Calcium in PDB 3d94: Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip

Enzymatic activity of Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip

All present enzymatic activity of Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip:
2.7.1.112; 2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip, PDB code: 3d94 was solved by J.Wu, W.Li, W.T.Miller, S.R.Hubbard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	35.65 / 2.30
*Space group*	H 3 2
*Cell size a, b, c (Å), α, β, γ (°)*	208.182, 208.182, 50.853, 90.00, 90.00, 120.00
*R / R_free (%)*	19.8 / 23.6

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip (pdb code 3d94). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip, PDB code: 3d94:

Calcium binding site 1 out of 1 in 3d94

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Calcium Binding Sites List in 3d94

Calcium binding site 1 out of 1 in the Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the Insulin-Like Growth Factor-1 Receptor Kinase in Complex with Pqip within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca2 b:30.5 occ:1.00	OE2	A:GLU1013	2.3	32.3	1.0
	OD2	A:ASP1129	2.4	26.9	1.0
	O	A:TYR1131	2.5	33.1	1.0
	OD1	A:ASP1129	2.5	27.8	1.0
	O	A:HOH1373	2.5	28.7	1.0
	O	A:HOH1366	2.7	30.2	1.0
	CG	A:ASP1129	2.8	27.6	1.0
	CD	A:GLU1013	3.5	35.5	1.0
	C	A:TYR1131	3.6	33.1	1.0
	OE1	A:GLU1013	4.1	36.8	1.0
	O	A:HOH1310	4.2	35.0	1.0
	N	A:TYR1131	4.3	32.4	1.0
	CA	A:TYR1131	4.3	32.8	1.0
	CB	A:ASP1129	4.3	27.9	1.0
	OE2	A:GLU1132	4.4	41.0	1.0
	CA	A:PHE980	4.4	23.5	1.0
	CB	A:TYR1131	4.4	32.8	1.0
	O	A:HOH1314	4.5	32.6	1.0
	N	A:PHE980	4.6	23.5	1.0
	CG	A:GLU1013	4.6	34.6	1.0
	N	A:GLU1132	4.7	33.9	1.0
	CD	A:GLU1132	4.8	41.1	1.0
	OE1	A:GLU1132	4.9	44.9	1.0
	C	A:PHE980	4.9	23.3	1.0
	O	A:ASP1129	4.9	28.9	1.0
	O	A:PHE980	5.0	24.0	1.0
	CA	A:GLU1132	5.0	35.2	1.0

Reference:

J.Wu, W.Li, B.P.Craddock, K.W.Foreman, M.J.Mulvihill, Q.S.Ji, W.T.Miller, S.R.Hubbard. Small-Molecule Inhibition and Activation-Loop Trans-Phosphorylation of the IGF1 Receptor Embo J. V. 27 1985 2008.
ISSN: ISSN 0261-4189
PubMed: 18566589
DOI: 10.1038/EMBOJ.2008.116

Page generated: Tue Jul 8 11:33:43 2025

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