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Calcium in PDB 2uzp: Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.

Enzymatic activity of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.

All present enzymatic activity of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.:
2.7.11.13;

Protein crystallography data

The structure of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma., PDB code: 2uzp was solved by A.C.W.Pike, A.Amos, C.Johansson, F.Sobott, P.Savitsky, G.Berridge, O.Fedorov, C.Umeano, F.Gorrec, G.Bunkoczi, J.Debreczeni, F.Von Delft, C.H.Arrowsmith, A.Edwards, J.Weigelt, M.Sundstrom, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 138.503, 138.503, 68.358, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 20.5

Other elements in 2uzp:

The structure of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. also contains other interesting chemical elements:

Cobalt (Co) 3 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. (pdb code 2uzp). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 9 binding sites of Calcium where determined in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma., PDB code: 2uzp:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Calcium binding site 1 out of 9 in 2uzp

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Calcium binding site 1 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1296

b:22.2
occ:1.00
 O A:TRP247 2.3 35.6 1.0
OD2 A:ASP193 2.4 32.5 1.0
OD1 A:ASP246 2.4 31.8 1.0
OD1 A:ASP248 2.4 42.0 1.0
O A:HOH2036 2.4 24.2 1.0
OD2 A:ASP187 2.5 35.1 1.0
OD1 A:ASP187 2.6 34.9 1.0
CG A:ASP187 2.8 36.1 1.0
CG A:ASP246 3.2 32.4 1.0
OD2 A:ASP246 3.2 35.9 1.0
C A:TRP247 3.4 32.6 1.0
CG A:ASP193 3.5 34.3 1.0
CG A:ASP248 3.6 34.1 1.0
CA A:CA1297 3.8 21.8 1.0
CB A:ASP193 3.9 33.6 1.0
CA A:ASP248 4.0 32.5 1.0
N A:ASP193 4.0 34.7 1.0
N A:ASP248 4.1 35.1 1.0
O A:HOH2136 4.2 39.0 1.0
CB A:ASP187 4.3 32.0 1.0
CB A:ASP248 4.4 32.5 1.0
O A:HOH2030 4.4 20.9 1.0
N A:TRP247 4.5 33.8 1.0
OD1 A:ASP193 4.5 34.9 1.0
C A:ASP246 4.5 34.6 1.0
OD2 A:ASP248 4.5 35.4 1.0
C A:SER192 4.5 32.5 1.0
CA A:TRP247 4.6 34.0 1.0
CB A:ASP246 4.6 33.5 1.0
CA A:ASP193 4.6 34.6 1.0
CA A:SER192 4.6 34.9 1.0
O A:ASP246 4.7 34.3 1.0
O C:HOH2129 4.8 31.6 1.0
O C:HOH2130 4.8 27.6 1.0
CE3 A:TRP247 4.9 38.7 1.0
O2 A:SO41299 5.0 36.5 1.0

Calcium binding site 2 out of 9 in 2uzp

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Calcium binding site 2 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1297

