Calcium in PDB 7pxe: CA2+ Bound Drosophila Slo Channel

The structure of CA2+ Bound Drosophila Slo Channel also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Potassium	(K)	4 atoms

The binding sites of Calcium atom in the CA2+ Bound Drosophila Slo Channel (pdb code 7pxe). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the CA2+ Bound Drosophila Slo Channel, PDB code: 7pxe:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:63.5 occ:1.00 O A:GLN977 2.4 64.1 1.0 OD1 A:ASP983 2.4 77.3 1.0 O A:ASP980 2.4 70.1 1.0 O C:HOH1304 2.4 69.6 1.0 OD1 A:ASP985 2.5 77.3 1.0 OD1 C:ASN463 2.6 59.4 1.0 OD2 A:ASP985 2.6 77.3 1.0 CG A:ASP985 2.9 77.3 1.0 O A:HOH1302 3.2 69.2 1.0 CG A:ASP983 3.3 77.3 1.0 C A:ASP980 3.5 70.1 1.0 C A:GLN977 3.5 64.1 1.0 CG C:ASN463 3.5 59.4 1.0 OD2 A:ASP983 3.6 77.3 1.0 ND2 C:ASN463 3.8 59.4 1.0 O A:ASP983 4.1 77.3 1.0 CA A:GLN977 4.2 64.1 1.0 N A:GLN981 4.3 72.4 1.0 CA A:ASP980 4.3 70.1 1.0 CB A:ASP985 4.4 77.3 1.0 N A:ASP980 4.4 70.1 1.0 CA A:GLN981 4.4 72.4 1.0 CB A:ASP980 4.6 70.1 1.0 N A:PHE978 4.6 61.3 1.0 C A:ASP983 4.7 77.3 1.0 CB A:ASP983 4.7 77.3 1.0 C A:GLN981 4.7 72.4 1.0 CB A:GLN977 4.7 64.1 1.0 O A:GLN981 4.8 72.4 1.0 O A:HOH1324 4.8 66.1 1.0 CA A:PHE978 4.8 61.3 1.0 N A:ASP983 4.9 77.3 1.0 CB C:ASN463 4.9 59.4 1.0 CA A:ASP983 5.0 77.3 1.0

Calcium binding site 2 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1202 b:62.4 occ:1.00 O A:ARG528 2.4 68.5 1.0 O A:GLN616 2.4 67.3 1.0 OE1 A:GLU550 2.5 65.7 1.0 O A:GLY548 2.5 64.2 1.0 OD2 A:ASP381 2.8 73.5 1.0 OE2 A:GLU550 2.9 65.7 1.0 CD A:GLU550 3.0 65.7 1.0 CG A:ASP381 3.4 73.5 1.0 C A:ARG528 3.5 68.5 1.0 C A:GLY548 3.6 64.2 1.0 C A:GLN616 3.6 67.3 1.0 CB A:ASP381 4.1 73.5 1.0 CA A:GLY548 4.1 64.2 1.0 OD1 A:ASP381 4.1 73.5 1.0 CA A:SER529 4.3 76.5 1.0 OH A:TYR552 4.3 67.2 1.0 N A:SER529 4.3 76.5 1.0 N A:ARG528 4.3 68.5 1.0 NE2 A:GLN616 4.3 67.3 1.0 CA A:GLN616 4.4 67.3 1.0 CG A:GLU550 4.5 65.7 1.0 CA A:ARG528 4.5 68.5 1.0 N A:SER617 4.6 71.3 1.0 N A:MET549 4.7 66.3 1.0 CA A:SER617 4.7 71.3 1.0 CB A:SER617 5.0 71.3 1.0 CA A:MET549 5.0 66.3 1.0

Calcium binding site 3 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:64.6 occ:1.00 O B:GLN977 2.4 64.2 1.0 OD1 B:ASP983 2.4 77.2 1.0 O B:ASP980 2.4 70.1 1.0 O B:HOH1306 2.4 69.9 1.0 OD1 B:ASP985 2.5 77.7 1.0 OD1 D:ASN463 2.5 60.4 1.0 OD2 B:ASP985 2.6 77.7 1.0 CG B:ASP985 2.9 77.7 1.0 O B:HOH1302 3.2 68.3 1.0 CG B:ASP983 3.3 77.2 1.0 CG D:ASN463 3.4 60.4 1.0 C B:ASP980 3.5 70.1 1.0 C B:GLN977 3.5 64.2 1.0 OD2 B:ASP983 3.6 77.2 1.0 ND2 D:ASN463 3.7 60.4 1.0 O B:ASP983 4.1 77.2 1.0 CA B:GLN977 4.2 64.2 1.0 N B:GLN981 4.3 72.7 1.0 CA B:ASP980 4.3 70.1 1.0 CB B:ASP985 4.4 77.7 1.0 N B:ASP980 4.4 70.1 1.0 CA B:GLN981 4.4 72.7 1.0 CB B:ASP980 4.6 70.1 1.0 N B:PHE978 4.6 61.3 1.0 C B:ASP983 4.7 77.2 1.0 CB B:ASP983 4.7 77.2 1.0 C B:GLN981 4.7 72.7 1.0 CB B:GLN977 4.7 64.2 1.0 O B:GLN981 4.8 72.7 1.0 O B:HOH1326 4.8 65.9 1.0 CB D:ASN463 4.8 60.4 1.0 O D:ASN463 4.8 60.4 1.0 CA B:PHE978 4.8 61.3 1.0 N B:ASP983 4.9 77.2 1.0 CA B:ASP983 5.0 77.2 1.0

