Calcium in PDB 2hyw: Human Annexin A2 with Calcium Bound

The structure of Human Annexin A2 with Calcium Bound, PDB code: 2hyw was solved by C.Shao, J.F.Head, B.A.Seaton, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	60.509, 64.283, 104.158, 90.00, 91.73, 90.00
R / Rfree (%)	21.4 / 25.7

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 14;

Binding sites:

The binding sites of Calcium atom in the Human Annexin A2 with Calcium Bound (pdb code 2hyw). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 14 binding sites of Calcium where determined in the Human Annexin A2 with Calcium Bound, PDB code: 2hyw:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Calcium binding site 1 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca501 b:36.6 occ:1.00 O A:VAL50 2.4 35.8 1.0 O A:HOH713 2.4 39.0 1.0 O A:HOH708 2.5 49.9 1.0 OE1 A:GLU52 2.5 32.6 1.0 O A:GLY49 2.5 37.8 1.0 O A:HOH626 2.6 48.7 1.0 OE2 A:GLU52 2.6 29.4 1.0 CD A:GLU52 2.9 30.6 1.0 C A:GLY49 3.4 36.4 1.0 C A:VAL50 3.5 33.3 1.0 N A:VAL50 4.1 35.2 1.0 O A:HOH603 4.1 35.1 1.0 CA A:VAL50 4.2 33.7 1.0 CA A:GLY49 4.3 37.6 1.0 CB A:VAL50 4.3 33.2 1.0 CG A:GLU52 4.4 28.1 1.0 N A:ASP51 4.6 32.1 1.0 N A:GLU52 4.6 29.9 1.0 O A:HOH722 4.7 49.3 1.0 CA A:ASP51 4.8 31.6 1.0

Calcium binding site 2 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca502 b:32.5 occ:1.00 O A:LEU90 2.2 26.1 1.0 O A:HOH550 2.3 37.9 1.0 O A:HOH716 2.3 30.3 1.0 O A:LYS87 2.3 27.9 1.0 OE2 A:GLU95 2.4 28.3 1.0 O A:HOH642 3.1 40.6 1.0 CD A:GLU95 3.3 27.5 1.0 C A:LEU90 3.4 28.4 1.0 OE1 A:GLU95 3.6 27.0 1.0 C A:LYS87 3.6 29.5 1.0 CA A:SER91 4.0 28.1 1.0 N A:SER91 4.1 28.3 1.0 CB A:SER91 4.3 26.6 1.0 O A:SER88 4.4 29.6 1.0 N A:LEU90 4.4 28.4 1.0 N A:SER88 4.5 28.7 1.0 CA A:SER88 4.5 28.5 1.0 C A:SER88 4.5 28.6 1.0 CA A:LEU90 4.5 28.0 1.0 CA A:LYS87 4.5 29.2 1.0 CG A:GLU95 4.7 24.3 1.0 CG A:LYS87 4.7 34.5 1.0

Calcium binding site 3 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca503 b:38.4 occ:1.00 O A:GLY119 2.3 47.7 1.0 O A:MET117 2.3 38.1 1.0 O A:HOH707 2.3 51.3 1.0 OD1 A:ASP161 2.3 31.8 1.0 O A:HOH717 2.5 37.3 1.0 O A:GLY121 2.6 39.7 1.0 OD2 A:ASP161 2.6 33.5 1.0 CG A:ASP161 2.8 33.8 1.0 C A:MET117 3.3 36.7 1.0 C A:GLY119 3.4 47.5 1.0 C A:GLY121 3.8 41.3 1.0 CA A:MET117 3.9 35.1 1.0 C A:LEU120 4.0 46.7 1.0 N A:GLY121 4.0 44.4 1.0 CA A:LEU120 4.1 47.9 1.0 C A:LYS118 4.2 43.8 1.0 O A:LYS118 4.2 44.3 1.0 N A:LEU120 4.2 48.0 1.0 N A:GLY119 4.3 45.4 1.0 CB A:ASP161 4.3 33.5 1.0 OG1 A:THR122 4.3 35.0 1.0 N A:LYS118 4.4 39.9 1.0 O A:LEU120 4.4 46.2 1.0 CB A:MET117 4.4 31.9 1.0 CA A:GLY119 4.5 46.6 1.0 CA A:GLY121 4.5 42.0 1.0 CA A:LYS118 4.7 43.5 1.0 N A:THR122 4.8 39.8 1.0 CA A:THR122 4.9 37.2 1.0 CA A:ASP161 5.0 34.2 1.0

