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Calcium in PDB 7dxg: Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom

Other elements in 7dxg:

The structure of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Zinc (Zn) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom (pdb code 7dxg). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom, PDB code: 7dxg:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in 7dxg

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Calcium binding site 1 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1002

b:98.7
occ:1.00
O A:GLU144 2.5 94.3 1.0
OD1 A:ASP890 2.5 121.4 1.0
OE1 A:GLU144 2.7 142.8 1.0
CD A:GLU144 3.6 113.1 1.0
CG A:ASP890 3.7 109.9 1.0
C A:GLU144 3.7 82.2 1.0
OE2 A:GLU144 4.1 113.5 1.0
OD2 A:ASP890 4.3 114.1 1.0
CA A:HIS145 4.3 81.2 1.0
N A:LEU146 4.5 91.2 1.0
N A:HIS145 4.5 78.0 1.0
CB A:GLU144 4.6 83.5 1.0
CA A:ASP890 4.7 83.7 1.0
CG A:GLU144 4.7 97.6 1.0
ND1 A:HIS145 4.7 79.6 1.0
CB A:ASP890 4.8 90.8 1.0
CA A:GLU144 4.8 79.9 1.0
OE1 A:GLU147 4.8 111.5 1.0
NZ D:LYS888 4.8 104.2 1.0
C A:HIS145 5.0 87.4 1.0

Calcium binding site 2 out of 8 in 7dxg

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Calcium binding site 2 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1005

b:127.2
occ:1.00
OE1 A:GLU883 2.5 113.5 1.0
OE1 D:GLU881 2.9 129.6 1.0
OE2 A:GLU883 3.2 125.4 1.0
O A:GLU878 3.2 104.5 1.0
CD A:GLU883 3.2 115.9 1.0
CD D:GLU881 3.8 124.1 1.0
CG D:GLU881 3.8 110.5 1.0
ND2 A:ASN880 3.9 104.6 1.0
CG A:ASN880 4.0 100.7 1.0
OD1 A:ASN880 4.1 103.9 1.0
C A:GLU878 4.2 101.6 1.0
N A:ASN880 4.4 105.3 1.0
CA A:VAL879 4.5 95.5 1.0
CB D:GLU881 4.5 101.3 1.0
CB A:ASP877 4.5 113.4 1.0
CG A:GLU883 4.7 106.8 1.0
CB A:ASN880 4.7 99.7 1.0
C A:VAL879 4.8 101.0 1.0
N A:VAL879 4.8 100.1 1.0
O A:ASP877 4.9 111.3 1.0
C A:ASP877 5.0 108.7 1.0
OE2 D:GLU881 5.0 126.9 1.0

Calcium binding site 3 out of 8 in 7dxg

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Calcium binding site 3 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1002

b:98.7
occ:1.00
O B:GLU144 2.5 94.3 1.0
OD1 B:ASP890 2.5 121.4 1.0
OE1 B:GLU144 2.7 142.8 1.0
CD B:GLU144 3.6 113.1 1.0
CG B:ASP890 3.7 109.9 1.0
C B:GLU144 3.7 82.2 1.0
OE2 B:GLU144 4.1 113.5 1.0
OD2 B:ASP890 4.3 114.1 1.0
CA B:HIS145 4.3 81.2 1.0
N B:LEU146 4.5 91.2 1.0
N B:HIS145 4.5 78.0 1.0
CB B:GLU144 4.6 83.5 1.0
CA B:ASP890 4.7 83.7 1.0
CG B:GLU144 4.7 97.6 1.0
ND1 B:HIS145 4.7 79.6 1.0
CB B:ASP890 4.8 90.8 1.0
CA B:GLU144 4.8 79.9 1.0
OE1 B:GLU147 4.8 111.5 1.0
NZ C:LYS888 4.8 104.2 1.0
C B:HIS145 5.0 87.4 1.0

Calcium binding site 4 out of 8 in 7dxg

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Calcium binding site 4 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1005

b:127.2
occ:1.00
OE1 B:GLU883 2.5 113.5 1.0
OE1 C:GLU881 2.9 129.6 1.0
OE2 B:GLU883 3.2 125.4 1.0
O B:GLU878 3.2 104.5 1.0
CD B:GLU883 3.2 115.9 1.0
CD C:GLU881 3.8 124.1 1.0
CG C:GLU881 3.8 110.5 1.0
ND2 B:ASN880 3.9 104.6 1.0
CG B:ASN880 4.0 100.7 1.0
OD1 B:ASN880 4.1 103.9 1.0
C B:GLU878 4.2 101.6 1.0
N B:ASN880 4.4 105.3 1.0
CA B:VAL879 4.5 95.5 1.0
CB C:GLU881 4.5 101.3 1.0
CB B:ASP877 4.5 113.4 1.0
CG B:GLU883 4.7 106.8 1.0
CB B:ASN880 4.7 99.7 1.0
C B:VAL879 4.8 101.0 1.0
N B:VAL879 4.8 100.1 1.0
O B:ASP877 4.9 111.3 1.0
C B:ASP877 5.0 108.7 1.0
OE2 C:GLU881 5.0 126.9 1.0

