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Calcium in PDB 6ob0: Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells

Enzymatic activity of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells

All present enzymatic activity of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells:
3.1.1.34;

Protein crystallography data

The structure of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells, PDB code: 6ob0 was solved by R.Arora, P.A.Horton, T.E.Benson, M.J.Romanowski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.15 / 2.81
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 153.430, 191.420, 97.180, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 23.3

Calcium Binding Sites:

The binding sites of Calcium atom in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells (pdb code 6ob0). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells, PDB code: 6ob0:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in 6ob0

Go back to Calcium Binding Sites List in 6ob0
Calcium binding site 1 out of 4 in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca507

b:62.1
occ:1.00
 O A:HOH615 2.2 83.0 1.0
O A:ALA194 2.2 61.4 1.0
OG A:SER199 2.4 52.3 1.0
OD2 A:ASP202 2.4 68.9 1.0
OD1 A:ASP202 2.4 70.8 1.0
O A:ARG197 2.5 50.0 1.0
O A:HOH624 2.6 52.5 1.0
CG A:ASP202 2.8 67.0 1.0
C A:ALA194 3.3 62.2 1.0
CB A:SER199 3.7 50.9 1.0
C A:ARG197 3.7 53.3 1.0
N A:SER199 3.7 46.4 1.0
CA A:PRO195 4.0 58.4 1.0
N A:PRO195 4.1 58.6 1.0
C A:LEU198 4.2 50.1 1.0
CA A:ALA194 4.2 59.9 1.0
CA A:SER199 4.3 47.0 1.0
CB A:ASP202 4.3 55.4 1.0
O A:GLY166 4.3 49.8 1.0
C A:PRO195 4.3 64.0 1.0
CA A:LEU198 4.3 46.8 1.0
OD2 A:ASP201 4.4 94.7 1.0
OD1 A:ASP201 4.4 81.8 1.0
N A:LEU198 4.5 48.1 1.0
O A:PRO195 4.5 64.4 1.0
C A:GLY166 4.5 52.5 1.0
CB A:SER170 4.6 54.7 1.0
CB A:ALA194 4.6 60.7 1.0
N A:ARG197 4.6 52.5 1.0
CG A:ASP201 4.7 81.7 1.0
OG A:SER170 4.8 66.7 1.0
O A:SER199 4.8 49.0 1.0
CA A:ARG197 4.8 51.7 1.0
O A:LEU198 4.9 50.1 1.0
C A:SER199 4.9 51.6 1.0
N A:SER196 4.9 59.1 1.0
CA A:GLY166 4.9 53.5 1.0

Calcium binding site 2 out of 4 in 6ob0

Go back to Calcium Binding Sites List in 6ob0
Calcium binding site 2 out of 4 in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca508

b:57.9
occ:1.00
 O B:ALA194 2.2 68.9 1.0
OG B:SER199 2.2 77.3 1.0
OD2 B:ASP202 2.3 77.3 1.0
O B:HOH608 2.3 72.9 1.0
O B:ARG197 2.4 56.5 1.0
O B:HOH625 2.5 40.9 1.0
OD1 B:ASP202 2.5 66.3 1.0
CG B:ASP202 2.7 66.2 1.0
C B:ALA194 3.3 69.3 1.0
CB B:SER199 3.5 63.1 1.0
N B:SER199 3.5 55.8 1.0
C B:ARG197 3.7 56.9 1.0
C B:LEU198 4.0 59.1 1.0
CA B:SER199 4.1 56.1 1.0
CA B:PRO195 4.1 66.7 1.0
N B:PRO195 4.2 67.1 1.0
CA B:LEU198 4.2 52.2 1.0
CA B:ALA194 4.2 64.8 1.0
CB B:ASP202 4.3 55.3 1.0
OD1 B:ASP201 4.3 75.5 1.0
O B:GLY166 4.4 58.6 1.0
N B:LEU198 4.4 51.7 1.0
C B:PRO195 4.4 68.1 1.0
OD2 B:ASP201 4.4 81.9 1.0
CB B:ALA194 4.5 65.2 1.0
C B:GLY166 4.6 57.7 1.0
O B:PRO195 4.6 68.1 1.0
N B:ARG197 4.6 57.2 1.0
O B:SER199 4.6 60.4 1.0
O B:LEU198 4.7 59.8 1.0
CB B:SER170 4.7 57.5 1.0
CG B:ASP201 4.7 74.3 1.0
C B:SER199 4.8 59.3 1.0
CA B:ARG197 4.8 55.6 1.0
OG B:SER170 4.9 78.4 1.0
CA B:GLY166 4.9 53.0 1.0
N B:SER196 5.0 62.6 1.0

