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Atomistry » Calcium » PDB 2ovx-2p9k » 2p16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 2ovx-2p9k » 2p16 » |
Calcium in PDB 2p16: Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-CarboxamideEnzymatic activity of Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide
All present enzymatic activity of Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide, PDB code: 2p16
was solved by
R.Alexander,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide
(pdb code 2p16). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide, PDB code: 2p16: Calcium binding site 1 out of 1 in 2p16Go back to![]() ![]()
Calcium binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor Apixaban (Bms- 562247) Aka 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxo-1- Piperidinyl)Phenyl)-4,5,6,7-Tetrahydro-1H-Pyrazolo[3, 4- C]Pyridine-3-Carboxamide
![]() Mono view ![]() Stereo pair view
Reference:
D.J.Pinto,
M.J.Orwat,
S.Koch,
K.A.Rossi,
R.S.Alexander,
A.Smallwood,
P.C.Wong,
A.R.Rendina,
J.M.Luettgen,
R.M.Knabb,
K.He,
B.Xin,
R.R.Wexler,
P.Y.Lam.
Discovery of 1-(4-Methoxyphenyl)-7-Oxo-6-(4-(2-Oxopiperidin-1- Yl)Phenyl)-4,5,6,7-Tetrahydro- 1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide (Apixaban, Bms-562247), A Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa. J.Med.Chem. V. 50 5339 2007.
Page generated: Fri Jul 12 14:55:44 2024
ISSN: ISSN 0022-2623 PubMed: 17914785 DOI: 10.1021/JM070245N |
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