Calcium in PDB 4g28: Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1

The structure of Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1, PDB code: 4g28 was solved by M.Zhang, J.M.Pascal, J.-F.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	22.92 / 1.63
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	77.020, 66.670, 64.920, 90.00, 94.02, 90.00
R / Rfree (%)	19.2 / 22.7

The binding sites of Calcium atom in the Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1 (pdb code 4g28). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1, PDB code: 4g28:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1 within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1001 b:39.1 occ:1.00 O R:THR26 2.2 30.8 1.0 OD1 R:ASP24 2.3 35.2 1.0 OD1 R:ASP22 2.4 47.4 1.0 OD1 R:ASP20 2.4 38.1 1.0 OE1 R:GLU31 2.4 31.6 1.0 OE2 R:GLU31 2.5 34.6 1.0 O R:HOH1101 2.6 44.5 1.0 CD R:GLU31 2.7 42.1 1.0 CG R:ASP22 3.2 39.8 1.0 CG R:ASP24 3.3 45.3 1.0 H R:ASP24 3.3 58.5 1.0 HG22 R:THR26 3.4 62.2 1.0 H R:THR26 3.4 47.4 1.0 H R:ASP22 3.4 61.5 1.0 OD2 R:ASP22 3.5 54.3 1.0 C R:THR26 3.5 33.6 1.0 HA R:ASP20 3.6 44.0 1.0 CG R:ASP20 3.6 42.4 1.0 HG23 R:THR26 3.6 62.2 1.0 OD2 R:ASP24 3.9 42.1 1.0 HA R:ILE27 3.9 37.9 1.0 CG2 R:THR26 4.0 51.9 1.0 N R:ASP24 4.1 48.8 1.0 N R:THR26 4.1 39.5 1.0 HB3 R:ASP24 4.2 60.2 1.0 N R:ASP22 4.2 51.3 1.0 CG R:GLU31 4.2 34.9 1.0 CB R:ASP24 4.2 50.2 1.0 HG23 R:THR28 4.2 42.2 1.0 CA R:ASP20 4.3 36.7 1.0 H R:GLY23 4.3 63.5 1.0 CA R:THR26 4.3 32.8 1.0 H R:LYS21 4.3 54.2 1.0 CB R:ASP22 4.4 44.4 1.0 OD2 R:ASP20 4.4 39.6 1.0 C R:ASP20 4.4 50.3 1.0 HG3 R:GLU31 4.5 41.8 1.0 N R:ILE27 4.5 31.9 1.0 H R:THR28 4.5 36.7 1.0 CB R:ASP20 4.5 33.1 1.0 N R:GLY23 4.5 52.9 1.0 H R:GLY25 4.5 47.2 1.0 N R:LYS21 4.5 45.2 1.0 CA R:ASP24 4.6 52.2 1.0 HG2 R:GLU31 4.6 41.8 1.0 CA R:ILE27 4.6 31.6 1.0 CA R:ASP22 4.7 49.4 1.0 HG21 R:THR26 4.7 62.2 1.0 HB3 R:ASP22 4.7 53.2 1.0 C R:ASP22 4.7 52.5 1.0 N R:GLY25 4.8 39.4 1.0 CB R:THR26 4.8 49.8 1.0 C R:ASP24 4.8 46.7 1.0 O R:HOH1155 4.9 50.0 1.0 HB2 R:ASP20 4.9 39.7 1.0

Calcium binding site 2 out of 2 in the Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Small Conductance Potassium Channel Splice Variant and Ebio-1 within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1002 b:33.1 occ:1.00 O R:HOH1102 2.0 18.7 1.0 OD1 R:ASP56 2.1 38.4 1.0 OD2 R:ASP58 2.3 39.4 1.0 OE1 R:GLU67 2.5 39.5 1.0 OE2 R:GLU67 2.5 42.9 1.0 O R:THR62 2.6 33.2 1.0 OD1 R:ASN60 2.7 42.8 1.0 CD R:GLU67 2.9 41.6 1.0 HA R:ASP56 3.0 60.4 1.0 H R:ASP58 3.1 73.5 1.0 CG R:ASP56 3.3 33.2 1.0 H R:ASN60 3.4 48.4 1.0 CG R:ASP58 3.5 42.4 1.0 H R:GLY59 3.6 62.1 1.0 CA R:ASP56 3.7 50.4 1.0 CG R:ASN60 3.7 53.3 1.0 H R:THR62 3.8 39.2 1.0 C R:THR62 3.8 36.9 1.0 HA R:ILE63 3.8 37.4 1.0 C R:ASP56 3.9 60.5 1.0 H R:ALA57 3.9 73.4 1.0 N R:ASP58 3.9 61.3 1.0 CB R:ASP56 3.9 33.4 1.0 O R:HOH1256 4.0 38.5 1.0 N R:ALA57 4.0 61.2 1.0 OD1 R:ASP58 4.1 44.4 1.0 O R:HOH1237 4.1 42.1 1.0 HB2 R:ASP56 4.1 40.1 1.0 N R:GLY59 4.1 51.8 1.0 N R:ASN60 4.1 40.4 1.0 OD2 R:ASP56 4.2 41.2 1.0 H R:ASP64 4.2 46.0 1.0 H R:GLY61 4.2 42.2 1.0 HD22 R:ASN60 4.3 63.5 1.0 CG R:GLU67 4.4 39.2 1.0 N R:THR62 4.4 32.7 1.0 ND2 R:ASN60 4.4 53.0 1.0 O R:ASP56 4.5 61.9 1.0 CA R:ASP58 4.6 50.3 1.0 CB R:ASP58 4.6 46.3 1.0 CA R:ILE63 4.6 31.2 1.0 C R:ASP58 4.6 49.9 1.0 N R:ILE63 4.7 32.2 1.0 N R:GLY61 4.7 35.2 1.0 CB R:ASN60 4.7 50.9 1.0 CA R:THR62 4.7 34.5 1.0 HG2 R:GLU67 4.8 47.0 1.0 HG3 R:GLU67 4.8 47.0 1.0 CA R:ASN60 4.8 40.4 1.0 HB3 R:ALA57 4.8 77.0 1.0 HB3 R:ASP56 4.8 40.1 1.0 HB3 R:ASN60 4.8 61.0 1.0 C R:ALA57 4.8 59.5 1.0 N R:ASP64 4.9 38.4 1.0 CA R:ALA57 4.9 58.1 1.0 CA R:GLY59 5.0 46.9 1.0 HA2 R:GLY59 5.0 56.3 1.0

M.Zhang, J.M.Pascal, M.Schumann, R.S.Armen, J.F.Zhang. Identification of the Functional Binding Pocket For Compounds Targeting Small-Conductance Ca(2+)-Activated Potassium Channels. Nat Commun V. 3 1021 2012.
ISSN: ESSN 2041-1723
PubMed: 22929778
DOI: 10.1038/NCOMMS2017