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Calcium in PDB 5hi6: The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form

Enzymatic activity of The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form

All present enzymatic activity of The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form:
1.5.1.3;

Protein crystallography data

The structure of The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form, PDB code: 5hi6 was solved by C.Chang, N.Maltseva, Y.Kim, M.Makowska-Grzyska, R.Mulligan, L.Papazisi, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.69 / 2.05
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 44.151, 60.623, 109.942, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 22.3

Other elements in 5hi6:

The structure of The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form also contains other interesting chemical elements:

Potassium (K) 2 atoms
Chlorine (Cl) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form (pdb code 5hi6). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form, PDB code: 5hi6:

Calcium binding site 1 out of 1 in 5hi6

Go back to Calcium Binding Sites List in 5hi6
Calcium binding site 1 out of 1 in the The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca202

b:52.5
occ:1.00
 O A:HOH426 2.3 36.4 1.0
O A:MSE17 2.3 28.4 1.0
O A:HOH429 2.4 30.9 1.0
O A:HOH318 2.8 35.1 1.0
O A:HOH353 2.8 28.6 1.0
O A:HOH371 3.0 44.3 1.0
C A:MSE17 3.5 22.5 1.0
O A:GLU18 3.7 28.2 1.0
N A:MSE17 3.9 25.3 1.0
C A:GLU18 4.1 30.5 1.0
O A:ASN19 4.3 16.1 1.0
CA A:MSE17 4.4 30.1 1.0
O A:HOH366 4.4 37.8 1.0
N A:GLU18 4.5 32.7 1.0
CA A:GLU18 4.5 31.5 1.0
O A:HOH320 4.6 29.6 1.0
C A:GLY16 4.7 26.8 1.0
CA A:GLY16 4.7 18.0 1.0
N A:ASN19 4.8 17.6 1.0
C A:ASN19 4.9 21.1 1.0

Reference:

C.Chang, N.Maltseva, Y.Kim, M.Makowska-Grzyska, R.Mulligan, L.Papazisi, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). The High Resolution Structure of Dihydrofolate Reductase From Yersinia Pestis Complex with Methotrexate As Closed Form To Be Published.
Page generated: Wed Jul 9 06:27:17 2025

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