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Atomistry » Calcium » PDB 6p8x-6pu4 » 6p8z | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 6p8x-6pu4 » 6p8z » |
Calcium in PDB 6p8z: Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide InhibitorProtein crystallography data
The structure of Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor, PDB code: 6p8z
was solved by
C.Mohr,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6p8z:
The structure of Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
(pdb code 6p8z). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor, PDB code: 6p8z: Jump to Calcium binding site number: 1; 2; 3; 4; Calcium binding site 1 out of 4 in 6p8zGo back to![]() ![]()
Calcium binding site 1 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
![]() Mono view ![]() Stereo pair view
Calcium binding site 2 out of 4 in 6p8zGo back to![]() ![]()
Calcium binding site 2 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
![]() Mono view ![]() Stereo pair view
Calcium binding site 3 out of 4 in 6p8zGo back to![]() ![]()
Calcium binding site 3 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
![]() Mono view ![]() Stereo pair view
Calcium binding site 4 out of 4 in 6p8zGo back to![]() ![]()
Calcium binding site 4 out
of 4 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
Y.Shin,
J.W.Jeong,
R.P.Wurz,
P.Achanta,
T.Arvedson,
M.D.Bartberger,
I.D.G.Campuzano,
R.Fucini,
S.K.Hansen,
J.Ingersoll,
J.S.Iwig,
J.R.Lipford,
V.Ma,
D.J.Kopecky,
J.Mccarter,
T.San Miguel,
C.Mohr,
S.Sabet,
A.Y.Saiki,
A.Sawayama,
S.Sethofer,
C.M.Tegley,
L.P.Volak,
K.Yang,
B.A.Lanman,
D.A.Erlanson,
V.J.Cee.
Discovery Ofn-(1-Acryloylazetidin-3-Yl)-2-(1H-Indol-1-Yl) Acetamides As Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett. V. 10 1302 2019.
Page generated: Tue Jul 16 12:49:01 2024
ISSN: ISSN 1948-5875 PubMed: 31531201 DOI: 10.1021/ACSMEDCHEMLETT.9B00258 |
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