding site 2 out
of 3 in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor within 5.0Å range:
|
Calcium binding site 3 out of 3 in 2hu6
Go back to
Calcium Binding Sites List in 2hu6
Calcium binding site 3 out
of 3 in the Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Crystal Structure of Human Mmp-12 in Complex with Acetohydroxamic Acid and A Bicyclic Inhibitor within 5.0Å range:
|
Reference:
C.Mannino,
M.Nievo,
F.Machetti,
A.Papakyriakou,
V.Calderone,
M.Fragai,
A.Guarna.
Synthesis of Bicyclic Molecular Scaffolds (Btaa): An Investigation Towards New Selective Mmp-12 Inhibitors. Bioorg.Med.Chem. V. 14 7392 2006.
ISSN: ISSN 0968-0896
PubMed: 16899369
DOI: 10.1016/J.BMC.2006.07.028
Page generated: Tue Jul 8 06:04:41 2025
ISSN: ISSN 0968-0896
PubMed: 16899369
DOI: 10.1016/J.BMC.2006.07.028
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