Calcium in PDB 5fae: N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form)

The structure of N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form), PDB code: 5fae was solved by F.Boni, M.Milani, S.Ricagno, M.Bolognesi, M.De Rosa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.63 / 1.70
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	46.919, 46.919, 84.623, 90.00, 90.00, 120.00
R / Rfree (%)	18.2 / 22.5

The structure of N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form) also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Calcium atom in the N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form) (pdb code 5fae). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form), PDB code: 5fae:

Calcium binding site 1 out of 1 in the N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of N184K Pathological Variant of Gelsolin Domain 2 (Trigonal Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca301 b:29.8 occ:1.00 O A:GLY186 2.2 27.0 1.0 O A:HOH433 2.3 29.0 1.0 O A:HOH453 2.3 41.0 1.0 OE2 A:GLU209 2.3 28.9 1.0 O A:HOH402 2.5 36.0 1.0 OD1 A:ASP187 2.5 26.8 1.0 OE1 A:GLU209 2.6 27.8 1.0 CD A:GLU209 2.8 27.2 1.0 C A:GLY186 3.3 25.7 1.0 CG A:ASP187 3.6 27.5 1.0 CA A:ASP187 4.0 23.0 1.0 O1 A:SO4305 4.0 79.4 1.0 N A:ASP187 4.0 23.5 1.0 CA A:GLY186 4.2 28.2 1.0 CG A:GLU209 4.3 24.2 1.0 CB A:ASP187 4.4 21.6 1.0 ND2 A:ASN206 4.4 29.9 1.0 O A:HOH437 4.4 53.6 1.0 NZ A:LYS166 4.5 55.7 1.0 CG A:LYS166 4.6 31.3 1.0 OD2 A:ASP187 4.6 28.8 1.0 CA A:SER205 4.6 28.5 1.0 O A:ASN204 4.7 30.8 1.0 N A:GLY167 4.7 29.9 1.0 O3 A:SO4305 4.8 78.3 1.0 N A:ASN206 4.8 33.4 1.0 S A:SO4305 4.9 76.4 1.0

F.Boni, M.Milani, R.Porcari, A.Barbiroli, S.Ricagno, M.De Rosa. Molecular Basis of A Novel Renal Amyloidosis Due to N184K Gelsolin Variant. Sci Rep V. 6 33463 2016.
ISSN: ESSN 2045-2322
PubMed: 27633054
DOI: 10.1038/SREP33463