Calcium in PDB 3fw0: Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate)

Enzymatic activity of Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate)

All present enzymatic activity of Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate):
4.3.2.5;

Protein crystallography data

The structure of Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate), PDB code: 3fw0 was solved by E.E.Chufan, M.De, B.A.Eipper, R.E.Mains, L.M.Amzel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	59.34 / 2.52
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	51.930, 75.080, 97.026, 90.00, 90.00, 90.00
*R / R_free (%)*	20.7 / 26

Other elements in 3fw0:

The structure of Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate) also contains other interesting chemical elements:

Mercury

(Hg)

2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate) (pdb code 3fw0). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate), PDB code: 3fw0:

Calcium binding site 1 out of 1 in 3fw0

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Calcium Binding Sites List in 3fw0

Calcium binding site 1 out of 1 in the Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate)

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase (Pal) Bound to Alpha-Hydroxyhippuric Acid (Non- Peptidic Substrate) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca823 b:42.6 occ:1.00	O	A:LEU587	2.5	44.5	1.0
	O	A:VAL520	2.5	43.3	1.0
	OD1	A:ASP787	2.6	46.2	1.0
	O	A:HOH108	2.6	31.3	1.0
	O	A:HOH107	2.6	34.2	1.0
	O	A:HOH109	3.0	34.2	1.0
	CG	A:ASP787	3.5	46.7	1.0
	C	A:LEU587	3.7	44.3	1.0
	C	A:VAL520	3.7	43.4	1.0
	OD2	A:ASP787	3.7	46.0	1.0
	N	A:VAL520	4.1	43.9	1.0
	CG2	A:VAL789	4.4	47.5	1.0
	CA	A:SER588	4.5	44.0	1.0
	N	A:SER588	4.5	44.0	1.0
	CA	A:VAL520	4.5	43.4	1.0
	CB	A:SER588	4.6	43.9	1.0
	CB	A:ALA521	4.6	43.6	1.0
	N	A:ALA521	4.6	43.8	1.0
	N	A:LEU587	4.6	44.9	1.0
	O	A:HOH34	4.6	27.4	1.0
	OD1	A:ASP638	4.7	49.5	1.0
	CA	A:LEU587	4.7	44.5	1.0
	CA	A:ALA521	4.7	43.9	1.0
	O	A:HOH81	4.8	37.7	1.0
	O	A:HOH56	4.8	29.7	1.0
	OD2	A:ASP638	4.9	48.0	1.0
	CB	A:ASP787	4.9	46.0	1.0
	O	A:ILE788	4.9	45.6	1.0
	CG2	A:VAL520	4.9	42.4	1.0

Reference:

E.E.Chufan, M.De, B.A.Eipper, R.E.Mains, L.M.Amzel. Amidation of Bioactive Peptides: the Structure of the Lyase Domain of the Amidating Enzyme. Structure V. 17 965 2009.
ISSN: ISSN 0969-2126
PubMed: 19604476
DOI: 10.1016/J.STR.2009.05.008

Page generated: Tue Jul 8 12:33:55 2025

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