Calcium binding site 4 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1202 b:62.6 occ:1.00 O B:ARG528 2.4 68.2 1.0 O B:GLN616 2.4 67.8 1.0 OE1 B:GLU550 2.5 65.7 1.0 O B:GLY548 2.5 64.4 1.0 OD2 B:ASP381 2.8 74.0 1.0 OE2 B:GLU550 2.9 65.7 1.0 CD B:GLU550 3.0 65.7 1.0 CG B:ASP381 3.4 74.0 1.0 C B:ARG528 3.5 68.2 1.0 C B:GLY548 3.6 64.4 1.0 C B:GLN616 3.6 67.8 1.0 CB B:ASP381 4.1 74.0 1.0 CA B:GLY548 4.1 64.4 1.0 OD1 B:ASP381 4.1 74.0 1.0 CA B:SER529 4.3 77.7 1.0 OH B:TYR552 4.3 66.8 1.0 N B:SER529 4.3 77.7 1.0 N B:ARG528 4.3 68.2 1.0 NE2 B:GLN616 4.3 67.8 1.0 CA B:GLN616 4.4 67.8 1.0 CG B:GLU550 4.5 65.7 1.0 CA B:ARG528 4.5 68.2 1.0 N B:SER617 4.6 71.1 1.0 N B:MET549 4.7 65.9 1.0 CA B:SER617 4.7 71.1 1.0 CB B:SER617 5.0 71.1 1.0 CA B:MET549 5.0 65.9 1.0

Calcium binding site 5 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1201 b:62.3 occ:1.00 O C:GLN977 2.4 64.2 1.0 OD1 C:ASP983 2.4 77.3 1.0 O C:ASP980 2.4 70.5 1.0 O C:HOH1303 2.4 70.0 1.0 OD1 C:ASP985 2.5 76.8 1.0 OD1 B:ASN463 2.5 59.8 1.0 OD2 C:ASP985 2.6 76.8 1.0 CG C:ASP985 2.9 76.8 1.0 O C:HOH1302 3.2 69.3 1.0 CG C:ASP983 3.3 77.3 1.0 CG B:ASN463 3.4 59.8 1.0 C C:ASP980 3.5 70.5 1.0 C C:GLN977 3.5 64.2 1.0 OD2 C:ASP983 3.6 77.3 1.0 ND2 B:ASN463 3.8 59.8 1.0 O C:ASP983 4.1 77.3 1.0 CA C:GLN977 4.1 64.2 1.0 N C:GLN981 4.3 73.0 1.0 CA C:ASP980 4.3 70.5 1.0 CB C:ASP985 4.4 76.8 1.0 N C:ASP980 4.4 70.5 1.0 CA C:GLN981 4.4 73.0 1.0 CB C:ASP980 4.6 70.5 1.0 N C:PHE978 4.6 61.8 1.0 C C:ASP983 4.7 77.3 1.0 CB C:ASP983 4.7 77.3 1.0 C C:GLN981 4.7 73.0 1.0 CB C:GLN977 4.7 64.2 1.0 O C:GLN981 4.8 73.0 1.0 CB B:ASN463 4.8 59.8 1.0 O C:HOH1327 4.8 65.2 1.0 CA C:PHE978 4.8 61.8 1.0 N C:ASP983 4.9 77.3 1.0 CA C:ASP983 5.0 77.3 1.0

