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Calcium in PDB 5m0m: Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors
Enzymatic activity of Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors
All present enzymatic activity of Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors, PDB code: 5m0m
was solved by
W.-J.Keune,
T.Heidebrecht,
A.Perrakis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 75.27 / 2.10 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 62.995, 89.173, 77.289, 90.00, 103.12, 90.00 |
| R / Rfree (%) | 20.1 / 24.9 |
Other elements in 5m0m:
The structure of Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Iodine | (I) | 12 atoms |
| Chlorine | (Cl) | 2 atoms |
| Sodium | (Na) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors
(pdb code 5m0m). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors, PDB code: 5m0m:
In total only one binding site of Calcium was determined in the Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors, PDB code: 5m0m:
Calcium binding site 1 out of 1 in 5m0m
Go back to
Calcium Binding Sites List in 5m0m
Calcium binding site 1 out
of 1 in the Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Structure-Based Evolution of A Hybrid Steroid Series of Autotaxin Inhibitors within 5.0Å range:
|
Reference:
W.J.Keune,
F.Potjewyd,
T.Heidebrecht,
F.Salgado-Polo,
S.J.Macdonald,
L.Chelvarajan,
A.Abdel Latif,
S.Soman,
A.J.Morris,
A.J.Watson,
C.Jamieson,
A.Perrakis.
Rational Design of Autotaxin Inhibitors By Structural Evolution of Endogenous Modulators. J. Med. Chem. V. 60 2006 2017.
ISSN: ISSN 1520-4804
PubMed: 28165241
DOI: 10.1021/ACS.JMEDCHEM.6B01743
Page generated: Wed Jul 9 08:03:13 2025
ISSN: ISSN 1520-4804
PubMed: 28165241
DOI: 10.1021/ACS.JMEDCHEM.6B01743
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