Calcium in PDB 4mtf: Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel

The structure of Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mtf was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.90 / 3.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.745, 177.790, 131.105, 90.00, 132.69, 90.00
R / Rfree (%)	24.1 / 27.2

The binding sites of Calcium atom in the Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mtf). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mtf:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1301 b:0.7 occ:1.00 OD1 B:ASP1177 4.1 56.5 1.0 OD1 A:ASP1177 4.2 66.5 1.0 OD1 C:ASP1177 4.3 53.9 1.0 N B:ASP1178 4.4 72.5 1.0 O A:LEU1176 4.4 56.6 1.0 N A:ASP1178 4.4 72.2 1.0 OD1 D:ASP1177 4.4 73.5 1.0 N C:ASP1178 4.5 65.0 1.0 CA C:CA1301 4.5 66.4 1.0 O B:LEU1176 4.6 47.3 1.0 N D:ASP1178 4.6 67.2 1.0 CA B:ASP1177 4.7 71.0 1.0 CA A:ASP1177 4.8 77.1 1.0 O C:LEU1176 4.9 46.6 1.0 CA D:ASP1177 4.9 73.7 1.0 CA C:ASP1177 4.9 71.0 1.0 O D:LEU1176 5.0 53.9 1.0

Calcium binding site 2 out of 2 in the Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural Basis of CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1301 b:66.4 occ:1.00 OD1 B:ASP1178 4.0 76.8 1.0 CG B:ASP1178 4.0 81.1 1.0 CG D:ASP1178 4.1 77.3 1.0 CB D:ASP1178 4.1 80.7 1.0 CB C:ASP1178 4.1 77.3 1.0 OD1 D:ASP1178 4.2 60.3 1.0 CG A:ASP1178 4.2 75.1 1.0 CG C:ASP1178 4.2 76.6 1.0 CB B:ASP1178 4.2 81.1 1.0 OD1 C:ASP1178 4.3 57.6 1.0 CB A:ASP1178 4.3 80.5 1.0 OD1 A:ASP1178 4.4 71.4 1.0 OD2 B:ASP1178 4.4 85.4 1.0 CA A:CA1301 4.5 0.7 1.0 OD2 A:ASP1178 4.5 80.4 1.0 OD2 D:ASP1178 4.5 88.0 1.0 CA D:ASP1178 4.6 69.9 1.0 CA B:ASP1178 4.6 73.4 1.0 CA C:ASP1178 4.7 73.3 1.0 OD2 C:ASP1178 4.7 94.9 1.0 CA A:ASP1178 4.8 79.3 1.0 OD1 C:ASP1177 4.9 53.9 1.0 N D:ASP1178 4.9 67.2 1.0

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775