b:21.8
occ:1.00
 O A:MET186 2.3 33.4 1.0
OD2 A:ASP246 2.3 35.9 1.0
O2 A:SO41299 2.3 36.5 1.0
OD1 A:ASP187 2.4 34.9 1.0
OD2 A:ASP254 2.4 34.9 1.0
OD1 A:ASP248 2.5 42.0 1.0
OD2 A:ASP248 2.6 35.4 1.0
CG A:ASP248 2.9 34.1 1.0
C A:MET186 3.3 36.4 1.0
CG A:ASP246 3.5 32.4 1.0
CG A:ASP254 3.6 35.1 1.0
CG A:ASP187 3.6 36.1 1.0
S A:SO41299 3.7 37.5 1.0
CA A:CA1296 3.8 22.2 1.0
O B:HOH2075 4.1 22.6 1.0
N A:ASP187 4.1 34.2 1.0
CA A:ASP187 4.1 32.7 1.0
OD1 A:ASP246 4.1 31.8 1.0
CA A:CA1298 4.1 27.2 1.0
CB A:MET186 4.1 37.6 1.0
O1 A:SO41299 4.1 34.5 1.0
O4 A:SO41299 4.3 36.7 1.0
CB A:ASP254 4.3 35.3 1.0
CA A:MET186 4.3 36.0 1.0
CE B:MET186 4.4 36.9 1.0
OD1 A:ASP254 4.4 35.4 1.0
CB A:ASP248 4.4 32.5 1.0
OD2 A:ASP187 4.4 35.1 1.0
CB A:ASP187 4.5 32.0 1.0
O A:HOH2137 4.6 25.1 1.0
CB A:ASP246 4.6 33.5 1.0
O3 A:SO41299 4.6 24.7 1.0
O A:HOH2036 4.9 24.2 1.0
O A:HOH2136 5.0 39.0 1.0

Calcium binding site 3 out of 9 in 2uzp

Go back to Calcium Binding Sites List in 2uzp
Calcium binding site 3 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1298

b:27.2
occ:1.00
 O B:HOH2075 2.3 22.6 1.0
O A:ARG252 2.3 36.9 1.0
OD1 A:ASP254 2.4 35.4 1.0
OD2 A:ASP248 2.4 35.4 1.0
O B:HOH2076 2.4 21.8 1.0
OG A:SER251 2.5 33.9 1.0
CG A:ASP254 3.0 35.1 1.0
OD2 A:ASP254 3.0 34.9 1.0
CB A:SER251 3.5 34.3 1.0
C A:ARG252 3.5 35.0 1.0
CG A:ASP248 3.5 34.1 1.0
O2 A:SO41299 3.8 36.5 1.0
N A:ARG252 4.1 34.6 1.0
CB A:ASP248 4.1 32.5 1.0
CA A:CA1297 4.1 21.8 1.0
O1 A:SO41299 4.2 34.5 1.0
C A:SER251 4.2 36.2 1.0
CA A:ARG252 4.3 39.0 1.0
S A:SO41299 4.3 37.5 1.0
O3 A:SO41299 4.4 24.7 1.0
CB A:ASP254 4.4 35.3 1.0
C A:ASN253 4.4 35.7 1.0
CA A:SER251 4.5 35.7 1.0
N A:ASP254 4.5 34.7 1.0
N A:ASN253 4.5 34.1 1.0
OD1 A:ASP248 4.5 42.0 1.0
CB B:PHE255 4.5 32.8 1.0
N B:PHE255 4.6 33.3 1.0
O B:HOH2087 4.6 23.6 1.0
O A:SER251 4.6 34.5 1.0
CA A:ASN253 4.7 35.2 1.0
O B:PHE255 4.7 34.4 1.0
O A:ASN253 4.8 36.5 1.0
O B:HOH2074 4.8 38.8 1.0
CA A:ASP254 4.8 35.2 1.0
CB A:ARG252 4.9 36.8 1.0

Calcium binding site 4 out of 9 in 2uzp

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Calcium binding site 4 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1296