Calcium binding site 5 out of 8 in 7dxg

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Calcium binding site 5 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1003

b:98.7
occ:1.00
O C:GLU144 2.5 94.3 1.0
OD1 C:ASP890 2.5 121.4 1.0
OE1 C:GLU144 2.7 142.8 1.0
CD C:GLU144 3.6 113.1 1.0
CG C:ASP890 3.7 109.9 1.0
C C:GLU144 3.7 82.2 1.0
OE2 C:GLU144 4.1 113.5 1.0
OD2 C:ASP890 4.3 114.1 1.0
CA C:HIS145 4.3 81.2 1.0
N C:LEU146 4.5 91.2 1.0
N C:HIS145 4.5 78.0 1.0
CB C:GLU144 4.6 83.5 1.0
CA C:ASP890 4.7 83.7 1.0
CG C:GLU144 4.7 97.6 1.0
ND1 C:HIS145 4.7 79.6 1.0
CB C:ASP890 4.8 90.8 1.0
CA C:GLU144 4.8 79.9 1.0
OE1 C:GLU147 4.8 111.5 1.0
NZ A:LYS888 4.8 104.2 1.0
C C:HIS145 5.0 87.4 1.0

Calcium binding site 6 out of 8 in 7dxg

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Calcium binding site 6 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1006

b:127.2
occ:1.00
OE1 C:GLU883 2.5 113.5 1.0
OE1 A:GLU881 2.9 129.6 1.0
OE2 C:GLU883 3.2 125.4 1.0
O C:GLU878 3.2 104.5 1.0
CD C:GLU883 3.2 115.9 1.0
CD A:GLU881 3.8 124.1 1.0
CG A:GLU881 3.8 110.5 1.0
ND2 C:ASN880 3.9 104.6 1.0
CG C:ASN880 4.0 100.7 1.0
OD1 C:ASN880 4.1 103.9 1.0
C C:GLU878 4.2 101.6 1.0
N C:ASN880 4.4 105.3 1.0
CA C:VAL879 4.5 95.5 1.0
CB A:GLU881 4.5 101.3 1.0
CB C:ASP877 4.5 113.4 1.0
CG C:GLU883 4.7 106.8 1.0
CB C:ASN880 4.7 99.7 1.0
C C:VAL879 4.8 101.0 1.0
N C:VAL879 4.8 100.1 1.0
O C:ASP877 4.9 111.3 1.0
C C:ASP877 5.0 108.7 1.0
OE2 A:GLU881 5.0 126.9 1.0

Calcium binding site 7 out of 8 in 7dxg

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Calcium binding site 7 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ca1003

b:98.7
occ:1.00
O D:GLU144 2.5 94.3 1.0
OD1 D:ASP890 2.5 121.4 1.0
OE1 D:GLU144 2.7 142.8 1.0
CD D:GLU144 3.6 113.1 1.0
CG D:ASP890 3.7 109.9 1.0
C D:GLU144 3.7 82.2 1.0
OE2 D:GLU144 4.1 113.5 1.0
OD2 D:ASP890 4.3 114.1 1.0
CA D:HIS145 4.3 81.2 1.0
N D:LEU146 4.5 91.2 1.0
N D:HIS145 4.5 78.0 1.0
CB D:GLU144 4.6 83.5 1.0
CA D:ASP890 4.7 83.7 1.0
CG D:GLU144 4.7 97.6 1.0
ND1 D:HIS145 4.7 79.6 1.0
CB D:ASP890 4.8 90.8 1.0
CA D:GLU144 4.8 79.9 1.0
OE1 D:GLU147 4.8 111.5 1.0
NZ B:LYS888 4.8 104.2 1.0
C D:HIS145 5.0 87.4 1.0

Calcium binding site 8 out of 8 in 7dxg

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Calcium binding site 8 out of 8 in the Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of SAR7334-Bound TRPC6 at 2.9 Angstrom within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ca1006

b:127.2
occ:1.00
OE1 D:GLU883 2.5 113.5 1.0
OE1 B:GLU881 2.9 129.6 1.0
OE2 D:GLU883 3.2 125.4 1.0
O D:GLU878 3.2 104.5 1.0
CD D:GLU883 3.2 115.9 1.0
CD B:GLU881 3.8 124.1 1.0
CG B:GLU881 3.8 110.5 1.0
ND2 D:ASN880 3.9 104.6 1.0
CG D:ASN880 4.0 100.7 1.0
OD1 D:ASN880 4.1 103.9 1.0
C D:GLU878 4.2 101.6 1.0
N D:ASN880 4.4 105.3 1.0
CA D:VAL879 4.5 95.5 1.0
CB B:GLU881 4.5 101.3 1.0
CB D:ASP877 4.5 113.4 1.0
CG D:GLU883 4.7 106.8 1.0
CB D:ASN880 4.7 99.7 1.0
C D:VAL879 4.8 101.0 1.0
N D:VAL879 4.8 100.1 1.0
O D:ASP877 4.9 111.3 1.0
C D:ASP877 5.0 108.7 1.0
OE2 B:GLU881 5.0 126.9 1.0

Reference:

W.Guo, Q.Tang, M.Wei, Y.Kang, J.X.Wu, L.Chen. Structural Mechanism of Human TRPC3 and TRPC6 Channel Regulation By Their Intracellular Calcium-Binding Sites. Neuron V. 110 1023 2022.
ISSN: ISSN 0896-6273
PubMed: 35051376
DOI: 10.1016/J.NEURON.2021.12.023
Page generated: Fri Jul 19 00:12:58 2024

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