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Atomistry » Calcium » PDB 2ovx-2p9k » 2p3t | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 2ovx-2p9k » 2p3t » |
Calcium in PDB 2p3t: Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-AmideEnzymatic activity of Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide
All present enzymatic activity of Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide:
3.4.21.6; Protein crystallography data
The structure of Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide, PDB code: 2p3t
was solved by
M.Adler,
M.Whitlow,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2p3t:
The structure of Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide
(pdb code 2p3t). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide, PDB code: 2p3t: Calcium binding site 1 out of 1 in 2p3tGo back to![]() ![]()
Calcium binding site 1 out
of 1 in the Crystal Structure of Human Factor Xa Complexed with 3- Chloro-4-(2-Methylamino-Imidazol-1-Ylmethyl)-Thiophene-2- Carboxylic Acid [4-Chloro-2-(5-Chloro-Pyridin-2- Ylcarbamoyl)-6-Methoxy-Phenyl]-Amide
![]() Mono view ![]() Stereo pair view
Reference:
B.Ye,
D.O.Arnaiz,
Y.L.Chou,
B.D.Griedel,
R.Karanjawala,
W.Lee,
M.M.Morrissey,
K.L.Sacchi,
S.T.Sakata,
K.J.Shaw,
S.C.Wu,
Z.Zhao,
M.Adler,
S.Cheeseman,
W.P.Dole,
J.Ewing,
R.Fitch,
D.Lentz,
A.Liang,
D.Light,
J.Morser,
J.Post,
G.Rumennik,
B.Subramanyam,
M.E.Sullivan,
R.Vergona,
J.Walters,
Y.X.Wang,
K.A.White,
M.Whitlow,
M.J.Kochanny.
Thiophene-Anthranilamides As Highly Potent and Orally Available Factor Xa Inhibitors. J.Med.Chem. V. 50 2967 2007.
Page generated: Fri Jul 12 14:59:07 2024
ISSN: ISSN 0022-2623 PubMed: 17536795 DOI: 10.1021/JM070125F |
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