Calcium binding site 4 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca504 b:40.8 occ:1.00 O A:HOH553 2.3 36.6 1.0 O A:HOH709 2.3 44.8 1.0 OE2 A:GLU124 2.4 39.0 1.0 O A:THR122 2.4 35.7 1.0 O A:HOH718 2.4 42.1 1.0 O A:HOH719 3.0 47.4 1.0 CD A:GLU124 3.1 38.1 1.0 OE1 A:GLU124 3.2 40.3 1.0 C A:THR122 3.6 35.4 1.0 N A:THR122 4.0 39.8 1.0 CA A:THR122 4.3 37.2 1.0 N A:GLU124 4.6 30.6 1.0 CG A:GLU124 4.6 36.4 1.0 N A:ASP123 4.6 34.2 1.0 CB A:THR122 4.8 36.6 1.0 CA A:ASP123 4.8 32.2 1.0 O A:HOH720 4.8 34.4 1.0

Calcium binding site 5 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca505 b:28.3 occ:1.00 OE1 A:GLU246 2.3 26.8 1.0 O A:GLY201 2.3 24.9 1.0 O A:HOH712 2.4 27.6 1.0 O A:ARG204 2.4 40.5 1.0 O A:GLY206 2.4 27.7 1.0 OE2 A:GLU246 2.5 23.1 1.0 CD A:GLU246 2.7 26.6 1.0 C A:GLY201 3.3 28.4 1.0 C A:GLY206 3.5 29.4 1.0 C A:ARG204 3.6 39.2 1.0 N A:GLY206 3.8 33.9 1.0 CA A:GLY201 4.0 25.2 1.0 N A:VAL202 4.1 29.5 1.0 OG1 A:THR207 4.1 30.8 1.0 N A:ARG204 4.2 38.0 1.0 CA A:GLY206 4.2 31.5 1.0 CG A:GLU246 4.2 25.7 1.0 CA A:VAL202 4.3 32.8 1.0 O A:HOH590 4.3 38.8 1.0 O A:VAL202 4.3 37.1 1.0 CG A:ARG204 4.4 41.0 1.0 C A:VAL202 4.4 35.7 1.0 CA A:ARG204 4.4 40.2 1.0 C A:LYS205 4.4 36.9 1.0 N A:LYS205 4.6 39.3 1.0 N A:THR207 4.6 28.3 1.0 O A:HOH627 4.7 34.7 1.0 CA A:LYS205 4.7 38.4 1.0 CA A:THR207 4.8 29.5 1.0

Calcium binding site 6 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca506 b:60.0 occ:1.00 O A:HOH714 2.3 36.4 1.0 O A:ARG244 2.4 26.5 1.0 O A:VAL247 2.5 29.0 1.0 O A:HOH682 2.7 42.4 1.0 O A:HOH695 2.9 43.5 1.0 OE1 A:GLU252 3.1 36.5 1.0 OE2 A:GLU252 3.2 35.3 1.0 CD A:GLU252 3.2 32.1 1.0 C A:ARG244 3.4 25.5 1.0 C A:VAL247 3.7 28.7 1.0 CA A:ARG244 3.8 25.1 1.0 CA A:LYS248 4.2 31.4 1.0 CB A:LYS248 4.2 33.9 1.0 CG A:GLU252 4.3 31.3 1.0 N A:LYS248 4.4 29.8 1.0 CB A:ARG244 4.6 25.4 1.0 O A:ILE243 4.6 24.6 1.0 N A:LYS245 4.6 25.7 1.0 N A:VAL247 4.7 26.6 1.0 CA A:VAL247 4.8 26.7 1.0 CB A:GLU252 4.9 28.1 1.0

Calcium binding site 7 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca507 b:21.8 occ:1.00 O A:HOH710 2.2 18.4 1.0 O A:GLY281 2.3 19.9 1.0 O A:MET277 2.4 18.4 1.0 O A:GLY279 2.4 19.5 1.0 OD2 A:ASP321 2.4 24.2 1.0 OD1 A:ASP321 2.5 19.3 1.0 CG A:ASP321 2.8 23.4 1.0 C A:MET277 3.4 18.9 1.0 C A:GLY281 3.5 21.8 1.0 C A:GLY279 3.6 22.4 1.0 N A:GLY281 3.9 21.4 1.0 CA A:MET277 4.0 19.6 1.0 C A:LYS280 4.1 21.2 1.0 CA A:GLY281 4.2 21.8 1.0 OG1 A:THR282 4.3 20.0 1.0 CB A:ASP321 4.3 24.5 1.0 N A:GLY279 4.3 22.5 1.0 O A:HOH557 4.3 34.4 1.0 C A:LYS278 4.3 22.7 1.0 O A:LYS280 4.5 23.4 1.0 O A:LYS278 4.5 22.1 1.0 N A:LYS278 4.5 19.8 1.0 CA A:GLY279 4.5 21.6 1.0 N A:THR282 4.6 20.1 1.0 N A:LYS280 4.6 21.4 1.0 CB A:MET277 4.6 17.1 1.0 CA A:LYS280 4.6 22.9 1.0 CA A:THR282 4.8 19.5 1.0 O A:HOH509 4.8 14.8 1.0 CA A:LYS278 4.9 21.6 1.0 CA A:ASP321 4.9 25.0 1.0