b:25.5
occ:1.00
 OD2 B:ASP248 2.3 30.7 1.0
O B:ARG252 2.4 32.2 1.0
O A:HOH2101 2.4 20.7 1.0
OD1 B:ASP254 2.5 32.1 1.0
O A:HOH2102 2.5 23.0 1.0
OG B:SER251 2.5 31.4 1.0
CG B:ASP254 3.1 35.5 1.0
OD2 B:ASP254 3.1 37.1 1.0
CG B:ASP248 3.5 29.7 1.0
C B:ARG252 3.5 34.1 1.0
CB B:SER251 3.6 30.2 1.0
O1 B:SO41299 4.0 29.6 1.0
N B:ARG252 4.0 36.3 1.0
CB B:ASP248 4.0 31.7 1.0
CA B:CA1298 4.1 20.9 1.0
O3 B:SO41299 4.2 34.9 1.0
C B:SER251 4.2 33.6 1.0
CA B:ARG252 4.3 35.2 1.0
C B:ASN253 4.4 37.1 1.0
N B:ASP254 4.4 34.7 1.0
CB B:ASP254 4.4 35.1 1.0
S B:SO41299 4.4 32.3 1.0
CA B:SER251 4.5 32.9 1.0
O2 B:SO41299 4.5 24.5 1.0
OD1 B:ASP248 4.5 37.5 1.0
N B:ASN253 4.5 33.7 1.0
O A:HOH2118 4.6 26.8 1.0
O B:SER251 4.6 33.2 1.0
CB A:PHE255 4.6 33.6 1.0
CA B:ASN253 4.6 35.4 1.0
N A:PHE255 4.6 37.5 1.0
O B:ASN253 4.7 35.8 1.0
CA B:ASP254 4.8 36.3 1.0
O A:HOH2100 4.8 43.2 1.0
O A:PHE255 4.9 35.5 1.0
CB B:ARG252 4.9 34.0 1.0

Calcium binding site 5 out of 9 in 2uzp

Go back to Calcium Binding Sites List in 2uzp
Calcium binding site 5 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1297

b:22.5
occ:1.00
 OD2 B:ASP193 2.2 35.7 1.0
O B:TRP247 2.4 33.3 1.0
OD1 B:ASP248 2.4 37.5 1.0
OD1 B:ASP246 2.5 31.3 1.0
OD2 B:ASP187 2.5 34.5 1.0
O B:HOH2028 2.5 25.1 1.0
OD1 B:ASP187 2.6 39.9 1.0
CG B:ASP187 2.9 35.9 1.0
CG B:ASP246 3.2 37.8 1.0
OD2 B:ASP246 3.3 34.5 1.0
CG B:ASP193 3.3 34.6 1.0
C B:TRP247 3.5 33.4 1.0
CG B:ASP248 3.6 29.7 1.0
CA B:CA1298 3.8 20.9 1.0
CB B:ASP193 3.9 33.7 1.0
CA B:ASP248 3.9 33.9 1.0
N B:ASP193 3.9 35.3 1.0
N B:ASP248 4.1 35.1 1.0
OD1 B:ASP193 4.3 36.2 1.0
CB B:ASP187 4.4 38.6 1.0
CB B:ASP248 4.4 31.7 1.0
O B:HOH2021 4.4 22.3 1.0
N B:TRP247 4.5 35.4 1.0
C B:ASP246 4.5 36.2 1.0
C B:SER192 4.5 33.5 1.0
CA B:ASP193 4.5 33.5 1.0
OD2 B:ASP248 4.5 30.7 1.0
CA B:TRP247 4.6 34.0 1.0
CA B:SER192 4.6 35.0 0.5
CB B:ASP246 4.6 36.5 1.0
CA B:SER192 4.6 34.3 0.5
O B:ASP246 4.7 35.1 1.0
O B:HOH2113 4.7 33.1 1.0
CE3 B:TRP247 4.9 35.9 1.0
O B:HOH2100 4.9 37.6 1.0
O B:HOH2114 5.0 26.5 1.0
CA B:ASP246 5.0 36.0 1.0

Calcium binding site 6 out of 9 in 2uzp

Go back to Calcium Binding Sites List in 2uzp
Calcium binding site 6 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1298

