Calcium in PDB 7b5e: Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution

The binding sites of Calcium atom in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution (pdb code 7b5e). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution, PDB code: 7b5e:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1001 b:43.1 occ:1.00 OD1 A:ASN651 2.5 52.4 1.0 OD1 A:ASN650 2.5 50.9 1.0 N A:ASN651 2.7 52.4 1.0 C A:ASN650 2.8 50.9 1.0 CB A:ASN650 2.9 50.9 1.0 OE2 A:GLU705 3.0 32.0 1.0 CG A:ASN650 3.0 50.9 1.0 CA A:ASN651 3.2 52.4 1.0 CG A:ASN651 3.3 52.4 1.0 O A:ASN650 3.3 50.9 1.0 CA A:ASN650 3.4 50.9 1.0 CA A:CA1002 3.6 41.5 1.0 O A:GLN646 3.6 46.5 1.0 OE1 A:GLU734 3.7 31.3 1.0 CD A:GLU705 3.8 32.0 1.0 CB A:ASN651 3.8 52.4 1.0 OE1 A:GLU705 4.0 32.0 1.0 ND2 A:ASN651 4.2 52.4 1.0 N A:ASN650 4.3 50.9 1.0 ND2 A:ASN650 4.4 50.9 1.0 OE2 A:GLU734 4.4 31.3 1.0 CD A:GLU734 4.5 31.3 1.0 C A:ASN651 4.6 52.4 1.0 OD1 A:ASN730 4.6 30.9 1.0 C A:GLN646 4.7 46.5 1.0 CG A:GLU705 5.0 32.0 1.0

Calcium binding site 2 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:41.5 occ:1.00 OE2 A:GLU734 2.5 31.3 1.0 OE1 A:GLU705 2.5 32.0 1.0 OE2 A:GLU654 2.5 60.6 1.0 OE2 A:GLU702 2.5 33.0 1.0 OE1 A:GLU654 2.7 60.6 1.0 CD A:GLU654 2.7 60.6 1.0 OE2 A:GLU705 3.1 32.0 1.0 CD A:GLU705 3.1 32.0 1.0 CD A:GLU734 3.4 31.3 1.0 OD1 A:ASN650 3.5 50.9 1.0 CD A:GLU702 3.6 33.0 1.0 CA A:CA1001 3.6 43.1 1.0 OE1 A:GLU734 3.7 31.3 1.0 CG A:GLU654 3.9 60.6 1.0 OE1 A:GLU702 4.1 33.0 1.0 OD2 A:ASP738 4.2 36.4 1.0 CB A:GLU654 4.2 60.6 1.0 OD1 A:ASP738 4.3 36.4 1.0 CG A:GLU705 4.6 32.0 1.0 CG A:ASP738 4.7 36.4 1.0 CG A:ASN650 4.7 50.9 1.0 OD1 A:ASN651 4.8 52.4 1.0 CG A:GLU734 4.8 31.3 1.0 CG A:GLU702 4.9 33.0 1.0 O A:ASN650 5.0 50.9 1.0

Calcium binding site 3 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1001 b:40.1 occ:1.00 OD1 B:ASN651 2.5 47.6 1.0 OD1 B:ASN650 2.5 47.5 1.0 N B:ASN651 2.7 47.6 1.0 C B:ASN650 2.8 47.5 1.0 CB B:ASN650 2.9 47.5 1.0 OE2 B:GLU705 3.0 32.2 1.0 CG B:ASN650 3.0 47.5 1.0 CA B:ASN651 3.2 47.6 1.0 CG B:ASN651 3.3 47.6 1.0 O B:ASN650 3.3 47.5 1.0 CA B:ASN650 3.4 47.5 1.0 CA B:CA1002 3.6 38.8 1.0 O B:GLN646 3.6 43.9 1.0 OE1 B:GLU734 3.7 30.0 1.0 CD B:GLU705 3.8 32.2 1.0 CB B:ASN651 3.8 47.6 1.0 OE1 B:GLU705 4.0 32.2 1.0 ND2 B:ASN651 4.2 47.6 1.0 N B:ASN650 4.3 47.5 1.0 ND2 B:ASN650 4.4 47.5 1.0 OE2 B:GLU734 4.4 30.0 1.0 CD B:GLU734 4.5 30.0 1.0 C B:ASN651 4.6 47.6 1.0 OD1 B:ASN730 4.6 29.1 1.0 C B:GLN646 4.7 43.9 1.0 CG B:GLU705 5.0 32.2 1.0

Calcium binding site 4 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Calcium-Bound MTMEM16A(Ac)-I551A Chloride Channel at 4.1 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:38.8 occ:1.00 OE2 B:GLU734 2.5 30.0 1.0 OE1 B:GLU705 2.5 32.2 1.0 OE2 B:GLU654 2.5 56.7 1.0 OE2 B:GLU702 2.5 33.0 1.0 OE1 B:GLU654 2.6 56.7 1.0 CD B:GLU654 2.7 56.7 1.0 OE2 B:GLU705 3.1 32.2 1.0 CD B:GLU705 3.1 32.2 1.0 CD B:GLU734 3.4 30.0 1.0 OD1 B:ASN650 3.5 47.5 1.0 CA B:CA1001 3.6 40.1 1.0 CD B:GLU702 3.6 33.0 1.0 OE1 B:GLU734 3.7 30.0 1.0 CG B:GLU654 3.9 56.7 1.0 OE1 B:GLU702 4.1 33.0 1.0 OD2 B:ASP738 4.2 34.6 1.0 CB B:GLU654 4.2 56.7 1.0 OD1 B:ASP738 4.3 34.6 1.0 CG B:GLU705 4.6 32.2 1.0 CG B:ASP738 4.7 34.6 1.0 CG B:ASN650 4.7 47.5 1.0 OD1 B:ASN651 4.8 47.6 1.0 CG B:GLU734 4.8 30.0 1.0 CG B:GLU702 4.9 33.0 1.0 O B:ASN650 5.0 47.5 1.0

A.K.M.Lam, J.Rheinberger, C.Paulino, R.Dutzler. Gating the Pore of the Calcium-Activated Chloride Channel TMEM16A Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-020-20787-9