Calcium binding site 6 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1202 b:62.9 occ:1.00 O C:ARG528 2.4 68.6 1.0 O C:GLN616 2.4 67.8 1.0 OE1 C:GLU550 2.5 65.9 1.0 O C:GLY548 2.5 64.2 1.0 OD2 C:ASP381 2.8 74.5 1.0 OE2 C:GLU550 2.9 65.9 1.0 CD C:GLU550 3.0 65.9 1.0 CG C:ASP381 3.4 74.5 1.0 C C:ARG528 3.5 68.6 1.0 C C:GLY548 3.6 64.2 1.0 C C:GLN616 3.6 67.8 1.0 CB C:ASP381 4.1 74.5 1.0 CA C:GLY548 4.1 64.2 1.0 OD1 C:ASP381 4.1 74.5 1.0 CA C:SER529 4.3 78.1 1.0 OH C:TYR552 4.3 67.5 1.0 N C:SER529 4.3 78.1 1.0 N C:ARG528 4.3 68.6 1.0 NE2 C:GLN616 4.3 67.8 1.0 CA C:GLN616 4.4 67.8 1.0 CG C:GLU550 4.5 65.9 1.0 CA C:ARG528 4.5 68.6 1.0 N C:SER617 4.6 71.5 1.0 N C:MET549 4.7 65.9 1.0 CA C:SER617 4.7 71.5 1.0 CB C:SER617 5.0 71.5 1.0 CA C:MET549 5.0 65.9 1.0

Calcium binding site 7 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:66.3 occ:1.00 O D:GLN977 2.4 64.3 1.0 OD1 D:ASP983 2.4 78.1 1.0 O D:ASP980 2.4 70.7 1.0 O D:HOH1310 2.4 71.2 1.0 OD1 D:ASP985 2.5 78.7 1.0 OD2 D:ASP985 2.6 78.7 1.0 OD1 A:ASN463 2.7 59.5 1.0 CG D:ASP985 2.9 78.7 1.0 O D:HOH1302 3.2 68.1 1.0 CG D:ASP983 3.3 78.1 1.0 C D:ASP980 3.5 70.7 1.0 C D:GLN977 3.5 64.3 1.0 OD2 D:ASP983 3.6 78.1 1.0 CG A:ASN463 3.7 59.5 1.0 ND2 A:ASN463 3.9 59.5 1.0 O D:ASP983 4.1 78.1 1.0 CA D:GLN977 4.2 64.3 1.0 N D:GLN981 4.3 73.7 1.0 CA D:ASP980 4.3 70.7 1.0 CB D:ASP985 4.4 78.7 1.0 N D:ASP980 4.4 70.7 1.0 CA D:GLN981 4.4 73.7 1.0 CB D:ASP980 4.6 70.7 1.0 N D:PHE978 4.6 61.2 1.0 C D:ASP983 4.7 78.1 1.0 CB D:ASP983 4.7 78.1 1.0 C D:GLN981 4.7 73.7 1.0 CB D:GLN977 4.7 64.3 1.0 O D:HOH1324 4.8 66.3 1.0 O D:GLN981 4.8 73.7 1.0 CA D:PHE978 4.8 61.2 1.0 N D:ASP983 4.9 78.1 1.0 CA D:ASP983 5.0 78.1 1.0

Calcium binding site 8 out of 8 in the CA2+ Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of CA2+ Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1202 b:62.0 occ:1.00 O D:ARG528 2.4 68.8 1.0 O D:GLN616 2.4 67.7 1.0 OE1 D:GLU550 2.5 65.9 1.0 O D:GLY548 2.5 64.8 1.0 OD2 D:ASP381 2.8 74.2 1.0 OE2 D:GLU550 2.9 65.9 1.0 CD D:GLU550 3.0 65.9 1.0 CG D:ASP381 3.4 74.2 1.0 C D:ARG528 3.5 68.8 1.0 C D:GLY548 3.6 64.8 1.0 C D:GLN616 3.6 67.7 1.0 CB D:ASP381 4.1 74.2 1.0 CA D:GLY548 4.1 64.8 1.0 OD1 D:ASP381 4.1 74.2 1.0 CA D:SER529 4.3 77.3 1.0 OH D:TYR552 4.3 67.4 1.0 N D:SER529 4.3 77.3 1.0 N D:ARG528 4.3 68.8 1.0 NE2 D:GLN616 4.3 67.7 1.0 CA D:GLN616 4.4 67.7 1.0 CG D:GLU550 4.5 65.9 1.0 CA D:ARG528 4.5 68.8 1.0 N D:SER617 4.6 71.7 1.0 N D:MET549 4.7 66.3 1.0 CA D:SER617 4.7 71.7 1.0 CB D:SER617 5.0 71.7 1.0 CA D:MET549 5.0 66.3 1.0

T.Raisch, A.Brockmann, U.Ebbinghaus-Kintscher, J.Freigang, O.Gutbrod, J.Kubicek, B.Maertens, O.Hofnagel, S.Raunser. Small Molecule Modulation of the Drosophila Slo Channel Elucidated By Cryo-Em To Be Published.
DOI: 10.1038/S41467-021-27435-W