Calcium in PDB 7piu: Cryo-Em Structure of the Agonist Setmelanotide Bound to the Active Melanocortin-4 Receptor (MC4R) in Complex with the Heterotrimeric Gs Protein at 2.6 A Resolution.

The binding sites of Calcium atom in the Cryo-Em Structure of the Agonist Setmelanotide Bound to the Active Melanocortin-4 Receptor (MC4R) in Complex with the Heterotrimeric Gs Protein at 2.6 A Resolution. (pdb code 7piu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cryo-Em Structure of the Agonist Setmelanotide Bound to the Active Melanocortin-4 Receptor (MC4R) in Complex with the Heterotrimeric Gs Protein at 2.6 A Resolution., PDB code: 7piu:

Calcium binding site 1 out of 1 in the Cryo-Em Structure of the Agonist Setmelanotide Bound to the Active Melanocortin-4 Receptor (MC4R) in Complex with the Heterotrimeric Gs Protein at 2.6 A Resolution.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Agonist Setmelanotide Bound to the Active Melanocortin-4 Receptor (MC4R) in Complex with the Heterotrimeric Gs Protein at 2.6 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca401 b:34.8 occ:1.00 O P:DPN5 2.6 50.1 1.0 OD1 R:ASP126 2.9 57.9 1.0 OE2 R:GLU100 2.9 79.5 0.5 OE2 R:GLU100 3.0 79.5 0.5 OD2 R:ASP126 3.1 58.3 1.0 CG R:ASP126 3.3 57.2 1.0 OD2 R:ASP122 3.3 80.3 1.0 C P:DPN5 3.8 49.6 1.0 CG R:ASP122 4.0 80.1 1.0 OD1 R:ASP122 4.0 80.8 1.0 CD R:GLU100 4.1 80.5 0.5 CD R:GLU100 4.2 80.5 0.5 O P:CYS2 4.2 73.7 1.0 O P:HOH102 4.2 56.4 1.0 N P:DPN5 4.2 51.5 1.0 NH1 P:ARG1 4.4 88.3 1.0 CA P:DPN5 4.5 49.8 1.0 C P:HIS4 4.5 54.6 1.0 OE1 R:GLU100 4.6 81.8 0.5 O R:ASP122 4.7 77.0 1.0 CB P:DPN5 4.7 49.4 1.0 NH1 P:ARG6 4.8 47.8 1.0 CB R:ASP126 4.9 56.0 1.0 CA P:HIS4 4.9 57.5 1.0 OE1 R:GLU100 4.9 81.8 0.5 N P:ARG6 4.9 50.3 1.0 O P:HIS4 4.9 55.0 1.0

N.A.Heyder, G.Kleinau, D.Speck, A.Schmidt, S.Paisdzior, M.Szczepek, B.Bauer, A.Koch, M.Gallandi, D.Kwiatkowski, J.Burger, T.Mielke, A.G.Beck-Sickinger, P.W.Hildebrand, C.M.T.Spahn, D.Hilger, M.Schacherl, H.Biebermann, T.Hilal, P.Kuhnen, B.K.Kobilka, P.Scheerer. Structures of Active Melanocortin-4 Receptor-Gs-Protein Complexes with Ndp-Alpha-Msh and Setmelanotide. Cell Res. V. 31 1176 2021.
ISSN: ISSN 1001-0602
PubMed: 34561620
DOI: 10.1038/S41422-021-00569-8