b:20.9
occ:1.00
 OD2 B:ASP246 2.3 34.5 1.0
OD2 B:ASP254 2.3 37.1 1.0
O B:MET186 2.4 35.9 1.0
OD1 B:ASP187 2.4 39.9 1.0
O1 B:SO41299 2.4 29.6 1.0
OD1 B:ASP248 2.5 37.5 1.0
OD2 B:ASP248 2.5 30.7 1.0
CG B:ASP248 2.9 29.7 1.0
C B:MET186 3.4 38.6 1.0
CG B:ASP254 3.4 35.5 1.0
CG B:ASP246 3.5 37.8 1.0
CG B:ASP187 3.6 35.9 1.0
S B:SO41299 3.7 32.3 1.0
CA B:CA1297 3.8 22.5 1.0
N B:ASP187 4.1 38.2 1.0
OD1 B:ASP246 4.1 31.3 1.0
CA B:ASP187 4.1 34.9 1.0
CA B:CA1296 4.1 25.5 1.0
O3 B:SO41299 4.1 34.9 1.0
CB B:MET186 4.1 35.7 1.0
O A:HOH2102 4.2 23.0 1.0
CB B:ASP254 4.2 35.1 1.0
CE A:MET186 4.3 32.5 1.0
OD1 B:ASP254 4.3 32.1 1.0
O4 B:SO41299 4.3 32.1 1.0
OD2 B:ASP187 4.4 34.5 1.0
CB B:ASP248 4.4 31.7 1.0
CA B:MET186 4.4 36.0 1.0
CB B:ASP187 4.4 38.6 1.0
CB B:ASP246 4.6 36.5 1.0
O B:HOH2102 4.7 26.3 1.0
O2 B:SO41299 4.7 24.5 1.0
O B:ASP246 5.0 35.1 1.0
O B:HOH2028 5.0 25.1 1.0

Calcium binding site 7 out of 9 in 2uzp

Go back to Calcium Binding Sites List in 2uzp
Calcium binding site 7 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1296

b:22.2
occ:1.00
 OD2 C:ASP193 2.3 35.1 1.0
O C:TRP247 2.3 32.6 1.0
OD1 C:ASP248 2.4 38.1 1.0
OD1 C:ASP246 2.4 34.1 1.0
O C:HOH2029 2.4 25.0 1.0
OD2 C:ASP187 2.5 34.1 1.0
OD1 C:ASP187 2.7 38.3 1.0
CG C:ASP187 2.9 37.9 1.0
CG C:ASP246 3.2 35.7 1.0
OD2 C:ASP246 3.3 32.1 1.0
CG C:ASP193 3.4 37.3 1.0
C C:TRP247 3.4 33.9 1.0
CG C:ASP248 3.6 31.4 1.0
CA C:CA1298 3.8 22.9 1.0
CA C:ASP248 3.9 34.2 1.0
CB C:ASP193 3.9 35.6 1.0
N C:ASP193 4.0 33.7 1.0
N C:ASP248 4.1 35.3 1.0
CB C:ASP248 4.3 32.5 1.0
O C:HOH2025 4.4 23.2 1.0
CB C:ASP187 4.4 33.7 1.0
N C:TRP247 4.4 33.8 1.0
C C:ASP246 4.4 33.4 1.0
OD1 C:ASP193 4.5 33.7 1.0
O C:HOH2115 4.5 40.4 1.0
OD2 C:ASP248 4.5 35.7 1.0
CA C:TRP247 4.5 34.3 1.0
CB C:ASP246 4.6 33.8 1.0
C C:SER192 4.6 33.7 1.0
CA C:ASP193 4.6 35.6 1.0
CA C:SER192 4.6 35.6 0.5
O C:ASP246 4.7 33.8 1.0
CA C:SER192 4.7 34.8 0.5
O C:HOH2131 4.8 33.9 1.0
CE3 C:TRP247 4.9 35.4 1.0
CA C:ASP246 4.9 33.9 1.0
O C:HOH2132 5.0 31.6 1.0

