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Calcium in PDB 3c14: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca, PDB code: 3c14 was solved by T.-C.Mou, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.68
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 117.874, 132.997, 69.998, 90.00, 90.00, 90.00
R / Rfree (%) 24.5 / 29.1

Other elements in 3c14:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Chlorine (Cl) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca (pdb code 3c14). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca, PDB code: 3c14:

Calcium binding site 1 out of 1 in 3c14

Go back to Calcium Binding Sites List in 3c14
Calcium binding site 1 out of 1 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Ca within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca29

b:63.6
occ:1.00
 OD2 A:ASP440 2.1 67.5 1.0
O6 A:POP1 2.4 68.0 1.0
OD2 A:ASP396 2.7 73.8 1.0
O1 A:POP1 2.7 68.9 1.0
O2 A:POP1 3.0 68.5 1.0
O A:ILE397 3.1 57.2 1.0
CG A:ASP440 3.2 60.8 1.0
P1 A:POP1 3.3 67.5 1.0
CG A:ASP396 3.5 71.0 1.0
OD1 A:ASP396 3.5 75.5 1.0
OD1 A:ASP440 3.6 57.2 1.0
P2 A:POP1 3.7 66.0 1.0
O A:POP1 3.9 67.2 1.0
CB A:PHE400 4.2 71.8 1.0
C A:ILE397 4.2 58.1 1.0
CB A:ASP440 4.4 57.0 1.0
O5 A:POP1 4.4 68.1 1.0
N A:ILE397 4.5 54.3 1.0
CD2 A:PHE400 4.7 74.4 1.0
O3 A:POP1 4.7 68.3 1.0
O4 A:POP1 4.7 67.4 1.0
CG A:PHE400 4.8 73.7 1.0
CA A:ILE397 4.8 54.6 1.0
CB A:ASP396 4.9 63.7 1.0
NH2 A:ARG484 5.0 74.9 1.0

Reference:

T.C.Mou, N.Masada, D.M.Cooper, S.R.Sprang. Structural Basis For Inhibition of Mammalian Adenylyl Cyclase By Calcium. Biochemistry V. 48 3387 2009.
ISSN: ISSN 0006-2960
PubMed: 19243146
DOI: 10.1021/BI802122K
Page generated: Tue Jul 8 11:17:12 2025

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