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Atomistry » Calcium » PDB 4zmq-5a3y » 4zxy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 4zmq-5a3y » 4zxy » |
Calcium in PDB 4zxy: Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-DioneEnzymatic activity of Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione
All present enzymatic activity of Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione:
3.4.21.21; Protein crystallography data
The structure of Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione, PDB code: 4zxy
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione
(pdb code 4zxy). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione, PDB code: 4zxy: Calcium binding site 1 out of 1 in 4zxyGo back to![]() ![]()
Calcium binding site 1 out
of 1 in the Factor Viia in Complex with the Inhibitor (2R)-2-[(1-Aminoisoquinolin- 6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7, 9,16,19-Hexaene-3,12-Dione
![]() Mono view ![]() Stereo pair view
Reference:
E.S.Priestley,
D.L.Cheney,
I.Delucca,
A.Wei,
J.M.Luettgen,
A.R.Rendina,
P.C.Wong,
R.R.Wexler.
Structure-Based Design of Macrocyclic Coagulation Factor Viia Inhibitors. J.Med.Chem. V. 58 6225 2015.
Page generated: Sun Jul 14 16:11:58 2024
ISSN: ISSN 0022-2623 PubMed: 26151189 DOI: 10.1021/ACS.JMEDCHEM.5B00788 |
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