Calcium binding site 8 out of 9 in 2uzp

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Calcium binding site 8 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1297

b:28.4
occ:1.00
 O C:ARG252 2.3 33.0 1.0
OD2 C:ASP248 2.3 35.7 1.0
OD1 C:ASP254 2.5 33.3 1.0
OG C:SER251 2.5 31.5 1.0
CG C:ASP254 3.1 38.9 1.0
OD2 C:ASP254 3.1 35.2 1.0
CG C:ASP248 3.5 31.4 1.0
C C:ARG252 3.5 35.5 1.0
CB C:SER251 3.5 32.3 1.0
N C:ARG252 4.0 36.2 1.0
CB C:ASP248 4.0 32.5 1.0
O3 C:SO41299 4.0 32.9 1.0
O1 C:SO41299 4.0 45.9 1.0
C C:SER251 4.1 34.7 1.0
CA C:CA1298 4.2 22.9 1.0
CA C:ARG252 4.3 38.4 1.0
S C:SO41299 4.4 40.1 1.0
N C:ASP254 4.4 35.5 1.0
C C:ASN253 4.4 35.6 1.0
CA C:SER251 4.5 34.1 1.0
O4 C:SO41299 4.5 31.7 1.0
CB C:ASP254 4.5 36.0 1.0
OD1 C:ASP248 4.5 38.1 1.0
O C:HOH2081 4.5 22.1 1.0
N C:ASN253 4.5 32.3 1.0
O C:SER251 4.5 33.3 1.0
CA C:ASN253 4.6 33.8 1.0
O C:ASN253 4.8 34.4 1.0
CA C:ASP254 4.8 36.3 1.0
CB C:ARG252 4.9 36.7 1.0

Calcium binding site 9 out of 9 in 2uzp

Go back to Calcium Binding Sites List in 2uzp
Calcium binding site 9 out of 9 in the Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 9 of Crystal Structure of the C2 Domain of Human Protein Kinase C Gamma. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1298

b:22.9
occ:1.00
 OD2 C:ASP246 2.2 32.1 1.0
OD1 C:ASP187 2.4 38.3 1.0
O3 C:SO41299 2.4 32.9 1.0
O C:MET186 2.4 32.8 1.0
OD2 C:ASP254 2.5 35.2 1.0
OD1 C:ASP248 2.5 38.1 1.0
OD2 C:ASP248 2.6 35.7 1.0
CG C:ASP248 2.9 31.4 1.0
CG C:ASP246 3.4 35.7 1.0
C C:MET186 3.4 37.4 1.0
CG C:ASP187 3.6 37.9 1.0
CG C:ASP254 3.6 38.9 1.0
S C:SO41299 3.7 40.1 1.0
CA C:CA1296 3.8 22.2 1.0
O1 C:SO41299 4.0 45.9 1.0
OD1 C:ASP246 4.0 34.1 1.0
N C:ASP187 4.1 39.6 1.0
CB C:MET186 4.1 36.2 1.0
CA C:ASP187 4.1 35.8 1.0
CA C:CA1297 4.2 28.4 1.0
CB C:ASP254 4.3 36.0 1.0
O2 C:SO41299 4.4 50.2 1.0
OD2 C:ASP187 4.4 34.1 1.0
CB C:ASP248 4.4 32.5 1.0
CA C:MET186 4.4 37.6 1.0
OD1 C:ASP254 4.4 33.3 1.0
CB C:ASP187 4.4 33.7 1.0
CB C:ASP246 4.5 33.8 1.0
O C:HOH2116 4.7 30.9 1.0
O4 C:SO41299 4.8 31.7 1.0
O C:HOH2029 4.8 25.0 1.0
O C:ASP246 4.9 33.8 1.0

Reference:

A.C.W.Pike, A.Amos, C.Johansson, F.Sobott, P.Savitsky, G.Berridge, O.Fedorov, C.Umeano, F.Gorrec, G.Bunkoczi, J.Debreczeni, F.Von Delft, C.H.Arrowsmith, A.Edwards, J.Weigelt, M.Sundstrom, S.Knapp. Crystal Structure of C2 Domain of Protein Kinase C Gamma To Be Published.
Page generated: Tue Jul 8 08:28:14 2025

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