Calcium binding site 3 out of 4 in 6ob0

Go back to Calcium Binding Sites List in 6ob0
Calcium binding site 3 out of 4 in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca507

b:60.4
occ:1.00
 OD2 C:ASP202 2.3 76.9 1.0
O C:HOH619 2.3 64.6 1.0
O C:ALA194 2.3 62.0 1.0
OG C:SER199 2.4 60.7 1.0
OD1 C:ASP202 2.4 73.1 1.0
O C:ARG197 2.5 55.1 1.0
O C:HOH622 2.6 44.3 1.0
CG C:ASP202 2.7 70.5 1.0
C C:ALA194 3.4 62.2 1.0
N C:SER199 3.6 50.1 1.0
CB C:SER199 3.6 53.0 1.0
C C:ARG197 3.7 54.4 1.0
C C:LEU198 4.1 52.1 1.0
CA C:PRO195 4.1 56.9 1.0
CB C:ASP202 4.2 55.2 1.0
CA C:LEU198 4.2 47.4 1.0
CA C:SER199 4.2 50.5 1.0
O C:GLY166 4.2 49.0 1.0
N C:PRO195 4.2 57.9 1.0
CA C:ALA194 4.3 59.0 1.0
C C:PRO195 4.4 59.8 1.0
N C:LEU198 4.4 48.8 1.0
OD1 C:ASP201 4.4 80.6 1.0
OD2 C:ASP201 4.4 86.4 1.0
C C:GLY166 4.4 49.2 1.0
O C:PRO195 4.5 57.5 1.0
CB C:SER170 4.6 53.1 1.0
N C:ARG197 4.6 53.6 1.0
CB C:ALA194 4.7 59.2 1.0
O C:SER199 4.7 56.5 1.0
CG C:ASP201 4.8 77.2 1.0
CA C:ARG197 4.8 51.6 1.0
OG C:SER170 4.8 57.3 1.0
CA C:GLY166 4.8 45.2 1.0
O C:LEU198 4.8 51.4 1.0
C C:SER199 4.8 56.6 1.0
N C:SER196 5.0 56.7 1.0

Calcium binding site 4 out of 4 in 6ob0

Go back to Calcium Binding Sites List in 6ob0
Calcium binding site 4 out of 4 in the Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Compound 2 Bound Structure of Wt Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D Produced in HEK293-F Cells within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ca507

b:52.7
occ:1.00
 O D:HOH643 2.1 42.7 1.0
O D:ALA194 2.2 68.3 1.0
OG D:SER199 2.4 60.1 1.0
OD1 D:ASP202 2.4 71.9 1.0
OD2 D:ASP202 2.4 70.2 1.0
O D:HOH604 2.5 54.1 1.0
O D:ARG197 2.6 50.9 1.0
CG D:ASP202 2.7 69.2 1.0
C D:ALA194 3.3 67.4 1.0
CB D:SER199 3.6 55.7 1.0
N D:SER199 3.8 51.8 1.0
C D:ARG197 3.8 52.3 1.0
CA D:PRO195 4.0 61.8 1.0
N D:PRO195 4.0 62.6 1.0
CA D:ALA194 4.2 62.8 1.0
C D:LEU198 4.2 54.2 1.0
CA D:SER199 4.3 52.0 1.0
CB D:ASP202 4.3 57.1 1.0
OD1 D:ASP201 4.3 77.0 1.0
C D:PRO195 4.3 61.7 1.0
OD2 D:ASP201 4.3 83.0 1.0
O D:GLY166 4.3 54.8 1.0
CA D:LEU198 4.4 45.1 1.0
O D:PRO195 4.5 60.5 1.0
CB D:SER170 4.5 57.0 1.0
CB D:ALA194 4.5 63.3 1.0
N D:LEU198 4.6 46.7 1.0
C D:GLY166 4.6 55.2 1.0
CG D:ASP201 4.6 75.8 1.0
N D:ARG197 4.7 54.0 1.0
OG D:SER170 4.7 78.8 1.0
O D:SER199 4.7 58.7 1.0
C D:SER199 4.9 58.4 1.0
N D:SER196 4.9 56.5 1.0
CA D:ARG197 4.9 51.9 1.0
O D:LEU198 5.0 55.6 1.0

Reference:

R.Arora, A.V.Nimonkar, D.Baird, C.Wang, C.H.Chiu, P.A.Horton, S.Hanrahan, R.Cubbon, S.Weldon, W.R.Tschantz, S.Mueller, R.Brunner, P.Lehr, P.Meier, J.Ottl, A.Voznesensky, P.Pandey, T.M.Smith, A.Stojanovic, A.Flyer, T.E.Benson, M.J.Romanowski, J.W.Trauger. Structure of Lipoprotein Lipase in Complex with GPIHBP1. Proc.Natl.Acad.Sci.Usa V. 116 10360 2019.
ISSN: ESSN 1091-6490
PubMed: 31072929
DOI: 10.1073/PNAS.1820171116
Page generated: Wed Jul 9 16:28:52 2025

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