Calcium in PDB 3gcx: PCSK9:Egfa (pH 7.4)

The structure of PCSK9:Egfa (pH 7.4), PDB code: 3gcx was solved by M.C.Mcnutt, H.J.Kwon, C.Chen, J.R.Chen, J.D.Horton, T.A.Lagace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.70
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	116.047, 116.047, 133.629, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 26.1

The binding sites of Calcium atom in the PCSK9:Egfa (pH 7.4) (pdb code 3gcx). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the PCSK9:Egfa (pH 7.4), PDB code: 3gcx:

Calcium binding site 1 out of 1 in the PCSK9:Egfa (pH 7.4)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of PCSK9:Egfa (pH 7.4) within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca1 b:58.1 occ:1.00 OD1 E:ASP310 2.3 56.7 1.0 O E:LEU311 2.4 56.2 1.0 O E:THR294 2.6 61.8 1.0 OE1 E:GLU296 2.8 60.8 1.0 O E:GLY314 2.9 56.5 1.0 O E:MET292 3.4 64.3 1.0 CG E:ASP310 3.4 56.5 1.0 OE2 E:GLU296 3.5 60.8 1.0 CD E:GLU296 3.5 60.8 1.0 C E:LEU311 3.6 56.2 1.0 C E:THR294 3.7 61.9 1.0 OD2 E:ASP310 3.9 56.6 1.0 O E:LYS312 4.0 55.9 1.0 C E:GLY314 4.0 56.5 1.0 N E:THR294 4.1 62.7 1.0 C E:LYS312 4.2 55.9 1.0 N E:GLY314 4.2 56.1 1.0 N E:LEU311 4.3 56.4 1.0 C E:ASP310 4.4 56.5 1.0 CA E:LYS312 4.5 55.8 1.0 N E:LYS312 4.5 56.0 1.0 CA E:GLY314 4.5 56.3 1.0 CA E:THR294 4.5 62.2 1.0 C E:MET292 4.5 64.2 1.0 N E:ASN295 4.6 61.5 1.0 CA E:LEU311 4.6 56.3 1.0 CB E:ASP310 4.6 56.5 1.0 CA E:ASP310 4.6 56.5 1.0 CA E:ASN295 4.7 61.1 1.0 N E:GLU296 4.8 60.4 1.0 C E:ILE313 4.9 56.0 1.0 N E:ILE313 4.9 55.9 1.0 O E:ASP310 4.9 56.5 1.0 C E:GLY293 4.9 63.1 1.0 CG E:GLU296 5.0 60.0 1.0

M.C.Mcnutt, H.J.Kwon, C.Chen, J.R.Chen, J.D.Horton, T.A.Lagace. Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HEPG2 Cells. J.Biol.Chem. V. 284 10561 2009.
ISSN: ISSN 0021-9258
PubMed: 19224862
DOI: 10.1074/JBC.M808802200