Calcium binding site 8 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca508 b:34.3 occ:1.00 O B:HOH725 2.3 37.2 1.0 O B:HOH724 2.3 31.9 1.0 O B:VAL50 2.4 28.6 1.0 O B:GLY49 2.5 32.7 1.0 OE1 B:GLU52 2.5 31.0 1.0 OE2 B:GLU52 2.7 32.6 1.0 O B:HOH584 2.7 36.0 1.0 CD B:GLU52 2.9 31.2 1.0 C B:GLY49 3.3 32.5 1.0 C B:VAL50 3.5 28.3 1.0 N B:VAL50 4.1 31.4 1.0 O B:HOH615 4.1 38.4 1.0 CA B:VAL50 4.2 29.1 1.0 CA B:GLY49 4.3 34.5 1.0 CB B:VAL50 4.3 29.6 1.0 CG B:GLU52 4.4 28.6 1.0 O B:HOH733 4.4 39.9 1.0 N B:GLU52 4.6 28.4 1.0 N B:ASP51 4.6 28.0 1.0 CA B:ASP51 4.9 28.4 1.0 O B:HOH594 4.9 40.8 1.0 CG1 B:VAL50 5.0 26.5 1.0

Calcium binding site 9 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 9 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca509 b:31.4 occ:1.00 O B:LEU90 2.2 26.9 1.0 O B:HOH536 2.2 35.0 1.0 O B:LYS87 2.3 22.3 1.0 OE2 B:GLU95 2.4 28.2 1.0 O B:HOH650 2.4 28.7 1.0 CD B:GLU95 3.4 28.0 1.0 C B:LEU90 3.4 26.3 1.0 C B:LYS87 3.5 25.3 1.0 OE1 B:GLU95 3.7 31.5 1.0 CA B:SER91 4.0 26.4 1.0 N B:SER91 4.1 26.8 1.0 CB B:SER91 4.2 25.8 1.0 O B:SER88 4.3 24.7 1.0 N B:SER88 4.4 23.5 1.0 CA B:SER88 4.4 23.7 1.0 C B:SER88 4.5 24.4 1.0 CA B:LYS87 4.5 25.8 1.0 CA B:LEU90 4.5 25.5 1.0 N B:LEU90 4.5 26.1 1.0 CG B:GLU95 4.6 26.1 1.0 O B:HOH659 4.7 45.7 1.0 CG B:LYS87 4.7 34.4 1.0

Calcium binding site 10 out of 14 in the Human Annexin A2 with Calcium Bound


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 10 of Human Annexin A2 with Calcium Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca510 b:40.9 occ:1.00 O B:MET117 2.3 36.6 1.0 O B:GLY119 2.3 44.0 1.0 OD1 B:ASP161 2.4 34.0 1.0 OD2 B:ASP161 2.5 31.0 1.0 O B:HOH721 2.5 44.6 1.0 O B:HOH727 2.5 36.0 1.0 O B:GLY121 2.6 39.7 1.0 CG B:ASP161 2.7 33.3 1.0 C B:MET117 3.4 36.6 1.0 C B:GLY119 3.6 44.6 1.0 C B:GLY121 3.7 41.1 1.0 C B:LEU120 3.9 45.0 1.0 CA B:MET117 4.0 34.5 1.0 N B:GLY121 4.0 43.5 1.0 CA B:LEU120 4.1 45.8 1.0 OG1 B:THR122 4.2 37.1 1.0 O B:LYS118 4.2 42.9 1.0 CB B:ASP161 4.2 33.1 1.0 O B:LEU120 4.2 45.2 1.0 C B:LYS118 4.3 42.1 1.0 N B:LEU120 4.3 44.8 1.0 CB B:MET117 4.4 31.9 1.0 N B:GLY119 4.4 43.1 1.0 N B:LYS118 4.5 39.0 1.0 CA B:GLY121 4.5 41.6 1.0 CA B:GLY119 4.6 43.9 1.0 N B:THR122 4.7 39.3 1.0 CA B:LYS118 4.8 41.9 1.0 CA B:THR122 4.8 37.3 1.0 CA B:ASP161 4.9 33.2 1.0

C.Shao, F.Zhang, M.M.Kemp, R.J.Linhardt, D.M.Waisman, J.F.Head, B.A.Seaton. Crystallographic Analysis of Calcium-Dependent Heparin Binding to Annexin A2. J.Biol.Chem. V. 281 31689 2006.
ISSN: ISSN 0021-9258
PubMed: 16882661
DOI: 10.1074/JBC.M604502200